Detailed information of TA system TA209034

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /BrnT(toxin)
• Location: 3083647..3084169
• Replicon: chromosome
• Accession: NZ_CP078120
• Organism: Halomonas sp. 18071143

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A2M9TBV7
• Locus tag: KVY02_RS14475
• Protein ID: WP_058578261.1
• Coordinates: 3083906..3084169 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: KVY02_RS14470
• Protein ID: WP_058578262.1
• Coordinates: 3083647..3083916 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KVY02_RS14450	3080037..3080651	+	615	WP_218313782.1	DNA-3-methyladenine glycosylase	-
KVY02_RS14455	3080648..3081514	-	867	WP_218313783.1	NAD-dependent protein deacetylase	-
KVY02_RS14460	3081611..3082783	+	1173	WP_218313784.1	UbiH/UbiF/VisC/COQ6 family ubiquinone biosynthesis hydroxylase	-
KVY02_RS18370	3082861..3083133	+	273	WP_232710857.1	hypothetical protein	-
KVY02_RS18375	3083168..3083614	+	447	WP_256357502.1	hypothetical protein	-
KVY02_RS14470	3083647..3083916	-	270	WP_058578262.1	hypothetical protein	Antitoxin
KVY02_RS14475	3083906..3084169	-	264	WP_058578261.1	BrnT family toxin	Toxin
KVY02_RS14480	3084245..3084780	-	536	Protein_2824	amino acid racemase	-
KVY02_RS14485	3084870..3085331	-	462	WP_256357503.1	hypothetical protein	-
KVY02_RS14490	3085509..3086162	-	654	WP_081195307.1	DsbA family oxidoreductase	-
KVY02_RS14495	3086226..3087167	-	942	WP_218313785.1	cation transporter	-
KVY02_RS14500	3087238..3087795	-	558	Protein_2828	PAS domain-containing protein	-
KVY02_RS14505	3087974..3088945	-	972	WP_218313787.1	ribonuclease Z	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (6-81)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10314.77 Da
• Isoelectric Point: 7.2035

>T209034 WP_058578261.1 NZ_CP078120:c3084169-3083906 [Halomonas sp. 18071143]
MNEFEFDVNKSQANLTKHGIDFEAAQALWKDPYLLEIRAKSEGEPRFLLIGMISEKHWSAVVTYREERIRLISVRRSRKK
EVDIYES

Nucleotide

• Length: 264 bp

>T209034 NZ_CP103809:1443774-1444025 [Actinobacillus genomosp. 1]
ATGCAAGCAATAACCTACACAGAAGCACGCCAAAATCTAGCCGGTACAATGTCAAAAGTAGCAGAAGATTTTGAGCCTAT
TTTAATTACGAGAAGCAAGGGCGGAAATTGCGTACTTATGTCATATGAGCAGTATTGTTCACTTGAAGAAACAGCCTATT
TAATGCGTTCACCTACCAATGCAAAACGGCTATTGGATAGTGTGGCGGAATTAAGACAGGGACAAGGCATTGAAAGAGAT
TTAATCGAATGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10253.48 Da
• Isoelectric Point: 6.4848

>AT209034 WP_058578262.1 NZ_CP078120:c3083916-3083647 [Halomonas sp. 18071143]
MKAKEFDKKFDENQDDVLDDLDFSTARRVNQEQKRINVDFPAWVVESLDREAARMGVTRQSIIKVWLVERLQAEAAHKPH
GHNSVGGPH

Nucleotide

• Length: 270 bp

>AT209034 NZ_CP103809:1444022-1444282 [Actinobacillus genomosp. 1]
ATGAAACTAACTTTCTCGTCTAATGCGTGGGAAGATTATTTATACTGGCAAAAAACCGATAAAATAATTTTGAAACGTAT
AAACAGCCTGATCAAAGATATTCAACGCCAACCATTCGAAGGCATAGGAAAACCGGAGCCGTTAAAATTCAATCTTTCGG
GCTTTTGGTCAAGGCGAATCAATGAAGAACACCGCTTAATTTACACCGTGGAAGATGAAGCAATTTTAATAGTAGCGTGT
AGATACCATTATGATCAGTAA

Structures

Toxin

• AlphaFold DB: A0A2M9TBV7