Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 160613..161286 Replicon chromosome
Accession NZ_CP078139
Organism Pseudomonas savastanoi pv. savastanoi strain PVFi1

Toxin (Protein)


Gene name vapC Uniprot ID H1ZWW2
Locus tag HQ966_RS00790 Protein ID WP_002556053.1
Coordinates 160867..161286 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q48B52
Locus tag HQ966_RS00785 Protein ID WP_003381346.1
Coordinates 160613..160870 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HQ966_RS00755 (HQ966_00740) 156205..156948 - 744 WP_237901163.1 IS21-like element ISPsy4 family helper ATPase IstB -
HQ966_RS00760 (HQ966_00745) 156945..157967 - 1023 WP_031598602.1 IS21-like element ISPsy4 family transposase -
HQ966_RS00765 (HQ966_00750) 158563..159192 + 630 WP_031598601.1 ParA family partition ATPase -
HQ966_RS00770 (HQ966_00755) 159189..159419 + 231 WP_019742104.1 hypothetical protein -
HQ966_RS00775 (HQ966_00760) 159473..159982 - 510 WP_031598600.1 GNAT family N-acetyltransferase -
HQ966_RS00780 (HQ966_00765) 159979..160260 - 282 WP_019742102.1 DUF1778 domain-containing protein -
HQ966_RS00785 (HQ966_00770) 160613..160870 + 258 WP_003381346.1 Arc family DNA-binding protein Antitoxin
HQ966_RS00790 (HQ966_00775) 160867..161286 + 420 WP_002556053.1 type II toxin-antitoxin system VapC family toxin Toxin
HQ966_RS00795 (HQ966_00780) 161327..161965 + 639 WP_031597920.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 147514..218187 70673
- inside IScluster/Tn - - 128542..157946 29404


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Arc-like DNA binding domain

(5-46)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15168.46 Da        Isoelectric Point: 4.7010

>T209095 WP_002556053.1 NZ_CP078139:160867-161286 [Pseudomonas savastanoi pv. savastanoi]
MILLDTNVISEPQRREPNAHVLDWIDAQALETLYLSTITVAELRAGIALMPVGKRQDSLRENLEKHLLPMFANRVLSFDM
TCTKAYAELLAKSRAAGLAVETADAFIAAIALANGFTVATRDTGPFEAAGLNVINPWET

Download         Length: 420 bp

>T209095 NZ_CP103833:c2011972-2011505 [Actinobacillus arthritidis]
ATGCATGCACCGGAGTCGCTTTCCGAGCAACATATTGTGCGACATTTTCAATGCGGTGAGGTCGTGCTAGACCAATGGCT
ACAACGTACTGCATTGAAAAATCAGCAAAATAATGCCAGTAAAACCTTTGTTGTGTGTGATGATAATAAACAGGTGATGG
GATTTTATTGTTTATCTGCCGGTTCGGTGAGTCGTCAGTTTGTTGCAGGTGCATTAAGACGTAATATGCCCGATCCGATT
CCTGTGATTATTTTAGGTAGATTAGCTGTCGATTGTTCGGCACAAGGTAAGCAGTTAGGCGTATCAATGTTAAAAGATGC
GGTCTTAAAATCGAAGACGGTAGCGAACCAAATCGGGGTAAAAGCATTGCTTGTTCATGCGTTAAACCCGCAAGCAAAAC
AATTTTATTTAAAGTATGGTTTTTCATGTTCACCCATTGATGAGATGGTTTTAATGTTAAAACTCTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9401.62 Da        Isoelectric Point: 9.0330

>AT209095 WP_003381346.1 NZ_CP078139:160613-160870 [Pseudomonas savastanoi pv. savastanoi]
VANVNVRNLPDEVHRAIRIQAALHGRSTEAEIRDILERAARPEGRVKLGSFLASIAREVGGLTDKEHTLFENTRITSPAR
AVSFE

Download         Length: 258 bp

>AT209095 NZ_CP103833:c2012106-2011975 [Actinobacillus arthritidis]
GTGATTTTAGATCGTACTGTTTTCCAATTAAATGAGCAGACTTTCGAGCAATTTAACCGATTGTTAGAGCAACCGACAAC
GGATAATCCGGGGTTAGATAAACTGTTAAATACCAAAGCGGTGTGGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3M2ZA27

Antitoxin

Source ID Structure
AlphaFold DB Q48B52

References