Detailed information of TA system TA209035

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3424551..3425161
• Replicon: chromosome
• Accession: NZ_CP078120
• Organism: Halomonas sp. 18071143

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: KVY02_RS16075
• Protein ID: WP_081138750.1
• Coordinates: 3424979..3425161 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: KVY02_RS16070
• Protein ID: WP_081138748.1
• Coordinates: 3424551..3424955 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KVY02_RS16065	3421564..3424260	-	2697	WP_081194829.1	CRISPR-associated helicase/endonuclease Cas3	-
KVY02_RS16070	3424551..3424955	-	405	WP_081138748.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
KVY02_RS16075	3424979..3425161	-	183	WP_081138750.1	type II toxin-antitoxin system HicA family toxin	Toxin
KVY02_RS16080	3426892..3428148	-	1257	WP_081138507.1	ISL3 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3405696..3437122	31426

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6749.89 Da
• Isoelectric Point: 10.7304

>T209035 WP_081138750.1 NZ_CP078120:c3425161-3424979 [Halomonas sp. 18071143]
VKSKDVIKEMEADGWYLDRVSGSHHVFKHPTKLGSVPVPHPKKDLPKGTIHNIRKLAGLR

Nucleotide

• Length: 183 bp

>T209035 NZ_CP103809:1444022-1444282 [Actinobacillus genomosp. 1]
ATGAAACTAACTTTCTCGTCTAATGCGTGGGAAGATTATTTATACTGGCAAAAAACCGATAAAATAATTTTGAAACGTAT
AAACAGCCTGATCAAAGATATTCAACGCCAACCATTCGAAGGCATAGGAAAACCGGAGCCGTTAAAATTCAATCTTTCGG
GCTTTTGGTCAAGGCGAATCAATGAAGAACACCGCTTAATTTACACCGTGGAAGATGAAGCAATTTTAATAGTAGCGTGT
AGATACCATTATGATCAGTAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14725.58 Da
• Isoelectric Point: 4.6366

>AT209035 WP_081138748.1 NZ_CP078120:c3424955-3424551 [Halomonas sp. 18071143]
MQYPVAIEWGDEHTATGIVIPDIPGAVTAGDTTEHAYEMAVEVAHIQLEELANENKDIPMPRSIAEHRQNPEFEGCGWGI
IDIDITPYLGKTEKVNVTLPGHVIRQIDQYVTTHGIKSRSAFIASAALEKLNHA

Nucleotide

• Length: 405 bp

>AT209035 NZ_CP103809:1443774-1444025 [Actinobacillus genomosp. 1]
ATGCAAGCAATAACCTACACAGAAGCACGCCAAAATCTAGCCGGTACAATGTCAAAAGTAGCAGAAGATTTTGAGCCTAT
TTTAATTACGAGAAGCAAGGGCGGAAATTGCGTACTTATGTCATATGAGCAGTATTGTTCACTTGAAGAAACAGCCTATT
TAATGCGTTCACCTACCAATGCAAAACGGCTATTGGATAGTGTGGCGGAATTAAGACAGGGACAAGGCATTGAAAGAGAT
TTAATCGAATGA