Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 115176..115711 Replicon plasmid unnamed1
Accession NZ_CP078136
Organism Escherichia coli strain Sx181-0-1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KW063_RS00620 Protein ID WP_087905911.1
Coordinates 115176..115463 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KW063_RS00625 Protein ID WP_187187660.1
Coordinates 115460..115711 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KW063_RS00590 (110335) 110335..110463 + 129 Protein_118 serine/threonine protein kinase -
KW063_RS00595 (110584) 110584..111324 + 741 WP_087905906.1 tyrosine-type recombinase/integrase -
KW063_RS00600 (111609) 111609..112586 - 978 WP_034173277.1 RepB family plasmid replication initiator protein -
KW063_RS00605 (113184) 113184..114235 - 1052 Protein_121 IS3 family transposase -
KW063_RS23655 (114200) 114200..114510 + 311 Protein_122 hypothetical protein -
KW063_RS00610 (114599) 114599..114817 - 219 WP_232796006.1 hypothetical protein -
KW063_RS00615 (114902) 114902..115162 - 261 WP_089633444.1 hypothetical protein -
KW063_RS00620 (115176) 115176..115463 - 288 WP_087905911.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KW063_RS00625 (115460) 115460..115711 - 252 WP_187187660.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KW063_RS00630 (115969) 115969..116181 - 213 WP_087905913.1 hypothetical protein -
KW063_RS00635 (116284) 116284..116649 - 366 WP_218335115.1 transposase -
KW063_RS00640 (116828) 116828..117138 - 311 Protein_129 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - paa / faeC / faeD / faeE / faeF / faeH / faeI / faeJ / cofA / faeC 1..136082 136082
- inside IScluster/Tn - - 113469..117013 3544


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11268.33 Da        Isoelectric Point: 10.3926

>T209071 WP_087905911.1 NZ_CP078136:c115463-115176 [Escherichia coli]
MRYQVKFREDALKEWQKLDKVIQQQFAKKLKKCCDNPYIPSAKLRGIKDCYKIKLRASGFRLVYQVIDEQLIIAVVAVGK
RERSDVYNLASERMR

Download         Length: 288 bp

>T209071 NZ_CP103825:c1208910-1208566 [Actinobacillus equuli subsp. haemolyticus]
ATGAATTCTGATGAATATTTAACCTTTGTTGAGGTCGGTACATTCGAGGAAGATCGTAAGCAATTAATGGCAGACGATGA
GTACCAATTATTCCAAGCATATTTATTAGAGCATTACGAATTAGGGGATTTTATTCCCCATACAGGTGGTTGCCAAAAGA
TCAGGTGGCGCTTACCGGAAAATAATAAGGGGAAAAGTGCTGGTGTTCGAATTATCTATTATGTTAGAAGTTTAACAGGG
CGAATTTACCTAATTACTATGTATGGAAAAAGCGAAAAAGTTAATCTAAATGCTCGAGAAAAAGCGATTATGAAGAAAAT
TATTTCGAGATTAATAGGAGAGTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9177.53 Da        Isoelectric Point: 4.4702

>AT209071 WP_187187660.1 NZ_CP078136:c115711-115460 [Escherichia coli]
MPNIILSDTSASVSELKKNPMATVSAGDGFPVAILNRNQPAFYCVPAELYEKMLDALDDQELVKLVAKRSNQPLHDVDLD
KYL

Download         Length: 252 bp

>AT209071 NZ_CP103825:c1208561-1208265 [Actinobacillus equuli subsp. haemolyticus]
ATGGAAAAACGTTTATTTGAGCGCCTTGTACAAGGATTAGAAGAAATGGTTGCTATTGAAAAAGGTGAGGTGGAAGTACC
ATCGCATCGCATCCATGTACATAAAATTCCAAATACTAAGGCGATTCGTACACAACACCATTTGAAACAGGCAGAATTTG
CACAGCTGTTAGGTGTCAGTACCAATTTGGTGCAATCTTGGGAAATCGGCAGACGAGTCCCTAATGGAGCGGCAAGAAAA
TTATTGGCGATTATCGAACAACAACCGAATTTAGTCCCTTTGCTACAATCTCTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References