Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ypjF-yeeU/CbtA-CbeA
Location 583809..584543 Replicon chromosome
Accession NZ_CP078137
Organism Escherichia coli strain Sx181-0-1

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag KW063_RS03565 Protein ID WP_135566204.1
Coordinates 583809..584138 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag KW063_RS03570 Protein ID WP_135566205.1
Coordinates 584178..584543 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KW063_RS23665 (579617) 579617..579775 + 159 Protein_544 recombinase family protein -
KW063_RS03555 (579999) 579999..580118 + 120 WP_000927517.1 hypothetical protein -
KW063_RS03560 (580183) 580183..583443 + 3261 Protein_546 AIDA repeat-containing protein -
KW063_RS03565 (583809) 583809..584138 - 330 WP_135566204.1 TA system toxin CbtA family protein Toxin
KW063_RS03570 (584178) 584178..584543 - 366 WP_135566205.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KW063_RS03575 (584569) 584569..584790 - 222 WP_135566206.1 DUF987 domain-containing protein -
KW063_RS03580 (584787) 584787..585329 - 543 WP_135566207.1 DNA repair protein RadC -
KW063_RS03585 (585342) 585342..585785 - 444 WP_135566208.1 antirestriction protein -
KW063_RS03590 (585816) 585816..586637 - 822 WP_135566223.1 DUF932 domain-containing protein -
KW063_RS03595 (586736) 586736..586966 - 231 Protein_553 DUF905 domain-containing protein -
KW063_RS03600 (587038) 587038..587487 - 450 WP_135566209.1 IrmA family protein -
KW063_RS03605 (587484) 587484..587936 - 453 WP_117076902.1 hypothetical protein -
KW063_RS03610 (587973) 587973..588542 - 570 WP_135566224.1 hypothetical protein -
KW063_RS03615 (588542) 588542..589246 - 705 WP_135566210.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(17-117)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12450.12 Da        Isoelectric Point: 9.5066

>T209075 WP_135566204.1 NZ_CP078137:c584138-583809 [Escherichia coli]
MQTLSSHPTRATHPYLSPIETWQRLLTHLLSQHYGLTLNDTPFSNETTIREHIDAGVSLSDAVNFLVEKYGLVRIDRKGF
SWQEQTPYLSVADILRARRSTGLLKTNVK

Download         Length: 330 bp

>T209075 NZ_CP103826:c1247908-1246586 [Actinobacillus equuli subsp. haemolyticus]
ATGGTGAAGCGTTTATGTGTGTTAATGAATGGGGAATTAGTTGGTTTTTTTGAGCGTACTATGTCCGGTTCGCATTTATT
CCGTTATGCAGATGAGTGGTTTTTATCTCCAAATGTTAGACCTATTTCTCTTTCTATGCCATTAAGAAGGGAGGTTTATC
AAGGTAAAGAAGTAATTAATTTTTTTGATAACTTATTACCTGATCACCCTCAAGTTAGAGCTAGAATTGCTGCGCGATTT
CAAGCTGAAACACAACAACCTTTTGAATTGTTAGCTAAGATTGGACGAGATGCAACCGGAGCAATAACCCTATTAGAAGA
AAACACAGAAATTCCCAATCATAAAGTTATTCATGCAACGGAATTAAACGAAAATGAACTTCATTCGTTATTATTAGGCT
ATCAGCAAAATGCACCACTTGGCATGTTGGATGAAGCACAAGATTTTCGAATTTCTATCGCAGGGGCTCAAGAAAAGACA
GCATTATTATGGTATAACGAACGTTGGCAATTACCCCATGGATTAACCCCAACGACACATATTATTAAATTACCGATAGG
TAAAATACAAACACCTAAATATCAATTAGATCTGTCTCAAAGTGTAGACAACGAATTAATTTGTTTACGCTTATGTGCTG
CCTTCGGTTTACCGACTGCAAATGTAAATTTATTAGAGGTCGGGGATGTGCGAGCATTGGTTGTAGAACGGTTTGATCGT
AAATTACATTCTTCAAATAAATATTTTTTACGCTTACCTTATGAAGATTTTTGCCAAGTATTCGGCTTAGCGCCAACCCA
AAAATATGAGAGTGATGGTGGTATCGGTATTCGACACATTATGGATAAACTTTTGTATTCCAGTCATACTTCGGATCGTG
CACAATTCATGAAAACCCAATTTTTATTTTGGGTGCTTGGAGCAATAGATGGGCATGCCAAAAACTTTTCTATTGCATTG
AAGTCGCAGAGTCGTTATCACTTATCGCCAATTTATGATGTTATATCGGCTTATCCAATGCCGGGAGGTAAAGGGTGGCA
TCAGAGTGATTTGCAACTTGCGATGAGTCTGTGTAGTACCCAAAAAGGTAAGAAATGGAGTTGGCAAAAAATACGACCGG
TACATTATCTGTCTACCGCTAAATCTGTCGGATTTAATCAGTTAGAAATGAAACATATTATTGAAGAGATTTCAGATACG
GCATTAAAAAAGTTAGATTTTGTAGCTGATAGGCTGCCAATAAATATTAATGAACAAGTAAGAGATCAAATTTTTAATGG
AGTCAAAAAACAGATTGATAAAATCAAATTAGATAGGATTTAA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13532.34 Da        Isoelectric Point: 5.5280

>AT209075 WP_135566205.1 NZ_CP078137:c584543-584178 [Escherichia coli]
MNNHSESGTKLENPACQQWGLKRAMTPCFGARLVQEGNRLHYLADRAGFSGALTDDFSMRLDQAFPLMMKQLELMLTSGE
LSPRNQHCVTLYHNGLTCEADTLGSCGYVYIVVYPDQTEPQ

Download         Length: 366 bp

>AT209075 NZ_CP103826:c1248144-1247902 [Actinobacillus equuli subsp. haemolyticus]
ATGCTAATCAATGATCCTAATAGTTTAGCCGTTTACCTACGTGATATTCGTAAGCAGCAGAAACAATCACAAAAAATGAT
TGCTCAACGAGTCGGTTTGCGACAAGCAACGATTTCTACATTCGAGACCCGACCTGATAAAGTCACAATAGAAACGCTAT
TTAAAATAGTTCATTCTCTTGGTTTAGAAATTCATTTAGAAGAAAAGCATACGAATATGTTTAATAGGAGCGATGAATGG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References