Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4469327..4469913 Replicon chromosome
Accession NZ_CP078137
Organism Escherichia coli strain Sx181-0-1

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag KW063_RS22180 Protein ID WP_042014162.1
Coordinates 4469327..4469557 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag KW063_RS22185 Protein ID WP_000593555.1
Coordinates 4469554..4469913 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KW063_RS22170 (4465364) 4465364..4468099 + 2736 WP_000149165.1 ribosome-associated ATPase/putative transporter RbbA -
KW063_RS22175 (4468099) 4468099..4469223 + 1125 WP_001216257.1 ABC transporter permease -
KW063_RS22180 (4469327) 4469327..4469557 + 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
KW063_RS22185 (4469554) 4469554..4469913 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KW063_RS22190 (4470033) 4470033..4470434 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
KW063_RS22195 (4470440) 4470440..4471246 - 807 WP_000173666.1 nickel import ATP-binding protein NikE -
KW063_RS22200 (4471243) 4471243..4472007 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
KW063_RS22205 (4472007) 4472007..4472840 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
KW063_RS22210 (4472837) 4472837..4473781 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T209093 WP_042014162.1 NZ_CP078137:4469327-4469557 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

>T209093 NZ_CP103833:82561-82983 [Actinobacillus arthritidis]
ATGTATTTATTAGATACCAATATTGTTTCCGAACTACGTAAGATGGAAAGCGGAAAAGTCGATGCTAATGTGGTGAAATG
GTTTCAACAAGTCAATTTAACCGATGCTTATTTAAGTGTTATCACTCTCTTTGAAATTAAGTTAGGTATTTTGCAACTTA
AACGCAAAGATATTCAACAAGCTAAACTTTTACAAAGTTGGTTTGAACAAAAACTCCTGCCTAATTTTGAAAATAGAATT
TTACCGCTTGATACGAAAGTTATGATGACTTGTGCAGAGTTTCATATTCCGGATAAAAAGCCCTTAAATGATTCTTATAT
AGCCGCTACGGCTAAAGCACATAGATTTAAAATTGTGACGAGAAATGTGAAAGATTTTAAAGGATGTGGGGTAGAGGTAC
TGAATCCATTTATTGAGTATTAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT209093 WP_000593555.1 NZ_CP078137:4469554-4469913 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT209093 NZ_CP103833:82274-82561 [Actinobacillus arthritidis]
ATGGCAGTAATTAGTTCCAAAGAATTTAACCAACGTGCCAGTGCGGTATTAAAAATTGCTGAAACCGAGCCGGTGTATAT
TACTAAATGGGGCAAGGTGGTTAGTGTGTTGGCAAGTTATGCTCATTATCAAGCTCAAACGAAATCACAAAGTTTAGCGG
AGGCTTTTAGCAGTACGGCATCAACAGCAACATTAAGTGAGGAAGCGGAACAGCAATTTGAGCAAACTTTGCAACAAGTA
CGCCAACAAATCAAAATAAGAGTACCGGATTTATCGGAGTGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References