Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 59010..59625 Replicon plasmid pPsv_PVFi1
Accession NZ_CP078140
Organism Pseudomonas savastanoi pv. savastanoi strain PVFi1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HQ966_RS28785 Protein ID WP_080719041.1
Coordinates 59470..59625 (-) Length 52 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HQ966_RS28780 Protein ID WP_054082441.1
Coordinates 59010..59438 (-) Length 143 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HQ966_RS28740 (HQ966_28530) 54353..54607 - 255 WP_010208566.1 hypothetical protein -
HQ966_RS28745 (HQ966_28535) 54692..54967 + 276 Protein_61 hypothetical protein -
HQ966_RS28750 (HQ966_28540) 54976..55146 + 171 Protein_62 IS630 family transposase -
HQ966_RS28755 (HQ966_28545) 55457..56491 + 1035 WP_015060660.1 IS110-like element ISPsy16 family transposase -
HQ966_RS28760 (HQ966_28550) 56868..57026 + 159 WP_237901257.1 MobA/MobL family protein -
HQ966_RS28765 (HQ966_28555) 57023..57268 - 246 WP_237901249.1 hypothetical protein -
HQ966_RS28775 (HQ966_28565) 58623..58844 - 222 WP_235208930.1 hypothetical protein -
HQ966_RS28780 (HQ966_28570) 59010..59438 - 429 WP_054082441.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HQ966_RS28785 (HQ966_28575) 59470..59625 - 156 WP_080719041.1 type II toxin-antitoxin system HicA family toxin Toxin
HQ966_RS28790 (HQ966_28580) 60113..60586 + 474 WP_074800939.1 DUF3757 domain-containing protein -
HQ966_RS28795 (HQ966_28585) 60840..61139 + 300 WP_160188679.1 FCD domain-containing protein -
HQ966_RS28800 (HQ966_28590) 61174..61962 + 789 WP_002556064.1 amino acid ABC transporter ATP-binding protein -
HQ966_RS28805 (HQ966_28595) 61984..62898 + 915 WP_002556065.1 aminotransferase class IV -
HQ966_RS28810 (HQ966_28600) 62925..63761 + 837 WP_031598553.1 transporter substrate-binding domain-containing protein -
HQ966_RS28815 (HQ966_28605) 63826..64488 + 663 WP_031598554.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..72349 72349


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(11-49)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 52 a.a.        Molecular weight: 5640.61 Da        Isoelectric Point: 10.6276

>T209104 WP_080719041.1 NZ_CP078140:c59625-59470 [Pseudomonas savastanoi pv. savastanoi]
MQPQAALFKAAKGSHFKVYLNGKATIFADHGSKEMHEGLRKSIIKQLGLKD

Download         Length: 156 bp

>T209104 NZ_CP103850:c1930193-1930041 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 143 a.a.        Molecular weight: 15893.28 Da        Isoelectric Point: 5.1798

>AT209104 WP_054082441.1 NZ_CP078140:c59438-59010 [Pseudomonas savastanoi pv. savastanoi]
MYQYQYPLTQHQEQTGVWLSCPNIPEMNASGDTLTEALDEALNGMESALSLYVDQRRKIPQASLPVGDELVMHLPALTVA
KIMLWNSMLDNGVSRAELARRLGCTRQVVDRLVDFLHTSKIEQVERALGLLGRRITLSLEAA

Download         Length: 429 bp

>AT209104 NZ_CP103850:c1930817-1930218 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References