Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-couple_hipB
Location 2707265..2707917 Replicon chromosome
Accession NZ_CP078120
Organism Halomonas sp. 18071143

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KVY02_RS12670 Protein ID WP_039176369.1
Coordinates 2707666..2707917 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KVY02_RS12665 Protein ID WP_039176367.1
Coordinates 2707265..2707627 (-) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KVY02_RS12635 2702469..2703350 + 882 WP_218313619.1 NAD(P)-dependent oxidoreductase -
KVY02_RS12650 2704057..2705535 - 1479 WP_218313620.1 glutamate--tRNA ligase -
KVY02_RS12655 2705823..2706347 + 525 WP_016914537.1 helix-turn-helix domain-containing protein -
KVY02_RS12660 2706369..2706944 - 576 WP_198517461.1 hypothetical protein -
KVY02_RS12665 2707265..2707627 - 363 WP_039176367.1 helix-turn-helix transcriptional regulator Antitoxin
KVY02_RS12670 2707666..2707917 - 252 WP_039176369.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KVY02_RS12675 2708005..2708361 + 357 WP_081137459.1 baseplate J/gp47 family protein -
KVY02_RS12680 2708479..2708661 + 183 WP_081137457.1 type II toxin-antitoxin system HicA family toxin -
KVY02_RS12685 2708699..2709118 + 420 WP_081137456.1 type II toxin-antitoxin system HicB family antitoxin -
KVY02_RS12690 2709283..2709498 - 216 WP_081137454.1 hypothetical protein -
KVY02_RS12695 2710102..2711043 + 942 WP_081137453.1 DNA (cytosine-5-)-methyltransferase -
KVY02_RS12700 2711040..2711552 - 513 WP_218313621.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2705823..2714857 9034


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-78)

Antitoxin

Cro/C1-type helix-turn-helix domain

(65-119)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9525.02 Da        Isoelectric Point: 10.5610

>T209030 WP_039176369.1 NZ_CP078120:c2707917-2707666 [Halomonas sp. 18071143]
MKTITYRKSALKVLQRMPRPESKRIQGKIKAYAEDPESQRNNVKALKGSDYIRLRVGDWRVIIDEHGDVLDIINIGARGG
VYQ

Download         Length: 252 bp

>T209030 NZ_CP103808:c1592799-1592428 [Actinobacillus genomosp. 1]
ATGTATGAAATAGTCTTTTATCGAGATAAACGAGGGCGAGAACCCGTTAAAGAATTTCTGTTAAGGTTGTTAAAAGAACA
GCAGGAAGGCAGTCGAGAACGATTACACAAAATTAGCCATCATTTAAGCATTTTACATTTGCACGGCACTCGTGCCGGCG
AGAATTATATCAAGCATTTGGAAGATCGTATTTGGCAGCTACGTCCGGTCGGTGATTGTCTGTTATTTGCAAGTATCATT
CGAGGTAAATTCGTATTACTGCATTATTTTGCCAAAAATAATTATCGAATTCCGAAACGGGAGATAGAACGTGCAAAAGT
TCGTTTAGCAGATCTACAGGAGAGAATAAAAGATGAGCCCTATTGGTTCTAG

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 12884.59 Da        Isoelectric Point: 4.1383

>AT209030 WP_039176367.1 NZ_CP078120:c2707627-2707265 [Halomonas sp. 18071143]
MSIPQIIQTPTGERLVVLPEQEYQALLARLEDQDDIDAANAVVARGEESFPVAVVDALLDGVAPVKVYREYRGLRAGELA
EKAGISQGYLSEIESGKKSGSLSVLTRIATALEVELSDLT

Download         Length: 363 bp

>AT209030 NZ_CP103808:c1592447-1592154 [Actinobacillus genomosp. 1]
ATGAGCCCTATTGGTTCTAGTTGGACATCGTTTGAACAAGAAATTTTTGACGAGTTGGAAATAGCCGAAACACAATTTCG
CATACGGCTTATTTTAGAGATTATTGAAACCCGTCAGCAACTGGGGATCTCACAAAGAAAGCTGGAAAAATTAAGCGGCG
TGAAACAATCCATGATTGCGCGAGTAGAAAAAGGTTCGGTTAATCCGTCTTTGGCGACTGTATTGAAATTACTCGTTCCG
TTAGGTAAGACTTTACAAATCGTACCGCTGGATAAGCTTAAAGTACCACGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References