Detailed information of TA system TA209030

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-couple_hipB
• Location: 2707265..2707917
• Replicon: chromosome
• Accession: NZ_CP078120
• Organism: Halomonas sp. 18071143

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KVY02_RS12670
• Protein ID: WP_039176369.1
• Coordinates: 2707666..2707917 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: KVY02_RS12665
• Protein ID: WP_039176367.1
• Coordinates: 2707265..2707627 (-)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KVY02_RS12635	2702469..2703350	+	882	WP_218313619.1	NAD(P)-dependent oxidoreductase	-
KVY02_RS12650	2704057..2705535	-	1479	WP_218313620.1	glutamate--tRNA ligase	-
KVY02_RS12655	2705823..2706347	+	525	WP_016914537.1	helix-turn-helix domain-containing protein	-
KVY02_RS12660	2706369..2706944	-	576	WP_198517461.1	hypothetical protein	-
KVY02_RS12665	2707265..2707627	-	363	WP_039176367.1	helix-turn-helix transcriptional regulator	Antitoxin
KVY02_RS12670	2707666..2707917	-	252	WP_039176369.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KVY02_RS12675	2708005..2708361	+	357	WP_081137459.1	baseplate J/gp47 family protein	-
KVY02_RS12680	2708479..2708661	+	183	WP_081137457.1	type II toxin-antitoxin system HicA family toxin	-
KVY02_RS12685	2708699..2709118	+	420	WP_081137456.1	type II toxin-antitoxin system HicB family antitoxin	-
KVY02_RS12690	2709283..2709498	-	216	WP_081137454.1	hypothetical protein	-
KVY02_RS12695	2710102..2711043	+	942	WP_081137453.1	DNA (cytosine-5-)-methyltransferase	-
KVY02_RS12700	2711040..2711552	-	513	WP_218313621.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2705823..2714857	9034

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-78)

Antitoxin

• Cro/C1-type helix-turn-helix domain (65-119)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9525.02 Da
• Isoelectric Point: 10.5610

>T209030 WP_039176369.1 NZ_CP078120:c2707917-2707666 [Halomonas sp. 18071143]
MKTITYRKSALKVLQRMPRPESKRIQGKIKAYAEDPESQRNNVKALKGSDYIRLRVGDWRVIIDEHGDVLDIINIGARGG
VYQ

Nucleotide

• Length: 252 bp

>T209030 NZ_CP103808:c1592799-1592428 [Actinobacillus genomosp. 1]
ATGTATGAAATAGTCTTTTATCGAGATAAACGAGGGCGAGAACCCGTTAAAGAATTTCTGTTAAGGTTGTTAAAAGAACA
GCAGGAAGGCAGTCGAGAACGATTACACAAAATTAGCCATCATTTAAGCATTTTACATTTGCACGGCACTCGTGCCGGCG
AGAATTATATCAAGCATTTGGAAGATCGTATTTGGCAGCTACGTCCGGTCGGTGATTGTCTGTTATTTGCAAGTATCATT
CGAGGTAAATTCGTATTACTGCATTATTTTGCCAAAAATAATTATCGAATTCCGAAACGGGAGATAGAACGTGCAAAAGT
TCGTTTAGCAGATCTACAGGAGAGAATAAAAGATGAGCCCTATTGGTTCTAG

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 12884.59 Da
• Isoelectric Point: 4.1383

>AT209030 WP_039176367.1 NZ_CP078120:c2707627-2707265 [Halomonas sp. 18071143]
MSIPQIIQTPTGERLVVLPEQEYQALLARLEDQDDIDAANAVVARGEESFPVAVVDALLDGVAPVKVYREYRGLRAGELA
EKAGISQGYLSEIESGKKSGSLSVLTRIATALEVELSDLT

Nucleotide

• Length: 363 bp

>AT209030 NZ_CP103808:c1592447-1592154 [Actinobacillus genomosp. 1]
ATGAGCCCTATTGGTTCTAGTTGGACATCGTTTGAACAAGAAATTTTTGACGAGTTGGAAATAGCCGAAACACAATTTCG
CATACGGCTTATTTTAGAGATTATTGAAACCCGTCAGCAACTGGGGATCTCACAAAGAAAGCTGGAAAAATTAAGCGGCG
TGAAACAATCCATGATTGCGCGAGTAGAAAAAGGTTCGGTTAATCCGTCTTTGGCGACTGTATTGAAATTACTCGTTCCG
TTAGGTAAGACTTTACAAATCGTACCGCTGGATAAGCTTAAAGTACCACGTTAA