Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 2535452..2536032 Replicon chromosome
Accession NZ_CP078120
Organism Halomonas sp. 18071143

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag KVY02_RS11830 Protein ID WP_100732011.1
Coordinates 2535730..2536032 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KVY02_RS11825 Protein ID WP_100731997.1
Coordinates 2535452..2535733 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KVY02_RS11810 2531823..2532620 + 798 WP_256357485.1 MipA/OmpV family protein -
KVY02_RS11815 2532685..2534337 + 1653 WP_218313587.1 alpha/beta-hydrolase family protein -
KVY02_RS11820 2534981..2535133 + 153 WP_081195643.1 metallothionein -
KVY02_RS11825 2535452..2535733 - 282 WP_100731997.1 putative addiction module antidote protein Antitoxin
KVY02_RS11830 2535730..2536032 - 303 WP_100732011.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KVY02_RS11840 2536551..2537057 - 507 WP_081195622.1 YiiD C-terminal domain-containing protein -
KVY02_RS11845 2537082..2537642 - 561 WP_039181222.1 nitroreductase family protein -
KVY02_RS11850 2537668..2538501 - 834 WP_039181225.1 NADPH-dependent 7-cyano-7-deazaguanine reductase QueF -
KVY02_RS11855 2538540..2539313 - 774 WP_016914465.1 ABC transporter permease -
KVY02_RS11860 2539310..2540272 - 963 WP_218313588.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2523496..2544150 20654
- flank IS/Tn - - 2530291..2531403 1112


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-92)

Antitoxin

Uncharacterized protein HI1420

(3-91)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11316.91 Da        Isoelectric Point: 7.9819

>T209029 WP_100732011.1 NZ_CP078120:c2536032-2535730 [Halomonas sp. 18071143]
MKIISETDTYSDWFDKLRDARARAKILARLRRAELGNFGDCEPVGEGVSELRIHYGPGYRVYFVQRGYELIILLAGGDKS
SQAKDIDIAKQLARDLKEAP

Download         Length: 303 bp

>T209029 NZ_CP103808:1504036-1504296 [Actinobacillus genomosp. 1]
ATGAAACTAACTTTCTCGTCTAATGCGTGGGAAGATTATTTATACTGGCAAAAAACCGATAAAATAATTTTGAAACGTAT
AAACAGCCTGATCAAAGATATTCAACGCCAACCATTCGAAGGCATAGGAAAACCGGAGCCGTTAAAATTCAATCTTTCGG
GCTTTTGGTCAAGGCGAATCAATGAAGAACACCGCTTAATTTACAGCGTGGAAGATGAAGCAATTTTAATAGTAGCATGT
AGATACCATTATGATCAGTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10064.51 Da        Isoelectric Point: 4.5994

>AT209029 WP_100731997.1 NZ_CP078120:c2535733-2535452 [Halomonas sp. 18071143]
MSTLRKWDVVDHLNTEEEMVLYFEACLEEGDAALVAAALGDIARARGMAQLARDTGLTREGLYKALSADGNPSFATIMKV
TKALGFTLRAEVS

Download         Length: 282 bp

>AT209029 NZ_CP103808:1503788-1504039 [Actinobacillus genomosp. 1]
ATGCAAGCAATAACCTACACAGAAGCACGCCAAAATCTAGCCGGTACAATGTCAAAAGTAGCAGAAGATTTTGAGCCTAT
TTTAATTACGAGAAGCAAGGGCGGAAATTGCGTACTTATGTCATATGAGCAGTATTGTTCACTTGAAGAAACAGCCTATT
TAATGCGTTCACCTACCAATGCAAAACGGCTATTGGATAGTGTGGCGGAATTAAGACAGGGACAAGGCATTGAAAGAGAT
TTAATCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References