Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 4193220..4193689 Replicon chromosome
Accession NZ_CP078139
Organism Pseudomonas savastanoi pv. savastanoi strain PVFi1

Toxin (Protein)


Gene name relE Uniprot ID Q48BA0
Locus tag HQ966_RS19075 Protein ID WP_002556029.1
Coordinates 4193220..4193501 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q48BA1
Locus tag HQ966_RS19080 Protein ID WP_002556028.1
Coordinates 4193501..4193689 (-) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HQ966_RS19055 (HQ966_18930) 4188332..4189846 + 1515 WP_054082386.1 IS21 family transposase -
HQ966_RS19060 (HQ966_18935) 4189867..4190622 + 756 WP_002552598.1 IS21-like element ISPsy14 family helper ATPase IstB -
HQ966_RS19065 (HQ966_18940) 4190726..4191043 - 318 Protein_3771 transposase zinc-binding domain-containing protein -
HQ966_RS19070 (HQ966_18945) 4191439..4192920 + 1482 WP_002556030.1 XopAG/AvrGf1 family type III secretion system effector -
HQ966_RS19075 (HQ966_18950) 4193220..4193501 - 282 WP_002556029.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HQ966_RS19080 (HQ966_18955) 4193501..4193689 - 189 WP_002556028.1 hypothetical protein Antitoxin
HQ966_RS19085 (HQ966_18960) 4193866..4194457 - 592 Protein_3775 recombinase family protein -
HQ966_RS19090 (HQ966_18965) 4194498..4194917 - 420 WP_044424067.1 type II toxin-antitoxin system VapC family toxin -
HQ966_RS19095 (HQ966_18970) 4194914..4195171 - 258 WP_003381346.1 Arc family DNA-binding protein -
HQ966_RS19100 (HQ966_18975) 4195694..4197193 + 1500 WP_122302115.1 IS21-like element ISPsy20 family transposase -
HQ966_RS19105 (HQ966_18980) 4197186..4197989 + 804 WP_031598096.1 IS21-like element ISPsy20 family helper ATPase IstB -
HQ966_RS19110 (HQ966_18985) 4198145..4198273 - 129 Protein_3780 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10675.35 Da        Isoelectric Point: 8.4392

>T209097 WP_002556029.1 NZ_CP078139:c4193501-4193220 [Pseudomonas savastanoi pv. savastanoi]
MLPVVWLSPALDDLREIATYIAWENPSAARRLKSLLQEAIEPVAEHPYLYRSGRAPGTRELVAHPNYVLVYRVTLKRIEV
VNVIHARQEYPSP

Download         Length: 282 bp

>T209097 NZ_CP103834:1476025-1476276 [Actinobacillus genomosp. 1]
ATGCAAGCAATAACCTACACAGAAGCACGCCAAAATCTAGCCGGTACAATGTCAAAAGTAGCAGAAGATTTTGAGCCTAT
TTTAATTACGAGAAGCAAGGGCGGAAATTGCGTACTTATGTCATATGAGCAGTATTGTTCACTTGAAGAAACCGCCTATT
TAATGCGTTCACCTACCAATGCAAAACGGCTATTGGATAGTGTGGCGGAATTAAGACAGGGACAAGGCATTGAAAGAGAT
TTAATCGAATGA

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 7043.86 Da        Isoelectric Point: 4.2550

>AT209097 WP_002556028.1 NZ_CP078139:c4193689-4193501 [Pseudomonas savastanoi pv. savastanoi]
MANLSPIVSEFETDEQAASYDRWFRAKVAASLADPRPAIPHDEVMAEIEALIDQVETQREKR

Download         Length: 189 bp

>AT209097 NZ_CP103834:1476273-1476533 [Actinobacillus genomosp. 1]
ATGAAACTAACTTTCTCGTCTAATGCGTGGGAAGATTATTTATACTGGCAAAAAACCGATTCAATAATTTTGAAACGTAT
AAACAGCCTGATCAAAGATATTCAACGCCAACCATTCGAAGGCATAGGAAAACCGGAGCCGTTAAAATTCAATCTTTCGG
GCTTTTGGTCAAGGCGAATCAATGAAGAACACCGCTTAATTTACAGCGTGGAAGATGAAGCAATTTTAATAGTAGCATGT
AGATACCATTATGATCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M9HVA1

Antitoxin

Source ID Structure
AlphaFold DB A0A2G9KWB9

References