Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-StbC |
| Location | 1976069..1976724 | Replicon | chromosome |
| Accession | NZ_CP078119 | ||
| Organism | Neisseria gonorrhoeae strain 1291 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | Q5F882 |
| Locus tag | KWY98_RS10230 | Protein ID | WP_003691083.1 |
| Coordinates | 1976069..1976488 (-) | Length | 140 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | Q5F881 |
| Locus tag | KWY98_RS10235 | Protein ID | WP_003688410.1 |
| Coordinates | 1976488..1976724 (-) | Length | 79 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KWY98_RS10210 (KWY98_10210) | 1971303..1972844 | - | 1542 | WP_003688418.1 | MDR family MFS transporter | - |
| KWY98_RS10215 (KWY98_10215) | 1972992..1973771 | + | 780 | WP_003688416.1 | (Fe-S)-binding protein | - |
| KWY98_RS10220 (KWY98_10220) | 1973768..1974469 | + | 702 | WP_003688414.1 | lactate utilization protein C | - |
| KWY98_RS10225 (KWY98_10225) | 1974466..1975920 | + | 1455 | WP_003688412.1 | LutB/LldF family L-lactate oxidation iron-sulfur protein | - |
| KWY98_RS10230 (KWY98_10230) | 1976069..1976488 | - | 420 | WP_003691083.1 | type II toxin-antitoxin system toxin FitB | Toxin |
| KWY98_RS10235 (KWY98_10235) | 1976488..1976724 | - | 237 | WP_003688410.1 | type II toxin-antitoxin system antitoxin FitA | Antitoxin |
| KWY98_RS10245 (KWY98_10245) | 1977172..1977750 | - | 579 | WP_003688041.1 | IS3 family transposase | - |
| KWY98_RS10250 (KWY98_10250) | 1977755..1978156 | - | 402 | WP_256346259.1 | helix-turn-helix domain-containing protein | - |
| KWY98_RS10255 (KWY98_10255) | 1978395..1978781 | + | 387 | Protein_2008 | transposase | - |
| KWY98_RS10260 (KWY98_10260) | 1979164..1980054 | - | 891 | WP_003688409.1 | succinate--CoA ligase subunit alpha | - |
| KWY98_RS10265 (KWY98_10265) | 1980065..1981231 | - | 1167 | WP_003688408.1 | ADP-forming succinate--CoA ligase subunit beta | - |
| KWY98_RS10270 (KWY98_10270) | 1981303..1981590 | - | 288 | WP_003688407.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 140 a.a. Molecular weight: 15306.65 Da Isoelectric Point: 6.0798
>T209023 WP_003691083.1 NZ_CP078119:c1976488-1976069 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD
Download Length: 420 bp
>T209023 NZ_CP103807:69560-69940 [Actinobacillus genomosp. 2]
ATGTATTTATTAGATACCAATATTGTTTCCGAACTACTTAAGATGGAAAGCGGAAAAGCCGATGCTTATTTAAGTGTCAT
CACGCTCTTTGAAATTAAGTTAGGGATTTTGCAACTTAAACGCAAAGATATTCAACAAGCTAAACTTTTACAAAGTTGGT
TTGAACAAAAACTCCTGCCCCATTTTGAAAATAGAATTTTACCGCTTGATACGAAAGTTATGATGACCTGTGCAGAGTTT
CATATTCCGGATAAAAAGCCGTTAAATGACTCTTATATAGCTGCTACGGCTAAAGCACATAGGTTTAAAATTGTGACGAG
AAACGTGAAAGATTTTAAAGGATGTGGGGTAGAGGTACTAAATCCATTTATTGATGAATAA
ATGTATTTATTAGATACCAATATTGTTTCCGAACTACTTAAGATGGAAAGCGGAAAAGCCGATGCTTATTTAAGTGTCAT
CACGCTCTTTGAAATTAAGTTAGGGATTTTGCAACTTAAACGCAAAGATATTCAACAAGCTAAACTTTTACAAAGTTGGT
TTGAACAAAAACTCCTGCCCCATTTTGAAAATAGAATTTTACCGCTTGATACGAAAGTTATGATGACCTGTGCAGAGTTT
CATATTCCGGATAAAAAGCCGTTAAATGACTCTTATATAGCTGCTACGGCTAAAGCACATAGGTTTAAAATTGTGACGAG
AAACGTGAAAGATTTTAAAGGATGTGGGGTAGAGGTACTAAATCCATTTATTGATGAATAA
Antitoxin
Download Length: 79 a.a. Molecular weight: 8433.57 Da Isoelectric Point: 7.0129
>AT209023 WP_003688410.1 NZ_CP078119:c1976724-1976488 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL
Download Length: 237 bp
>AT209023 NZ_CP103807:69273-69560 [Actinobacillus genomosp. 2]
ATGGCAGTAATTAGTTCCAAAGAATTTAACCAACGTGCCAGTGCGGTATTAAAAATTGCTGAAACCGAGCCGGTGTATAT
TACTAAATGGGGCAAGGTGGTTAGTGTGTTGGCAAGTTATGCCCATTATCAAGCTCAAACGAAATCACAAAGTTTAGCGG
AGGCTTTTAGCAGTACAGCTCCAACAGAAATATTAAGTGAAGAAGCGGAGCAGCAATTTGAGCAAACTTTGCAACAAGTA
CGCCAACAAATCAAAATAAGAGTACCGGATTTATCGGAGTGGGAATAA
ATGGCAGTAATTAGTTCCAAAGAATTTAACCAACGTGCCAGTGCGGTATTAAAAATTGCTGAAACCGAGCCGGTGTATAT
TACTAAATGGGGCAAGGTGGTTAGTGTGTTGGCAAGTTATGCCCATTATCAAGCTCAAACGAAATCACAAAGTTTAGCGG
AGGCTTTTAGCAGTACAGCTCCAACAGAAATATTAAGTGAAGAAGCGGAGCAGCAATTTGAGCAAACTTTGCAACAAGTA
CGCCAACAAATCAAAATAAGAGTACCGGATTTATCGGAGTGGGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|