Detailed information of TA system TA209028

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 2178404..2178936
• Replicon: chromosome
• Accession: NZ_CP078120
• Organism: Halomonas sp. 18071143

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: KVY02_RS10195
• Protein ID: WP_213262573.1
• Coordinates: 2178643..2178936 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A2M9TDT4
• Locus tag: KVY02_RS10190
• Protein ID: WP_016914150.1
• Coordinates: 2178404..2178643 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KVY02_RS10155	2173627..2174376	+	750	WP_218313481.1	class I SAM-dependent methyltransferase	-
KVY02_RS10160	2174393..2174863	-	471	WP_016914145.1	DUF1456 family protein	-
KVY02_RS10165	2174872..2175294	-	423	WP_218313482.1	tetratricopeptide repeat protein	-
KVY02_RS10170	2175489..2176685	+	1197	WP_016914147.1	DEAD/DEAH box helicase	-
KVY02_RS10175	2176736..2177716	-	981	WP_218313483.1	transcription termination factor Rho	-
KVY02_RS10180	2177785..2177952	-	168	WP_218313484.1	hypothetical protein	-
KVY02_RS10185	2178097..2178309	-	213	WP_218315078.1	Txe/YoeB family addiction module toxin	-
KVY02_RS10190	2178404..2178643	+	240	WP_016914150.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
KVY02_RS10195	2178643..2178936	+	294	WP_213262573.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KVY02_RS10200	2179003..2179302	-	300	WP_086904840.1	type II toxin-antitoxin system RelE/ParE family toxin	-
KVY02_RS10205	2179303..2179572	-	270	WP_086904841.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
KVY02_RS10210	2179714..2180754	-	1041	WP_218313485.1	hypothetical protein	-
KVY02_RS10215	2180951..2182302	+	1352	Protein_1990	IS1380 family transposase	-
KVY02_RS10220	2182534..2183454	+	921	Protein_1991	IS256 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2182732..2183454	722

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-92)

Antitoxin

• Antitoxin ParD (1-77)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11319.97 Da
• Isoelectric Point: 10.6179

>T209028 WP_213262573.1 NZ_CP078120:2178643-2178936 [Halomonas sp. 18071143]
MRPYLLTASARKDVVEIGRFTTEKWGKRQRDTYLRQLDDAFKRLARQPDIGRDAGDIKPGYKKFSQGSHVIFYRAGTESR
IVVIRILHNSMDVEQHL

Nucleotide

• Length: 294 bp

>T209028 NZ_CP103808:1503788-1504039 [Actinobacillus genomosp. 1]
ATGCAAGCAATAACCTACACAGAAGCACGCCAAAATCTAGCCGGTACAATGTCAAAAGTAGCAGAAGATTTTGAGCCTAT
TTTAATTACGAGAAGCAAGGGCGGAAATTGCGTACTTATGTCATATGAGCAGTATTGTTCACTTGAAGAAACAGCCTATT
TAATGCGTTCACCTACCAATGCAAAACGGCTATTGGATAGTGTGGCGGAATTAAGACAGGGACAAGGCATTGAAAGAGAT
TTAATCGAATGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8863.83 Da
• Isoelectric Point: 4.3041

>AT209028 WP_016914150.1 NZ_CP078120:2178404-2178643 [Halomonas sp. 18071143]
MARNTSITLGPHFDEFIATQVEKGRYGSVSEVVRAGLRLLEETESKLERLQRLLDEGEQSGIAEYSLESVITELDNEAH

Nucleotide

• Length: 240 bp

>AT209028 NZ_CP103808:1504036-1504296 [Actinobacillus genomosp. 1]
ATGAAACTAACTTTCTCGTCTAATGCGTGGGAAGATTATTTATACTGGCAAAAAACCGATAAAATAATTTTGAAACGTAT
AAACAGCCTGATCAAAGATATTCAACGCCAACCATTCGAAGGCATAGGAAAACCGGAGCCGTTAAAATTCAATCTTTCGG
GCTTTTGGTCAAGGCGAATCAATGAAGAACACCGCTTAATTTACAGCGTGGAAGATGAAGCAATTTTAATAGTAGCATGT
AGATACCATTATGATCAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A2M9TDT4