Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3540204..3541763 Replicon chromosome
Accession NZ_CP078120
Organism Halomonas sp. 18071143

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag KVY02_RS16595 Protein ID WP_218313962.1
Coordinates 3540204..3541511 (-) Length 436 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag KVY02_RS16600 Protein ID WP_218313963.1
Coordinates 3541515..3541763 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KVY02_RS16575 3535594..3536352 + 759 WP_198517603.1 5-oxoprolinase subunit PxpA -
KVY02_RS16580 3536349..3537053 + 705 WP_016915291.1 5-oxoprolinase subunit PxpB -
KVY02_RS16585 3537050..3537994 + 945 WP_218313960.1 biotin-dependent carboxyltransferase family protein -
KVY02_RS16590 3538013..3540034 - 2022 WP_218313961.1 PhoX family phosphatase -
KVY02_RS16595 3540204..3541511 - 1308 WP_218313962.1 type II toxin-antitoxin system HipA family toxin Toxin
KVY02_RS16600 3541515..3541763 - 249 WP_218313963.1 helix-turn-helix domain-containing protein Antitoxin
KVY02_RS16605 3542024..3544177 - 2154 WP_218313964.1 catalase/peroxidase HPI -
KVY02_RS16610 3544514..3545959 - 1446 WP_039174945.1 NAD(P)(+) transhydrogenase (Re/Si-specific) subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-64)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 48653.85 Da        Isoelectric Point: 7.2726

>T209036 WP_218313962.1 NZ_CP078120:c3541511-3540204 [Halomonas sp. 18071143]
VANLTVALNGIEVGRLSLGRSGAMAFRYLPEWLNRPGARAISLSMPLSSASYRGAVVYNFFDNLLPDSEAIRARMQAKFQ
LATGHPFDLLAAVGRDCIGAIQLYPETDTIPNVRQITAEPLDETDIATLLSGYQELPLGMHRDGDFRISLAGAQEKMALL
WHRECWHRPSFATPTSHIFKLPIGFLSHSNIDLRDSNENEWLCLKILEAFGVPVANAELARFEQHTVLVVARFDRRWSSD
GSWLMRLPQEDFCQALGIAPALKYENDGGPGIRAGMELLMGSQQATSDRENFFKAQIMFWLLAAIDGHAKNFSVFIEPQT
AYRMTPLYDVISAYPLMAKGSLPEAKARMAMSLKGKNRHYHWSRFLPRHFLSTAQQVGFSRRRTLEIIQSILAQADAAMS
RVAALLPDDFPDTVSASIMEGLGRQLKRLEKDIDQ

Download         Length: 1308 bp

>T209036 NZ_CP103809:c1532826-1532455 [Actinobacillus genomosp. 1]
ATGTATGAAATAGTCTTTTATCGAGATAAACGAGGGAGAGAACCCGTTAAAGAATTTCTGTTAAGGTTGTTAAAAGAACA
GCAGGAAGGCAGTCGAGAACGATTACACAAAATTAGCCATCATTTAAGCATTTTACATTTGCATGGTACTCGTGCCGGCG
AGAATTATATCAAGCATTTGGAAGATCGTATTTGGCAGCTACGTCCGGTCGGTGATTGTCTGTTATTTGCAAGTATCATT
CGAGGTAAATTCGTATTACTGCATTATTTTGCCAAAAATAATTATCGAATTCCGAAACGGGAGATAGAACGTGCAAAAGT
TCGTTTAGCAGATCTACAGGAGAGAATAAAAGATGAGCCCTATTGGTTCTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9270.58 Da        Isoelectric Point: 7.2052

>AT209036 WP_218313963.1 NZ_CP078120:c3541763-3541515 [Halomonas sp. 18071143]
MKITSPDMLAKALKEARSHNGMSQKDAAEQVGIKQATVSAFENRPEKSRVETLFKLMAALGLELHVAKRESKQSEQVWDE
EW

Download         Length: 249 bp

>AT209036 NZ_CP103809:c1532474-1532181 [Actinobacillus genomosp. 1]
ATGAGCCCTATTGGTTCTAGTTGGACATCGTTTGAACAAGAAATTTTTGACGAGTTGGAAATAGCCGAAACACAATTTCG
CATACGGCTTATTTTAGAGATTATTGAAACCCGTCAGCAACTGGGGATCTCACAAAGAAAGCTGGAAAAATTAAGCGGTG
TGAAACAATCCATGATTGCGCGAGTAGAAAAAGGTTCGGTTAATCCGTCTTTGGCGACCGTATTGAAATTACTCGTTCCG
TTAGGTAAGACTTTACAAATCGTACCACTGGATAAGCCTAAAGTACCACGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References