Detailed information of TA system TA209029

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/upstrm_HI1419-dnstrm_HI1420
• Location: 2535452..2536032
• Replicon: chromosome
• Accession: NZ_CP078120
• Organism: Halomonas sp. 18071143

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: KVY02_RS11830
• Protein ID: WP_100732011.1
• Coordinates: 2535730..2536032 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: KVY02_RS11825
• Protein ID: WP_100731997.1
• Coordinates: 2535452..2535733 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KVY02_RS11810	2531823..2532620	+	798	WP_256357485.1	MipA/OmpV family protein	-
KVY02_RS11815	2532685..2534337	+	1653	WP_218313587.1	alpha/beta-hydrolase family protein	-
KVY02_RS11820	2534981..2535133	+	153	WP_081195643.1	metallothionein	-
KVY02_RS11825	2535452..2535733	-	282	WP_100731997.1	putative addiction module antidote protein	Antitoxin
KVY02_RS11830	2535730..2536032	-	303	WP_100732011.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KVY02_RS11840	2536551..2537057	-	507	WP_081195622.1	YiiD C-terminal domain-containing protein	-
KVY02_RS11845	2537082..2537642	-	561	WP_039181222.1	nitroreductase family protein	-
KVY02_RS11850	2537668..2538501	-	834	WP_039181225.1	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF	-
KVY02_RS11855	2538540..2539313	-	774	WP_016914465.1	ABC transporter permease	-
KVY02_RS11860	2539310..2540272	-	963	WP_218313588.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2523496..2544150	20654
	-	flank	IS/Tn	-	-	2530291..2531403	1112

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-92)

Antitoxin

• Uncharacterized protein HI1420 (3-91)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11316.91 Da
• Isoelectric Point: 7.9819

>T209029 WP_100732011.1 NZ_CP078120:c2536032-2535730 [Halomonas sp. 18071143]
MKIISETDTYSDWFDKLRDARARAKILARLRRAELGNFGDCEPVGEGVSELRIHYGPGYRVYFVQRGYELIILLAGGDKS
SQAKDIDIAKQLARDLKEAP

Nucleotide

• Length: 303 bp

>T209029 NZ_CP103808:1504036-1504296 [Actinobacillus genomosp. 1]
ATGAAACTAACTTTCTCGTCTAATGCGTGGGAAGATTATTTATACTGGCAAAAAACCGATAAAATAATTTTGAAACGTAT
AAACAGCCTGATCAAAGATATTCAACGCCAACCATTCGAAGGCATAGGAAAACCGGAGCCGTTAAAATTCAATCTTTCGG
GCTTTTGGTCAAGGCGAATCAATGAAGAACACCGCTTAATTTACAGCGTGGAAGATGAAGCAATTTTAATAGTAGCATGT
AGATACCATTATGATCAGTAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10064.51 Da
• Isoelectric Point: 4.5994

>AT209029 WP_100731997.1 NZ_CP078120:c2535733-2535452 [Halomonas sp. 18071143]
MSTLRKWDVVDHLNTEEEMVLYFEACLEEGDAALVAAALGDIARARGMAQLARDTGLTREGLYKALSADGNPSFATIMKV
TKALGFTLRAEVS

Nucleotide

• Length: 282 bp

>AT209029 NZ_CP103808:1503788-1504039 [Actinobacillus genomosp. 1]
ATGCAAGCAATAACCTACACAGAAGCACGCCAAAATCTAGCCGGTACAATGTCAAAAGTAGCAGAAGATTTTGAGCCTAT
TTTAATTACGAGAAGCAAGGGCGGAAATTGCGTACTTATGTCATATGAGCAGTATTGTTCACTTGAAGAAACAGCCTATT
TAATGCGTTCACCTACCAATGCAAAACGGCTATTGGATAGTGTGGCGGAATTAAGACAGGGACAAGGCATTGAAAGAGAT
TTAATCGAATGA