Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2708479..2709118 Replicon chromosome
Accession NZ_CP078120
Organism Halomonas sp. 18071143

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag KVY02_RS12680 Protein ID WP_081137457.1
Coordinates 2708479..2708661 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KVY02_RS12685 Protein ID WP_081137456.1
Coordinates 2708699..2709118 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KVY02_RS12650 2704057..2705535 - 1479 WP_218313620.1 glutamate--tRNA ligase -
KVY02_RS12655 2705823..2706347 + 525 WP_016914537.1 helix-turn-helix domain-containing protein -
KVY02_RS12660 2706369..2706944 - 576 WP_198517461.1 hypothetical protein -
KVY02_RS12665 2707265..2707627 - 363 WP_039176367.1 helix-turn-helix transcriptional regulator -
KVY02_RS12670 2707666..2707917 - 252 WP_039176369.1 type II toxin-antitoxin system RelE/ParE family toxin -
KVY02_RS12675 2708005..2708361 + 357 WP_081137459.1 baseplate J/gp47 family protein -
KVY02_RS12680 2708479..2708661 + 183 WP_081137457.1 type II toxin-antitoxin system HicA family toxin Toxin
KVY02_RS12685 2708699..2709118 + 420 WP_081137456.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KVY02_RS12690 2709283..2709498 - 216 WP_081137454.1 hypothetical protein -
KVY02_RS12695 2710102..2711043 + 942 WP_081137453.1 DNA (cytosine-5-)-methyltransferase -
KVY02_RS12700 2711040..2711552 - 513 WP_218313621.1 hypothetical protein -
KVY02_RS12705 2711671..2713029 - 1359 WP_218313622.1 IS1380 family transposase -
KVY02_RS12710 2713117..2713755 - 639 WP_218313623.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2705823..2714857 9034


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6685.83 Da        Isoelectric Point: 11.2210

>T209031 WP_081137457.1 NZ_CP078120:2708479-2708661 [Halomonas sp. 18071143]
VNSRVLIKELEADGWTLLRVKGSHHHFRHPTKPGTITVPHPKKDLKTGLVKGIRKSAGLE

Download         Length: 183 bp

>T209031 NZ_CP103808:c1874787-1874425 [Actinobacillus genomosp. 1]
GTGAAGTTAGTTTTTGTAGAATTACCACCTTTTGAGCGATATAGACAAAAGCACCTTAGTGATGAAGAATATAGACATTT
TCAGAATGAGCTATTAGAAAATCCTAATAAAGGAGATTTAATCCAAGGTACGAACGGCTTACGCAAAATTAGAATTGCAG
ATATGCAACGAAATAAAGGTAAGAGAGGTGGAGCAAGGGTAATTTATTATCATATTGTGAATTATTCAAAAATTTTGTTG
GTTACTGCATATGGTAAAGATGAACAATCAGATTTATCTAATACGGAACGCAATATGTTAGCGAATAAAGTGAAGCGTAT
TGTTGAATTAGAGATAAGGAGTTGTAATGGGAAAACTTTTTGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15293.22 Da        Isoelectric Point: 4.4514

>AT209031 WP_081137456.1 NZ_CP078120:2708699-2709118 [Halomonas sp. 18071143]
MLFPIAIERGDEQHAYGVIVPDLPGCHSAGDTFEEALANAKEAIDGWLEVAVEYGDPIPEATSIEHHMDNPDFTGWIWAV
VDIDVTPYLGKSHKINVTLPDLLVKQIDDFVARHPGDKTRSGFLSRVAMAELARNKQAS

Download         Length: 420 bp

>AT209031 NZ_CP103808:c1874441-1874133 [Actinobacillus genomosp. 1]
ATGGGAAAACTTTTTGATGATTTAATGGAAGGGCTTGATGCTTATGAAAAACATATCCAAGGCAAAATCACCCTGCGAAC
CACGGTATTAGAAAAGCCTGAACCAGTAGAACTTAGCCCGTCCGAAGTTAAATCGATTCGAGAAAAATTAAATCTATCGC
AAGCGGTTTTTGCGCATAAATTGCATACCTCCGTGCGGACTTATCAAGGGTGGGAGCAAGGCAAAACCAAACCGAATCCA
CAAGCGGTACTTTTACTACGTATGGTGGACAAATCTCCGCAATTATTAGAACAAATGGCACAGCTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References