Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 199380..200053 Replicon chromosome
Accession NZ_CP078139
Organism Pseudomonas savastanoi pv. savastanoi strain PVFi1

Toxin (Protein)


Gene name vapC Uniprot ID H1ZWW2
Locus tag HQ966_RS00950 Protein ID WP_002556053.1
Coordinates 199634..200053 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q48B52
Locus tag HQ966_RS00945 Protein ID WP_003381346.1
Coordinates 199380..199637 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HQ966_RS00930 (HQ966_00910) 194742..196118 + 1377 WP_002556044.1 MATE family efflux transporter -
HQ966_RS00935 (HQ966_00915) 196199..197386 + 1188 WP_031598440.1 indoleacetate--lysine synthetase -
HQ966_RS00940 (HQ966_00920) 197874..199082 + 1209 WP_237901160.1 IS91 family transposase -
HQ966_RS00945 (HQ966_00925) 199380..199637 + 258 WP_003381346.1 Arc family DNA-binding protein Antitoxin
HQ966_RS00950 (HQ966_00930) 199634..200053 + 420 WP_002556053.1 type II toxin-antitoxin system VapC family toxin Toxin
HQ966_RS00955 (HQ966_00935) 200094..200732 + 639 WP_031597920.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 147514..218187 70673
- flank IS/Tn - - 197853..199082 1229


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Arc-like DNA binding domain

(5-46)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15168.46 Da        Isoelectric Point: 4.7010

>T209096 WP_002556053.1 NZ_CP078139:199634-200053 [Pseudomonas savastanoi pv. savastanoi]
MILLDTNVISEPQRREPNAHVLDWIDAQALETLYLSTITVAELRAGIALMPVGKRQDSLRENLEKHLLPMFANRVLSFDM
TCTKAYAELLAKSRAAGLAVETADAFIAAIALANGFTVATRDTGPFEAAGLNVINPWET

Download         Length: 420 bp

>T209096 NZ_CP103833:c2224312-2223941 [Actinobacillus arthritidis]
ATGTATGAAATAGTCTTTTATCGAGATAAACGGGGGCGAGAGCCTGTCAAAGAGTCACTATTGGGACTGCTAAAACAATC
GCACAACGATAACCGTGAAAAATTGCAAAAAATCAGTCATCATTTAAGCATCTTACATTTACACGGTACACGAGCCGGCG
AAAATTATATAAAACATTTGGAAGACCGCATTTGGCAGATTCGTCCAATGAGTGATTGTTTATTACTTACTAGTATTATC
AGAGGGCAATTTGTCTTATTGCACTATTTAGCAAAATCCCATTATCGTATCCCTAAACGGGAAATCGAACGAGCAAAAAG
CAGATTAGCAGACTTACAAGCGAGGATAAAAGATGAGCCCTATTGGTTCTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9401.62 Da        Isoelectric Point: 9.0330

>AT209096 WP_003381346.1 NZ_CP078139:199380-199637 [Pseudomonas savastanoi pv. savastanoi]
VANVNVRNLPDEVHRAIRIQAALHGRSTEAEIRDILERAARPEGRVKLGSFLASIAREVGGLTDKEHTLFENTRITSPAR
AVSFE

Download         Length: 258 bp

>AT209096 NZ_CP103833:c2223960-2223676 [Actinobacillus arthritidis]
ATGAGCCCTATTGGTTCTAGTTGGCATTCATTTGAACAACAAGTGTTGAATCCTTTAGACATTGAAGAACAAAATTTCCG
CATAAAACTTATTCTTGAAATTATAGAAACCCGTCAAGCACTCGGTATTTCTCAACGCAAGTTAGAAAGTTTAAGCGGCG
TAAAGCAATCAATGATTGCCCGAGTAGAAAAAGGCTCGTCCAATCCTTCTTTGGCAACACTATTAAAATTACTGGTTCCG
CTAGGTAAAACGCTACAAATCGTACCGCTGAATGCAGATAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3M2ZA27

Antitoxin

Source ID Structure
AlphaFold DB Q48B52

References