Detailed information of TA system TA209036

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 3540204..3541763
• Replicon: chromosome
• Accession: NZ_CP078120
• Organism: Halomonas sp. 18071143

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: KVY02_RS16595
• Protein ID: WP_218313962.1
• Coordinates: 3540204..3541511 (-)
• Length: 436 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: KVY02_RS16600
• Protein ID: WP_218313963.1
• Coordinates: 3541515..3541763 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KVY02_RS16575	3535594..3536352	+	759	WP_198517603.1	5-oxoprolinase subunit PxpA	-
KVY02_RS16580	3536349..3537053	+	705	WP_016915291.1	5-oxoprolinase subunit PxpB	-
KVY02_RS16585	3537050..3537994	+	945	WP_218313960.1	biotin-dependent carboxyltransferase family protein	-
KVY02_RS16590	3538013..3540034	-	2022	WP_218313961.1	PhoX family phosphatase	-
KVY02_RS16595	3540204..3541511	-	1308	WP_218313962.1	type II toxin-antitoxin system HipA family toxin	Toxin
KVY02_RS16600	3541515..3541763	-	249	WP_218313963.1	helix-turn-helix domain-containing protein	Antitoxin
KVY02_RS16605	3542024..3544177	-	2154	WP_218313964.1	catalase/peroxidase HPI	-
KVY02_RS16610	3544514..3545959	-	1446	WP_039174945.1	NAD(P)(+) transhydrogenase (Re/Si-specific) subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (10-64)

Sequences

Toxin

Protein

• Length: 436 a.a.
• Molecular weight: 48653.85 Da
• Isoelectric Point: 7.2726

>T209036 WP_218313962.1 NZ_CP078120:c3541511-3540204 [Halomonas sp. 18071143]
VANLTVALNGIEVGRLSLGRSGAMAFRYLPEWLNRPGARAISLSMPLSSASYRGAVVYNFFDNLLPDSEAIRARMQAKFQ
LATGHPFDLLAAVGRDCIGAIQLYPETDTIPNVRQITAEPLDETDIATLLSGYQELPLGMHRDGDFRISLAGAQEKMALL
WHRECWHRPSFATPTSHIFKLPIGFLSHSNIDLRDSNENEWLCLKILEAFGVPVANAELARFEQHTVLVVARFDRRWSSD
GSWLMRLPQEDFCQALGIAPALKYENDGGPGIRAGMELLMGSQQATSDRENFFKAQIMFWLLAAIDGHAKNFSVFIEPQT
AYRMTPLYDVISAYPLMAKGSLPEAKARMAMSLKGKNRHYHWSRFLPRHFLSTAQQVGFSRRRTLEIIQSILAQADAAMS
RVAALLPDDFPDTVSASIMEGLGRQLKRLEKDIDQ

Nucleotide

• Length: 1308 bp

>T209036 NZ_CP103809:c1532826-1532455 [Actinobacillus genomosp. 1]
ATGTATGAAATAGTCTTTTATCGAGATAAACGAGGGAGAGAACCCGTTAAAGAATTTCTGTTAAGGTTGTTAAAAGAACA
GCAGGAAGGCAGTCGAGAACGATTACACAAAATTAGCCATCATTTAAGCATTTTACATTTGCATGGTACTCGTGCCGGCG
AGAATTATATCAAGCATTTGGAAGATCGTATTTGGCAGCTACGTCCGGTCGGTGATTGTCTGTTATTTGCAAGTATCATT
CGAGGTAAATTCGTATTACTGCATTATTTTGCCAAAAATAATTATCGAATTCCGAAACGGGAGATAGAACGTGCAAAAGT
TCGTTTAGCAGATCTACAGGAGAGAATAAAAGATGAGCCCTATTGGTTCTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9270.58 Da
• Isoelectric Point: 7.2052

>AT209036 WP_218313963.1 NZ_CP078120:c3541763-3541515 [Halomonas sp. 18071143]
MKITSPDMLAKALKEARSHNGMSQKDAAEQVGIKQATVSAFENRPEKSRVETLFKLMAALGLELHVAKRESKQSEQVWDE
EW

Nucleotide

• Length: 249 bp

>AT209036 NZ_CP103809:c1532474-1532181 [Actinobacillus genomosp. 1]
ATGAGCCCTATTGGTTCTAGTTGGACATCGTTTGAACAAGAAATTTTTGACGAGTTGGAAATAGCCGAAACACAATTTCG
CATACGGCTTATTTTAGAGATTATTGAAACCCGTCAGCAACTGGGGATCTCACAAAGAAAGCTGGAAAAATTAAGCGGTG
TGAAACAATCCATGATTGCGCGAGTAGAAAAAGGTTCGGTTAATCCGTCTTTGGCGACCGTATTGAAATTACTCGTTCCG
TTAGGTAAGACTTTACAAATCGTACCACTGGATAAGCCTAAAGTACCACGTTAA