Detailed information of TA system TA209031

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2708479..2709118
• Replicon: chromosome
• Accession: NZ_CP078120
• Organism: Halomonas sp. 18071143

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: KVY02_RS12680
• Protein ID: WP_081137457.1
• Coordinates: 2708479..2708661 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: KVY02_RS12685
• Protein ID: WP_081137456.1
• Coordinates: 2708699..2709118 (+)
• Length: 140 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KVY02_RS12650	2704057..2705535	-	1479	WP_218313620.1	glutamate--tRNA ligase	-
KVY02_RS12655	2705823..2706347	+	525	WP_016914537.1	helix-turn-helix domain-containing protein	-
KVY02_RS12660	2706369..2706944	-	576	WP_198517461.1	hypothetical protein	-
KVY02_RS12665	2707265..2707627	-	363	WP_039176367.1	helix-turn-helix transcriptional regulator	-
KVY02_RS12670	2707666..2707917	-	252	WP_039176369.1	type II toxin-antitoxin system RelE/ParE family toxin	-
KVY02_RS12675	2708005..2708361	+	357	WP_081137459.1	baseplate J/gp47 family protein	-
KVY02_RS12680	2708479..2708661	+	183	WP_081137457.1	type II toxin-antitoxin system HicA family toxin	Toxin
KVY02_RS12685	2708699..2709118	+	420	WP_081137456.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
KVY02_RS12690	2709283..2709498	-	216	WP_081137454.1	hypothetical protein	-
KVY02_RS12695	2710102..2711043	+	942	WP_081137453.1	DNA (cytosine-5-)-methyltransferase	-
KVY02_RS12700	2711040..2711552	-	513	WP_218313621.1	hypothetical protein	-
KVY02_RS12705	2711671..2713029	-	1359	WP_218313622.1	IS1380 family transposase	-
KVY02_RS12710	2713117..2713755	-	639	WP_218313623.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2705823..2714857	9034

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6685.83 Da
• Isoelectric Point: 11.2210

>T209031 WP_081137457.1 NZ_CP078120:2708479-2708661 [Halomonas sp. 18071143]
VNSRVLIKELEADGWTLLRVKGSHHHFRHPTKPGTITVPHPKKDLKTGLVKGIRKSAGLE

Nucleotide

• Length: 183 bp

>T209031 NZ_CP103808:c1874787-1874425 [Actinobacillus genomosp. 1]
GTGAAGTTAGTTTTTGTAGAATTACCACCTTTTGAGCGATATAGACAAAAGCACCTTAGTGATGAAGAATATAGACATTT
TCAGAATGAGCTATTAGAAAATCCTAATAAAGGAGATTTAATCCAAGGTACGAACGGCTTACGCAAAATTAGAATTGCAG
ATATGCAACGAAATAAAGGTAAGAGAGGTGGAGCAAGGGTAATTTATTATCATATTGTGAATTATTCAAAAATTTTGTTG
GTTACTGCATATGGTAAAGATGAACAATCAGATTTATCTAATACGGAACGCAATATGTTAGCGAATAAAGTGAAGCGTAT
TGTTGAATTAGAGATAAGGAGTTGTAATGGGAAAACTTTTTGA

Antitoxin

Protein

• Length: 140 a.a.
• Molecular weight: 15293.22 Da
• Isoelectric Point: 4.4514

>AT209031 WP_081137456.1 NZ_CP078120:2708699-2709118 [Halomonas sp. 18071143]
MLFPIAIERGDEQHAYGVIVPDLPGCHSAGDTFEEALANAKEAIDGWLEVAVEYGDPIPEATSIEHHMDNPDFTGWIWAV
VDIDVTPYLGKSHKINVTLPDLLVKQIDDFVARHPGDKTRSGFLSRVAMAELARNKQAS

Nucleotide

• Length: 420 bp

>AT209031 NZ_CP103808:c1874441-1874133 [Actinobacillus genomosp. 1]
ATGGGAAAACTTTTTGATGATTTAATGGAAGGGCTTGATGCTTATGAAAAACATATCCAAGGCAAAATCACCCTGCGAAC
CACGGTATTAGAAAAGCCTGAACCAGTAGAACTTAGCCCGTCCGAAGTTAAATCGATTCGAGAAAAATTAAATCTATCGC
AAGCGGTTTTTGCGCATAAATTGCATACCTCCGTGCGGACTTATCAAGGGTGGGAGCAAGGCAAAACCAAACCGAATCCA
CAAGCGGTACTTTTACTACGTATGGTGGACAAATCTCCGCAATTATTAGAACAAATGGCACAGCTCTAA