Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | DhiAT/- |
| Location | 2819803..2820587 | Replicon | chromosome |
| Accession | NZ_CP078120 | ||
| Organism | Halomonas sp. 18071143 | ||
Toxin (Protein)
| Gene name | dhiT | Uniprot ID | - |
| Locus tag | KVY02_RS13245 | Protein ID | WP_081139058.1 |
| Coordinates | 2820318..2820587 (-) | Length | 90 a.a. |
Antitoxin (Protein)
| Gene name | dhiA | Uniprot ID | A0A2M9TC71 |
| Locus tag | KVY02_RS13240 | Protein ID | WP_016914639.1 |
| Coordinates | 2819803..2820324 (-) | Length | 174 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KVY02_RS13205 | 2815618..2816202 | + | 585 | WP_218313660.1 | manganese efflux pump MntP family protein | - |
| KVY02_RS13210 | 2816274..2817155 | - | 882 | WP_218313661.1 | class A beta-lactamase | - |
| KVY02_RS13215 | 2817211..2817663 | - | 453 | WP_218313662.1 | N-acetyltransferase | - |
| KVY02_RS13220 | 2817695..2818117 | - | 423 | WP_218313663.1 | GFA family protein | - |
| KVY02_RS13225 | 2818156..2818626 | - | 471 | WP_039176635.1 | GNAT family N-acetyltransferase | - |
| KVY02_RS13230 | 2818650..2819177 | - | 528 | WP_218313664.1 | N-acetyltransferase | - |
| KVY02_RS13235 | 2819281..2819739 | - | 459 | WP_218313665.1 | OsmC family protein | - |
| KVY02_RS13240 | 2819803..2820324 | - | 522 | WP_016914639.1 | DUF2442 domain-containing protein | Antitoxin |
| KVY02_RS13245 | 2820318..2820587 | - | 270 | WP_081139058.1 | DUF4160 domain-containing protein | Toxin |
| KVY02_RS13250 | 2820754..2821575 | + | 822 | WP_218313666.1 | aldo/keto reductase | - |
| KVY02_RS13255 | 2821739..2821990 | + | 252 | WP_039176654.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | - |
| KVY02_RS13260 | 2821987..2822241 | + | 255 | WP_218313667.1 | Txe/YoeB family addiction module toxin | - |
| KVY02_RS13265 | 2822461..2822916 | - | 456 | WP_218313668.1 | lysophospholipase | - |
| KVY02_RS13270 | 2823023..2823304 | - | 282 | WP_218313669.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| KVY02_RS13275 | 2823301..2823573 | - | 273 | WP_016914646.1 | ribbon-helix-helix protein, CopG family | - |
| KVY02_RS13280 | 2823759..2824232 | - | 474 | WP_218313670.1 | GNAT family N-acetyltransferase | - |
| KVY02_RS13285 | 2824339..2824680 | - | 342 | WP_218315091.1 | GFA family protein | - |
| KVY02_RS13290 | 2824821..2825141 | - | 321 | WP_218313671.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10312.91 Da Isoelectric Point: 6.7439
>T209032 WP_081139058.1 NZ_CP078120:c2820587-2820318 [Halomonas sp. 18071143]
MPEIDALLGLSFCLYFFDNKQHKLPHLHVKYGSYELIIAIETGECLEGYLPNKQRKRAESHIFDHREQLMVMWHKAVNGE
NPGKLGDVC
MPEIDALLGLSFCLYFFDNKQHKLPHLHVKYGSYELIIAIETGECLEGYLPNKQRKRAESHIFDHREQLMVMWHKAVNGE
NPGKLGDVC
Download Length: 270 bp
>T209032 NZ_CP103808:2011262-2011660 [Actinobacillus genomosp. 1]
ATGCTGACTTATATGCTTGATACTAACATTGCGATTTATGTCATTAAACGCAGACCACTTGAAGTGCTGGATAAGTTTAA
TTTAAATTCCACCCGTCTTTGTGTAAGTAGTATCACTGCAGCGGAGCTGTATTATGGGGCAGAGAAAAGCCAGTTTCCGG
AACAGAATATGGCAGTAATTGAGGATTTTCTTTCTCGTTTAACGATTCTTGATTATACGCATAAGGAGGCTACTCACTTT
GGCAATATCAAAGCACATTTATCTAAGCACGGTAAGATTATCGGGGAGAACGATATTCACATTGCCGCACATGCAAGAAG
TGAAGGACTTGTATTAGTAACCAATAACTTGCGTGAATTTGAACGTGTGGAAGGATTACGATTAGCTAATTGGGTATAG
ATGCTGACTTATATGCTTGATACTAACATTGCGATTTATGTCATTAAACGCAGACCACTTGAAGTGCTGGATAAGTTTAA
TTTAAATTCCACCCGTCTTTGTGTAAGTAGTATCACTGCAGCGGAGCTGTATTATGGGGCAGAGAAAAGCCAGTTTCCGG
AACAGAATATGGCAGTAATTGAGGATTTTCTTTCTCGTTTAACGATTCTTGATTATACGCATAAGGAGGCTACTCACTTT
GGCAATATCAAAGCACATTTATCTAAGCACGGTAAGATTATCGGGGAGAACGATATTCACATTGCCGCACATGCAAGAAG
TGAAGGACTTGTATTAGTAACCAATAACTTGCGTGAATTTGAACGTGTGGAAGGATTACGATTAGCTAATTGGGTATAG
Antitoxin
Download Length: 174 a.a. Molecular weight: 19071.62 Da Isoelectric Point: 6.7334
>AT209032 WP_016914639.1 NZ_CP078120:c2820324-2819803 [Halomonas sp. 18071143]
MLKIVDVDVISGHALALTFSDGYFGRADLTAYFSKPPFSEIKDFKRFSLTPEGSLNWSGNELSAATLRAITKGEQKSADV
FVNVQEMEAVIKQASWESMKEGRADILQAAIRSYVEQFGHSQVIAKAGIKSRTSAYRSLKPETRPNFDTLVQLGHAVIEL
AQERAVSINESSI
MLKIVDVDVISGHALALTFSDGYFGRADLTAYFSKPPFSEIKDFKRFSLTPEGSLNWSGNELSAATLRAITKGEQKSADV
FVNVQEMEAVIKQASWESMKEGRADILQAAIRSYVEQFGHSQVIAKAGIKSRTSAYRSLKPETRPNFDTLVQLGHAVIEL
AQERAVSINESSI
Download Length: 522 bp
>AT209032 NZ_CP103808:2011032-2011262 [Actinobacillus genomosp. 1]
ATGGAAGCATCGGTATTTATGACAAACCGTAGTCAAGCGGTACGATTGCCGGCAGAAGTACGCTTTGCAAGTGATGTAAA
AAAACTTTCTGTAAGAGTAGTCGGTAATGAGCGTATTTTGGCTCCGATTAACCAAAGTTGGGATAGCTTCTTTCTGGGGG
CGGCAACGGTAAGCGATGATTTTATGACAGAGCGTGAAATCAGCATTCAGCCCGAACGTGAGGGACTGTAA
ATGGAAGCATCGGTATTTATGACAAACCGTAGTCAAGCGGTACGATTGCCGGCAGAAGTACGCTTTGCAAGTGATGTAAA
AAAACTTTCTGTAAGAGTAGTCGGTAATGAGCGTATTTTGGCTCCGATTAACCAAAGTTGGGATAGCTTCTTTCTGGGGG
CGGCAACGGTAAGCGATGATTTTATGACAGAGCGTGAAATCAGCATTCAGCCCGAACGTGAGGGACTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|