Detailed information of TA system TA209032

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DhiAT/-
• Location: 2819803..2820587
• Replicon: chromosome
• Accession: NZ_CP078120
• Organism: Halomonas sp. 18071143

Toxin (Protein)

• Gene name: dhiT
• Uniprot ID: -
• Locus tag: KVY02_RS13245
• Protein ID: WP_081139058.1
• Coordinates: 2820318..2820587 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: dhiA
• Uniprot ID: A0A2M9TC71
• Locus tag: KVY02_RS13240
• Protein ID: WP_016914639.1
• Coordinates: 2819803..2820324 (-)
• Length: 174 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KVY02_RS13205	2815618..2816202	+	585	WP_218313660.1	manganese efflux pump MntP family protein	-
KVY02_RS13210	2816274..2817155	-	882	WP_218313661.1	class A beta-lactamase	-
KVY02_RS13215	2817211..2817663	-	453	WP_218313662.1	N-acetyltransferase	-
KVY02_RS13220	2817695..2818117	-	423	WP_218313663.1	GFA family protein	-
KVY02_RS13225	2818156..2818626	-	471	WP_039176635.1	GNAT family N-acetyltransferase	-
KVY02_RS13230	2818650..2819177	-	528	WP_218313664.1	N-acetyltransferase	-
KVY02_RS13235	2819281..2819739	-	459	WP_218313665.1	OsmC family protein	-
KVY02_RS13240	2819803..2820324	-	522	WP_016914639.1	DUF2442 domain-containing protein	Antitoxin
KVY02_RS13245	2820318..2820587	-	270	WP_081139058.1	DUF4160 domain-containing protein	Toxin
KVY02_RS13250	2820754..2821575	+	822	WP_218313666.1	aldo/keto reductase	-
KVY02_RS13255	2821739..2821990	+	252	WP_039176654.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
KVY02_RS13260	2821987..2822241	+	255	WP_218313667.1	Txe/YoeB family addiction module toxin	-
KVY02_RS13265	2822461..2822916	-	456	WP_218313668.1	lysophospholipase	-
KVY02_RS13270	2823023..2823304	-	282	WP_218313669.1	type II toxin-antitoxin system RelE/ParE family toxin	-
KVY02_RS13275	2823301..2823573	-	273	WP_016914646.1	ribbon-helix-helix protein, CopG family	-
KVY02_RS13280	2823759..2824232	-	474	WP_218313670.1	GNAT family N-acetyltransferase	-
KVY02_RS13285	2824339..2824680	-	342	WP_218315091.1	GFA family protein	-
KVY02_RS13290	2824821..2825141	-	321	WP_218313671.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF4160 (9-74)

Antitoxin

• Protein of unknown function DUF2442 (4-59)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10312.91 Da
• Isoelectric Point: 6.7439

>T209032 WP_081139058.1 NZ_CP078120:c2820587-2820318 [Halomonas sp. 18071143]
MPEIDALLGLSFCLYFFDNKQHKLPHLHVKYGSYELIIAIETGECLEGYLPNKQRKRAESHIFDHREQLMVMWHKAVNGE
NPGKLGDVC

Nucleotide

• Length: 270 bp

>T209032 NZ_CP103808:2011262-2011660 [Actinobacillus genomosp. 1]
ATGCTGACTTATATGCTTGATACTAACATTGCGATTTATGTCATTAAACGCAGACCACTTGAAGTGCTGGATAAGTTTAA
TTTAAATTCCACCCGTCTTTGTGTAAGTAGTATCACTGCAGCGGAGCTGTATTATGGGGCAGAGAAAAGCCAGTTTCCGG
AACAGAATATGGCAGTAATTGAGGATTTTCTTTCTCGTTTAACGATTCTTGATTATACGCATAAGGAGGCTACTCACTTT
GGCAATATCAAAGCACATTTATCTAAGCACGGTAAGATTATCGGGGAGAACGATATTCACATTGCCGCACATGCAAGAAG
TGAAGGACTTGTATTAGTAACCAATAACTTGCGTGAATTTGAACGTGTGGAAGGATTACGATTAGCTAATTGGGTATAG

Antitoxin

Protein

• Length: 174 a.a.
• Molecular weight: 19071.62 Da
• Isoelectric Point: 6.7334

>AT209032 WP_016914639.1 NZ_CP078120:c2820324-2819803 [Halomonas sp. 18071143]
MLKIVDVDVISGHALALTFSDGYFGRADLTAYFSKPPFSEIKDFKRFSLTPEGSLNWSGNELSAATLRAITKGEQKSADV
FVNVQEMEAVIKQASWESMKEGRADILQAAIRSYVEQFGHSQVIAKAGIKSRTSAYRSLKPETRPNFDTLVQLGHAVIEL
AQERAVSINESSI

Nucleotide

• Length: 522 bp

>AT209032 NZ_CP103808:2011032-2011262 [Actinobacillus genomosp. 1]
ATGGAAGCATCGGTATTTATGACAAACCGTAGTCAAGCGGTACGATTGCCGGCAGAAGTACGCTTTGCAAGTGATGTAAA
AAAACTTTCTGTAAGAGTAGTCGGTAATGAGCGTATTTTGGCTCCGATTAACCAAAGTTGGGATAGCTTCTTTCTGGGGG
CGGCAACGGTAAGCGATGATTTTATGACAGAGCGTGAAATCAGCATTCAGCCCGAACGTGAGGGACTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A2M9TC71