Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-StbC |
Location | 160613..161286 | Replicon | chromosome |
Accession | NZ_CP078139 | ||
Organism | Pseudomonas savastanoi pv. savastanoi strain PVFi1 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | H1ZWW2 |
Locus tag | HQ966_RS00790 | Protein ID | WP_002556053.1 |
Coordinates | 160867..161286 (+) | Length | 140 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | Q48B52 |
Locus tag | HQ966_RS00785 | Protein ID | WP_003381346.1 |
Coordinates | 160613..160870 (+) | Length | 86 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HQ966_RS00755 (HQ966_00740) | 156205..156948 | - | 744 | WP_237901163.1 | IS21-like element ISPsy4 family helper ATPase IstB | - |
HQ966_RS00760 (HQ966_00745) | 156945..157967 | - | 1023 | WP_031598602.1 | IS21-like element ISPsy4 family transposase | - |
HQ966_RS00765 (HQ966_00750) | 158563..159192 | + | 630 | WP_031598601.1 | ParA family partition ATPase | - |
HQ966_RS00770 (HQ966_00755) | 159189..159419 | + | 231 | WP_019742104.1 | hypothetical protein | - |
HQ966_RS00775 (HQ966_00760) | 159473..159982 | - | 510 | WP_031598600.1 | GNAT family N-acetyltransferase | - |
HQ966_RS00780 (HQ966_00765) | 159979..160260 | - | 282 | WP_019742102.1 | DUF1778 domain-containing protein | - |
HQ966_RS00785 (HQ966_00770) | 160613..160870 | + | 258 | WP_003381346.1 | Arc family DNA-binding protein | Antitoxin |
HQ966_RS00790 (HQ966_00775) | 160867..161286 | + | 420 | WP_002556053.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
HQ966_RS00795 (HQ966_00780) | 161327..161965 | + | 639 | WP_031597920.1 | recombinase family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 147514..218187 | 70673 | |
- | inside | IScluster/Tn | - | - | 128542..157946 | 29404 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 140 a.a. Molecular weight: 15168.46 Da Isoelectric Point: 4.7010
>T209095 WP_002556053.1 NZ_CP078139:160867-161286 [Pseudomonas savastanoi pv. savastanoi]
MILLDTNVISEPQRREPNAHVLDWIDAQALETLYLSTITVAELRAGIALMPVGKRQDSLRENLEKHLLPMFANRVLSFDM
TCTKAYAELLAKSRAAGLAVETADAFIAAIALANGFTVATRDTGPFEAAGLNVINPWET
MILLDTNVISEPQRREPNAHVLDWIDAQALETLYLSTITVAELRAGIALMPVGKRQDSLRENLEKHLLPMFANRVLSFDM
TCTKAYAELLAKSRAAGLAVETADAFIAAIALANGFTVATRDTGPFEAAGLNVINPWET
Download Length: 420 bp
>T209095 NZ_CP103833:c2011972-2011505 [Actinobacillus arthritidis]
ATGCATGCACCGGAGTCGCTTTCCGAGCAACATATTGTGCGACATTTTCAATGCGGTGAGGTCGTGCTAGACCAATGGCT
ACAACGTACTGCATTGAAAAATCAGCAAAATAATGCCAGTAAAACCTTTGTTGTGTGTGATGATAATAAACAGGTGATGG
GATTTTATTGTTTATCTGCCGGTTCGGTGAGTCGTCAGTTTGTTGCAGGTGCATTAAGACGTAATATGCCCGATCCGATT
CCTGTGATTATTTTAGGTAGATTAGCTGTCGATTGTTCGGCACAAGGTAAGCAGTTAGGCGTATCAATGTTAAAAGATGC
GGTCTTAAAATCGAAGACGGTAGCGAACCAAATCGGGGTAAAAGCATTGCTTGTTCATGCGTTAAACCCGCAAGCAAAAC
AATTTTATTTAAAGTATGGTTTTTCATGTTCACCCATTGATGAGATGGTTTTAATGTTAAAACTCTAA
ATGCATGCACCGGAGTCGCTTTCCGAGCAACATATTGTGCGACATTTTCAATGCGGTGAGGTCGTGCTAGACCAATGGCT
ACAACGTACTGCATTGAAAAATCAGCAAAATAATGCCAGTAAAACCTTTGTTGTGTGTGATGATAATAAACAGGTGATGG
GATTTTATTGTTTATCTGCCGGTTCGGTGAGTCGTCAGTTTGTTGCAGGTGCATTAAGACGTAATATGCCCGATCCGATT
CCTGTGATTATTTTAGGTAGATTAGCTGTCGATTGTTCGGCACAAGGTAAGCAGTTAGGCGTATCAATGTTAAAAGATGC
GGTCTTAAAATCGAAGACGGTAGCGAACCAAATCGGGGTAAAAGCATTGCTTGTTCATGCGTTAAACCCGCAAGCAAAAC
AATTTTATTTAAAGTATGGTTTTTCATGTTCACCCATTGATGAGATGGTTTTAATGTTAAAACTCTAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9401.62 Da Isoelectric Point: 9.0330
>AT209095 WP_003381346.1 NZ_CP078139:160613-160870 [Pseudomonas savastanoi pv. savastanoi]
VANVNVRNLPDEVHRAIRIQAALHGRSTEAEIRDILERAARPEGRVKLGSFLASIAREVGGLTDKEHTLFENTRITSPAR
AVSFE
VANVNVRNLPDEVHRAIRIQAALHGRSTEAEIRDILERAARPEGRVKLGSFLASIAREVGGLTDKEHTLFENTRITSPAR
AVSFE
Download Length: 258 bp
>AT209095 NZ_CP103833:c2012106-2011975 [Actinobacillus arthritidis]
GTGATTTTAGATCGTACTGTTTTCCAATTAAATGAGCAGACTTTCGAGCAATTTAACCGATTGTTAGAGCAACCGACAAC
GGATAATCCGGGGTTAGATAAACTGTTAAATACCAAAGCGGTGTGGGAGTAA
GTGATTTTAGATCGTACTGTTTTCCAATTAAATGAGCAGACTTTCGAGCAATTTAACCGATTGTTAGAGCAACCGACAAC
GGATAATCCGGGGTTAGATAAACTGTTAAATACCAAAGCGGTGTGGGAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3M2ZA27 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | Q48B52 |