Detailed information of TA system TA209037

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 3634907..3635817
• Replicon: chromosome
• Accession: NZ_CP078120
• Organism: Halomonas sp. 18071143

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: KVY02_RS17020
• Protein ID: WP_218314002.1
• Coordinates: 3635353..3635817 (+)
• Length: 155 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A2M9TCY0
• Locus tag: KVY02_RS17015
• Protein ID: WP_016915365.1
• Coordinates: 3634907..3635356 (+)
• Length: 150 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KVY02_RS16990	3630112..3630414	-	303	WP_016915359.1	urease subunit gamma	-
KVY02_RS16995	3630448..3631332	-	885	WP_218314000.1	urease accessory protein UreD	-
KVY02_RS17000	3631660..3632286	-	627	WP_081135930.1	SCO family protein	-
KVY02_RS17005	3632286..3632813	-	528	WP_016915363.1	copper chaperone PCu(A)C	-
KVY02_RS17010	3633333..3634694	-	1362	WP_218314001.1	diguanylate cyclase	-
KVY02_RS17015	3634907..3635356	+	450	WP_016915365.1	DUF2384 domain-containing protein	Antitoxin
KVY02_RS17020	3635353..3635817	+	465	WP_218314002.1	RES family NAD+ phosphorylase	Toxin
KVY02_RS17025	3635834..3636541	-	708	WP_218314003.1	urea ABC transporter ATP-binding subunit UrtE	-
KVY02_RS17030	3636541..3637377	-	837	WP_016915368.1	urea ABC transporter ATP-binding protein UrtD	-
KVY02_RS17035	3637374..3638516	-	1143	WP_016915369.1	urea ABC transporter permease subunit UrtC	-
KVY02_RS17040	3638523..3640130	-	1608	WP_081193398.1	urea ABC transporter permease subunit UrtB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (6-149)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (31-90)

Sequences

Toxin

Protein

• Length: 155 a.a.
• Molecular weight: 16950.21 Da
• Isoelectric Point: 4.4322

>T209037 WP_218314002.1 NZ_CP078120:3635353-3635817 [Halomonas sp. 18071143]
MSEVTAYRLVKRKFQESAFDGEGARLYGGRWNSPGNACVYVASSESLALLEIMVHLESYRLLNAYALLRLTLPNQSILSI
GEEDLPENWREAPAPAETADLGDGWLASGQSLALALPSVVVPRELNYMLNPAHPLFEHAVASAEELPFQPDPRL

Nucleotide

• Length: 465 bp

>T209037 NZ_CP103809:c1820580-1820218 [Actinobacillus genomosp. 1]
GTGAAGTTAGTTTTTGTAGAATTACCACCTTTTGAGCGATATAGACAAAAGCACCTTAGTGATGAAGAATATAAACATTT
TCAGAATGAGCTATTAGAAAATCCTAATAAAGGAGATTTAATCCAAGGTACGAACGGCTTACGCAAAATTAGAATTGCAG
ATATGCAACGAAATAAAGGTAAGAGAGGTGGAGCAAGGGTAATTTATTATCATATTGTGAATTATTCAAAAATTTTGTTG
GTTACTGCATATGGTAAAGATGAACAATCAGATTTATCTAATACGGAACGCAATATGTTAGCGAATAAAGTGAAGCGTAT
TGTTGAATTAGAGATAAGGAGTTGTAATGGGAAAACTTTTTGA

Antitoxin

Protein

• Length: 150 a.a.
• Molecular weight: 16584.02 Da
• Isoelectric Point: 10.2591

>AT209037 WP_016915365.1 NZ_CP078120:3634907-3635356 [Halomonas sp. 18071143]
MTATFSQYQPTKAVASGYWQQIGLPARGRKLHELLHEGVEYRVYPRLAKVSGIEQKALARYVDIPSATLSRRAKSGRFKM
AESDRLYRFAELFKAALDLFEGDAEGARAWLLKPNAGLGGRRPVEMSATSAEYQTVLNLIGRLEHGVSV

Nucleotide

• Length: 450 bp

>AT209037 NZ_CP103809:c1820234-1819926 [Actinobacillus genomosp. 1]
ATGGGAAAACTTTTTGATGATTTAATGGAAGGGCTTGATGCTTATGAAAAACATATCCAAGGCAAAATCACCCTGCGAAC
CACGGTATTAGAAAAGCCTGAACCAGTAGAACTTAGCCCGTCTGAAGTTAAATCGATTCGAGAAAAATTAAATCTGTCGC
AAGCGGTTTTTGCGCATAAATTGCATACTTCCGTGCGGACTTATCAAGGGTGGGAGCAAGGCAAAACTAAACCGAATCCA
CAAGCTACTTTGTTATTACGAATGGTGGACAAATCTCCGCAATTATTAGAACAAATGGCACAGCTCTAA

Structures

Antitoxin

• AlphaFold DB: A0A2M9TCY0