Detailed information of TA system TA209026

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 888132..888742
• Replicon: chromosome
• Accession: NZ_CP078120
• Organism: Halomonas sp. 18071143

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: KVY02_RS04325
• Protein ID: WP_170919432.1
• Coordinates: 888314..888742 (-)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: KVY02_RS04320
• Protein ID: WP_081136082.1
• Coordinates: 888132..888317 (-)
• Length: 62 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KVY02_RS04285	883610..884185	-	576	WP_218314503.1	hypothetical protein	-
KVY02_RS04295	884544..885581	+	1038	WP_100731063.1	site-specific integrase	-
KVY02_RS04300	885645..886898	+	1254	WP_081136085.1	alanine racemase	-
KVY02_RS04315	887332..888129	-	798	WP_139788419.1	hypothetical protein	-
KVY02_RS04320	888132..888317	-	186	WP_081136082.1	hypothetical protein	Antitoxin
KVY02_RS04325	888314..888742	-	429	WP_170919432.1	type II toxin-antitoxin system VapC family toxin	Toxin
KVY02_RS04330	888739..888993	-	255	WP_081136080.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
KVY02_RS04335	889475..892741	+	3267	WP_218314504.1	helicase-related protein	-
KVY02_RS04340	892765..893136	+	372	WP_081136077.1	four helix bundle protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15548.86 Da
• Isoelectric Point: 4.9440

>T209026 WP_170919432.1 NZ_CP078120:c888742-888314 [Halomonas sp. 18071143]
MMFVLDTNVVSELRKVRAGKADPNVSAWTESVDAAELFVSAITIMELELGVLSIERKDATQGAVLRSWLEQHVLPEFSGR
TLPVDTAVAQRCARLHVPDKRGERDALIAATALVHGMTVVTRNVADFEPTGVTILNPWEALQ

Nucleotide

• Length: 429 bp

>T209026 NZ_CP103807:1586784-1587032 [Actinobacillus genomosp. 2]
ATGAATAATCCCGAAGCTGGAGATATTGTTCAAGGCATAAACGGTTTACGAAAAATTCGTATATCAACCCAAGCAAGGGG
GAAGAAAGGTGGTGCCAGAGTGATTTACTACTATTATGTTAGAGGATCACAAATTTGGTTATTTACAGGGTATAACAAAT
CAAGAAAAATAGATTTGAATTCAATGGAAAGAAAAGCATTTTCTAAAGTATTAGAACATTTAAAAAATATTGCGGATAGG
GAGCTATAA

Antitoxin

Protein

• Length: 62 a.a.
• Molecular weight: 7020.79 Da
• Isoelectric Point: 4.1064

>AT209026 WP_081136082.1 NZ_CP078120:c888317-888132 [Halomonas sp. 18071143]
MKERIHDDAIVQPDERIKLGSLLQSIAREAGGLTDAEAEYFDQLRDETPAEPMRFECQWEA

Nucleotide

• Length: 186 bp

>AT209026 NZ_CP103807:1587033-1587341 [Actinobacillus genomosp. 2]
ATGGGACGTTTATTTGATGATCTAATGGAAGGGGCGGAAGCCTTAGAACAATACCTTCAAGGCAAAATCACCCTGAGAAC
CACGGTATTAGAAAAGCCTGAACCGATAGAACTTAGCCCGTCTGAAGTTAAATCGATTCGAGAAAAATTAAATCTGTCGC
AAGCGGTTTTTGCACATAAATTACATACCTCCGTGCGGACTTATCAAGGGTGGGAACAAGGTAAAACCAAACCGAATCCA
CAAGCTACTTTGTTATTACGAATGGTAGACAAATCTCCGCAATTATTAGAACAAATGGCACAGCTCTAA