Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 39118..39893 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP078136 | ||
| Organism | Escherichia coli strain Sx181-0-1 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | A0A6D0V6Q2 |
| Locus tag | KW063_RS00235 | Protein ID | WP_000405252.1 |
| Coordinates | 39411..39893 (+) | Length | 161 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | - |
| Locus tag | KW063_RS00230 | Protein ID | WP_001346256.1 |
| Coordinates | 39118..39420 (+) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KW063_RS00195 (34223) | 34223..34969 | + | 747 | WP_218335158.1 | conjugal transfer pilus acetylase TraX | - |
| KW063_RS00200 (35028) | 35028..35888 | + | 861 | WP_097493262.1 | alpha/beta hydrolase | - |
| KW063_RS00205 (35991) | 35991..36551 | + | 561 | WP_097433445.1 | fertility inhibition protein FinO | - |
| KW063_RS00210 (36681) | 36681..36893 | + | 213 | WP_096152115.1 | hypothetical protein | - |
| KW063_RS00215 (37138) | 37138..37227 | + | 90 | Protein_43 | endonuclease | - |
| - (37468) | 37468..37527 | - | 60 | NuclAT_0 | - | - |
| - (37468) | 37468..37527 | - | 60 | NuclAT_0 | - | - |
| - (37468) | 37468..37527 | - | 60 | NuclAT_0 | - | - |
| - (37468) | 37468..37527 | - | 60 | NuclAT_0 | - | - |
| KW063_RS00225 (37813) | 37813..38850 | + | 1038 | WP_218335160.1 | IS630-like element ISEc40 family transposase | - |
| KW063_RS00230 (39118) | 39118..39420 | + | 303 | WP_001346256.1 | DUF1778 domain-containing protein | Antitoxin |
| KW063_RS00235 (39411) | 39411..39893 | + | 483 | WP_000405252.1 | GNAT family N-acetyltransferase | Toxin |
| KW063_RS00240 (40196) | 40196..40450 | + | 255 | WP_000083846.1 | replication regulatory protein RepA | - |
| KW063_RS00245 (40557) | 40557..40754 | + | 198 | WP_218335163.1 | protein CopA/IncA | - |
| KW063_RS00250 (40732) | 40732..41394 | + | 663 | Protein_49 | plasmid replication initiator RepA | - |
| KW063_RS00255 (42403) | 42403..43161 | - | 759 | WP_087905389.1 | substrate-binding domain-containing protein | - |
| KW063_RS00260 (43454) | 43454..43944 | + | 491 | Protein_51 | ATP-binding protein | - |
| KW063_RS00265 (44152) | 44152..44418 | - | 267 | Protein_52 | IS66 family insertion sequence element accessory protein TnpB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | paa / faeC / faeD / faeE / faeF / faeH / faeI / faeJ / cofA / faeC | 1..136082 | 136082 | |
| - | inside | IScluster/Tn | - | paa | 37813..46226 | 8413 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 161 a.a. Molecular weight: 17687.47 Da Isoelectric Point: 7.1036
>T209070 WP_000405252.1 NZ_CP078136:39411-39893 [Escherichia coli]
MEINVTAPVLLTDEHILQPFDCGNEVLSNWLHGRAMKNQMLNASRTFVICLEGTLRVVGYYSLATGSVTHAELGRSLRHN
MPNPVPVVLLGRLAVDVCTQGHGFGKWLLSDAIHRVVNLADQVGIKAVMVHAIDDDARAFYERFGFVQSVVAPNTLFYKV
MEINVTAPVLLTDEHILQPFDCGNEVLSNWLHGRAMKNQMLNASRTFVICLEGTLRVVGYYSLATGSVTHAELGRSLRHN
MPNPVPVVLLGRLAVDVCTQGHGFGKWLLSDAIHRVVNLADQVGIKAVMVHAIDDDARAFYERFGFVQSVVAPNTLFYKV
Download Length: 483 bp
>T209070 NZ_CP103824:c1651434-1651045 [Actinobacillus equuli subsp. haemolyticus]
ATGTATATGCTAGATACTAATACGGTGAGTTATTTCTTTAGGCAAGAGCCTACTGTGGTTAAGAAACTACAACAACTTAA
TCCAGAATTGATTTGTATTTCATCGGTCACGGCTGCAGAGTTGTTTTATGGTGTAAAAAAACGTAATAGTCAGAAACTTA
CTTCATTTTTAAATACTTTTTTATCCGCAATTACGGTTATGGATTGGGATTATCAAGTGGCGGAAGTGTATGGTCAGTTG
CGAGCAGAGATGGAACGAGAAGGCAAAATCATGGGCGTTCAAGATCAAATGATTGGAGCTCATGCCCTAGCAACAGAATG
TGTTCTTGTTTCCAGCGATAAAGCCTTTCAATTTATCCCTAATCTCGTATTAGAAAATTGGTGGAAGTAA
ATGTATATGCTAGATACTAATACGGTGAGTTATTTCTTTAGGCAAGAGCCTACTGTGGTTAAGAAACTACAACAACTTAA
TCCAGAATTGATTTGTATTTCATCGGTCACGGCTGCAGAGTTGTTTTATGGTGTAAAAAAACGTAATAGTCAGAAACTTA
CTTCATTTTTAAATACTTTTTTATCCGCAATTACGGTTATGGATTGGGATTATCAAGTGGCGGAAGTGTATGGTCAGTTG
CGAGCAGAGATGGAACGAGAAGGCAAAATCATGGGCGTTCAAGATCAAATGATTGGAGCTCATGCCCTAGCAACAGAATG
TGTTCTTGTTTCCAGCGATAAAGCCTTTCAATTTATCCCTAATCTCGTATTAGAAAATTGGTGGAAGTAA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11602.19 Da Isoelectric Point: 4.4569
>AT209070 WP_001346256.1 NZ_CP078136:39118-39420 [Escherichia coli]
MEVVMPTTASIRKTPRENQINIRATDEERAVIDYAASLVNKNRTDFIIELAYQEAKNIILDQRLFVLDDECYDSFITQLE
APVQNAEGRERLMAVKPEWK
MEVVMPTTASIRKTPRENQINIRATDEERAVIDYAASLVNKNRTDFIIELAYQEAKNIILDQRLFVLDDECYDSFITQLE
APVQNAEGRERLMAVKPEWK
Download Length: 303 bp
>AT209070 NZ_CP103824:c1651695-1651435 [Actinobacillus equuli subsp. haemolyticus]
ATGGAAAAGGTCGCACGTTTATTTAGAAACGGACGTAATCAAGCCGTACGATTACCTGTTGAATTTGAGTTTAATGCGAA
GCAAGTTTATGTGTTTAAAGAAGCAAACGGCGATATTACGCTTTCGATACGTTCTCGCAATCAGCAAAATTGGCAGAAAG
TCTTTGAGTTATTACCAATGCTTGAATGTGATGAACAGTTTTTATCGGAAAAAGAACGCAAGCAAGAAATGGCAACTCGT
GATCCCTTTGAGGGCTTTTAG
ATGGAAAAGGTCGCACGTTTATTTAGAAACGGACGTAATCAAGCCGTACGATTACCTGTTGAATTTGAGTTTAATGCGAA
GCAAGTTTATGTGTTTAAAGAAGCAAACGGCGATATTACGCTTTCGATACGTTCTCGCAATCAGCAAAATTGGCAGAAAG
TCTTTGAGTTATTACCAATGCTTGAATGTGATGAACAGTTTTTATCGGAAAAAGAACGCAAGCAAGAAATGGCAACTCGT
GATCCCTTTGAGGGCTTTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|