Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 2153039..2153724 | Replicon | chromosome |
| Accession | NZ_CP078118 | ||
| Organism | Neisseria gonorrhoeae strain MS11 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | Q5F6D1 |
| Locus tag | KWY99_RS11240 | Protein ID | WP_003689143.1 |
| Coordinates | 2153542..2153724 (-) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | Q5F6D2 |
| Locus tag | KWY99_RS11235 | Protein ID | WP_003691454.1 |
| Coordinates | 2153039..2153440 (-) | Length | 134 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KWY99_RS11185 (KWY99_11185) | 2148514..2148729 | - | 216 | WP_003691538.1 | hypothetical protein | - |
| KWY99_RS11190 (KWY99_11190) | 2148781..2149272 | - | 492 | WP_017147227.1 | siphovirus Gp157 family protein | - |
| KWY99_RS11195 (KWY99_11195) | 2149269..2149451 | - | 183 | WP_003691535.1 | hypothetical protein | - |
| KWY99_RS11200 (KWY99_11200) | 2149591..2150277 | - | 687 | WP_010951053.1 | hypothetical protein | - |
| KWY99_RS11205 (KWY99_11205) | 2150346..2150507 | - | 162 | WP_003691530.1 | hypothetical protein | - |
| KWY99_RS11210 (KWY99_11210) | 2150504..2150779 | - | 276 | WP_003695501.1 | hypothetical protein | - |
| KWY99_RS11215 (KWY99_11215) | 2150932..2151264 | - | 333 | WP_003695500.1 | hypothetical protein | - |
| KWY99_RS11220 (KWY99_11220) | 2151405..2151605 | - | 201 | WP_003695499.1 | hypothetical protein | - |
| KWY99_RS11225 (KWY99_11225) | 2151847..2152263 | - | 417 | WP_003695497.1 | hypothetical protein | - |
| KWY99_RS11230 (KWY99_11230) | 2152272..2152856 | - | 585 | WP_003693477.1 | Panacea domain-containing protein | - |
| KWY99_RS11235 (KWY99_11235) | 2153039..2153440 | - | 402 | WP_003691454.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| KWY99_RS11240 (KWY99_11240) | 2153542..2153724 | - | 183 | WP_003689143.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| KWY99_RS11245 (KWY99_11245) | 2153894..2154724 | - | 831 | WP_003695494.1 | DUF3037 domain-containing protein | - |
| KWY99_RS11250 (KWY99_11250) | 2154987..2155742 | - | 756 | WP_003693472.1 | LexA family transcriptional regulator | - |
| KWY99_RS11255 (KWY99_11255) | 2155882..2156067 | + | 186 | WP_002238713.1 | Cro/CI family transcriptional regulator | - |
| KWY99_RS11260 (KWY99_11260) | 2156156..2156311 | + | 156 | WP_003689578.1 | hypothetical protein | - |
| KWY99_RS11265 (KWY99_11265) | 2156288..2156476 | - | 189 | WP_003696008.1 | hypothetical protein | - |
| KWY99_RS11270 (KWY99_11270) | 2156650..2156877 | + | 228 | WP_017147225.1 | helix-turn-helix domain-containing protein | - |
| KWY99_RS11275 (KWY99_11275) | 2156874..2157011 | + | 138 | WP_017147224.1 | hypothetical protein | - |
| KWY99_RS11280 (KWY99_11280) | 2156995..2158059 | + | 1065 | WP_003689134.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 2138285..2171727 | 33442 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6687.77 Da Isoelectric Point: 10.7235
>T209021 WP_003689143.1 NZ_CP078118:c2153724-2153542 [Neisseria gonorrhoeae]
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK
Download Length: 183 bp
>T209021 NZ_CP103792:c232864-232448 [Salmonella enterica subsp. enterica serovar Infantis]
GTGAAGAAAATGTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCCGAAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCACCGTATTGTGGTCTCGGCCATCACCTACTCAGAGATGCGCTTCGGCGCCACCGGCA
CGAAGGCCTCGCCGCGTCACATTGAACTGGTTGACGCGTTCTGCGCCCGCCTCGATGCTATCCTGCCCTGGGACCGGGCC
GCGGTGAACGCCACCACGGAGATTAAGGTGGCGCTACGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCGATCGC
CGGGCACGCTATTGCCGCCGGCGCGGTACTGGTGACAAATAATACGCGGGAGTTTGAGCGGGTGCCGGGTCTTGTTCTGG
AAGACTGGGGAAGATAA
GTGAAGAAAATGTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCCGAAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCACCGTATTGTGGTCTCGGCCATCACCTACTCAGAGATGCGCTTCGGCGCCACCGGCA
CGAAGGCCTCGCCGCGTCACATTGAACTGGTTGACGCGTTCTGCGCCCGCCTCGATGCTATCCTGCCCTGGGACCGGGCC
GCGGTGAACGCCACCACGGAGATTAAGGTGGCGCTACGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCGATCGC
CGGGCACGCTATTGCCGCCGGCGCGGTACTGGTGACAAATAATACGCGGGAGTTTGAGCGGGTGCCGGGTCTTGTTCTGG
AAGACTGGGGAAGATAA
Antitoxin
Download Length: 134 a.a. Molecular weight: 14634.43 Da Isoelectric Point: 4.5457
>AT209021 WP_003691454.1 NZ_CP078118:c2153440-2153039 [Neisseria gonorrhoeae]
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA
Download Length: 402 bp
>AT209021 NZ_CP103792:c233091-232861 [Salmonella enterica subsp. enterica serovar Infantis]
ATGAGAACCGTATCTATTTTTAAAAACGGCAACAACCGCGCCATCCGCCTTCCCCGCGATCTGGATTTTGATGGAGTGAG
CGAGCTGGAAATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCTGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTCG
AAAAAGCTGACCCGGGCTTTATGGCGGAGCGTGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA
ATGAGAACCGTATCTATTTTTAAAAACGGCAACAACCGCGCCATCCGCCTTCCCCGCGATCTGGATTTTGATGGAGTGAG
CGAGCTGGAAATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCTGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTCG
AAAAAGCTGACCCGGGCTTTATGGCGGAGCGTGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|