209099

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 5541176..5541787 Replicon chromosome
Accession NZ_CP078139
Organism Pseudomonas savastanoi pv. savastanoi strain PVFi1

Toxin (Protein)


Gene name PfiT Uniprot ID A0A554GDS8
Locus tag HQ966_RS25260 Protein ID WP_002556077.1
Coordinates 5541176..5541526 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID Q4ZME7
Locus tag HQ966_RS25265 Protein ID WP_002556076.1
Coordinates 5541539..5541787 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HQ966_RS25245 (HQ966_25075) 5536376..5537869 + 1494 WP_237772657.1 DUF6531 domain-containing protein -
HQ966_RS25250 (HQ966_25080) 5537866..5540688 + 2823 WP_031598243.1 RHS repeat-associated core domain-containing protein -
HQ966_RS25255 (HQ966_25085) 5540678..5541082 + 405 WP_031598244.1 hypothetical protein -
HQ966_RS25260 (HQ966_25090) 5541176..5541526 - 351 WP_002556077.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HQ966_RS25265 (HQ966_25095) 5541539..5541787 - 249 WP_002556076.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
HQ966_RS25270 (HQ966_25100) 5542125..5543084 + 960 WP_031598247.1 tyrosine-type recombinase/integrase -
HQ966_RS25275 (HQ966_25105) 5543186..5543716 - 531 WP_031598249.1 hypothetical protein -
HQ966_RS25280 (HQ966_25110) 5544041..5544556 - 516 WP_031598251.1 GAF domain-containing protein -
HQ966_RS25285 (HQ966_25115) 5544955..5545395 - 441 WP_044319945.1 hypothetical protein -
HQ966_RS25290 (HQ966_25120) 5545655..5545950 + 296 Protein_4991 integrase core domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-101)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13011.90 Da        Isoelectric Point: 4.4055

>T209099 WP_002556077.1 NZ_CP078139:c5541526-5541176 [Pseudomonas savastanoi pv. savastanoi]
MNTFALRFTDVAQQSLEDQVEHLAVHQGFSSAAQRIDTLIDAIQDKLLSTPLGYPVSPQLSELGVLHYRELNTDGYRIFY
EVMDSDGITFIVILLVLGGKQSVEQALIRYCLLQPI

Download         Length: 351 bp

>T209099 NZ_CP103834:c1570580-1570209 [Actinobacillus genomosp. 1]
ATGTATGAAATAGTCTTTTATCGAGATAAACGAGGGAGAGAACCCGTTAAAGAATTTCTGTTAAGGTTGTTAAAAGAACA
GCAGGAAGGCAGTCGAGAACGATTACACAAAATTAGCCATCATTTAAGCATTTTACATTTGCACGGCACTCGTGCCGGCG
AGAATTATATCAAGCATTTGGAAGATCGTATTTGGCAGCTACGTCCGGTCGGTGATTGTCTGTTATTTGCAAGTATCATT
CGAGGTAAATTCGTATTATTGCATTATTTTGCCAAAAATAATTATCGAATTCCGAAACGGGAGATAGAACGTGCAAAAGT
TCGTTTAGCAGATCTACAGGAGAGAATAAAAGATGAGCCCTATTGGTTCTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9366.73 Da        Isoelectric Point: 9.9579

>AT209099 WP_002556076.1 NZ_CP078139:c5541787-5541539 [Pseudomonas savastanoi pv. savastanoi]
MRVETISFLKRNAADLPLDEPLVVTQNGVPAYVVESYADRKRRDESIALVKLLAISSREYSQGKHCSTDELKARLSRRFT
QK

Download         Length: 249 bp

>AT209099 NZ_CP103834:c1570228-1569935 [Actinobacillus genomosp. 1]
ATGAGCCCTATTGGTTCTAGTTGGACATCGTTTGAACAAGAAATTTTTGACGAGTTGGAAATAGCCGAAACACAATTTCG
CATACGGCTTATTTTAGAGATTATTGAAACCCGTCAGCAACTGGGGATCTCACAAAGAAAGCTGGAAAAATTAAGCGGTG
TGAAACAATCCATGATTGCGCGAGTAGAAAAAGGTTCGGTTAATCCGTCTTTGGCGACTGTATTGAAATTACTCGTTCCG
TTAGGTAAGACTTTACAAATCGTACCGCTGGATAAGCCTAAAGTACCACGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A554GDS8

Antitoxin

Source ID Structure
AlphaFold DB A0A0P9GM89

References