Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1778578..1779263 | Replicon | chromosome |
| Accession | NZ_CP078117 | ||
| Organism | Neisseria gonorrhoeae strain SK92679 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | Q5F6D1 |
| Locus tag | KWY95_RS09320 | Protein ID | WP_003689143.1 |
| Coordinates | 1778578..1778760 (+) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | Q5F6D2 |
| Locus tag | KWY95_RS09325 | Protein ID | WP_003691454.1 |
| Coordinates | 1778862..1779263 (+) | Length | 134 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KWY95_RS09280 (KWY95_09280) | 1773822..1774844 | - | 1023 | WP_218423502.1 | helix-turn-helix domain-containing protein | - |
| KWY95_RS09285 (KWY95_09285) | 1774841..1775068 | - | 228 | WP_003691442.1 | helix-turn-helix domain-containing protein | - |
| KWY95_RS09290 (KWY95_09290) | 1775242..1775430 | + | 189 | WP_218423504.1 | hypothetical protein | - |
| KWY95_RS09295 (KWY95_09295) | 1775407..1775562 | - | 156 | WP_004466446.1 | hypothetical protein | - |
| KWY95_RS09300 (KWY95_09300) | 1775642..1775830 | - | 189 | WP_003689136.1 | helix-turn-helix domain-containing protein | - |
| KWY95_RS09305 (KWY95_09305) | 1775946..1776656 | + | 711 | WP_218423505.1 | helix-turn-helix transcriptional regulator | - |
| KWY95_RS09310 (KWY95_09310) | 1776895..1777593 | + | 699 | WP_003689139.1 | hypothetical protein | - |
| KWY95_RS09315 (KWY95_09315) | 1777578..1778408 | + | 831 | WP_003701455.1 | DUF3037 domain-containing protein | - |
| KWY95_RS09320 (KWY95_09320) | 1778578..1778760 | + | 183 | WP_003689143.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| KWY95_RS09325 (KWY95_09325) | 1778862..1779263 | + | 402 | WP_003691454.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| KWY95_RS09330 (KWY95_09330) | 1779362..1780123 | - | 762 | WP_012503753.1 | hypothetical protein | - |
| KWY95_RS09335 (KWY95_09335) | 1780334..1780534 | + | 201 | WP_047920246.1 | hypothetical protein | - |
| KWY95_RS09340 (KWY95_09340) | 1780567..1781043 | + | 477 | WP_002255718.1 | hypothetical protein | - |
| KWY95_RS09345 (KWY95_09345) | 1781040..1781327 | + | 288 | WP_218423507.1 | hypothetical protein | - |
| KWY95_RS09350 (KWY95_09350) | 1781469..1781801 | + | 333 | WP_003698216.1 | hypothetical protein | - |
| KWY95_RS09355 (KWY95_09355) | 1781956..1782231 | + | 276 | WP_050154389.1 | hypothetical protein | - |
| KWY95_RS09360 (KWY95_09360) | 1782228..1782389 | + | 162 | WP_003693867.1 | hypothetical protein | - |
| KWY95_RS09365 (KWY95_09365) | 1782458..1783144 | + | 687 | WP_012503754.1 | hypothetical protein | - |
| KWY95_RS09370 (KWY95_09370) | 1783284..1783466 | + | 183 | WP_003691535.1 | hypothetical protein | - |
| KWY95_RS09375 (KWY95_09375) | 1783463..1783954 | + | 492 | WP_218423509.1 | siphovirus Gp157 family protein | - |
| KWY95_RS09380 (KWY95_09380) | 1784006..1784221 | + | 216 | WP_003691538.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1739853..1798025 | 58172 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6687.77 Da Isoelectric Point: 10.7235
>T209019 WP_003689143.1 NZ_CP078117:1778578-1778760 [Neisseria gonorrhoeae]
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK
Download Length: 183 bp
>T209019 NZ_CP103792:198619-198951 [Salmonella enterica subsp. enterica serovar Infantis]
ATGGACAGAGGGGAAATCTGGCTCGTCTCACTGGATCCTACAGCCGGACATGAACAAAGCGGAAAACGTCCGGTACTTAT
CGTTTCTCCGGCATCATTTAATAAGTTCACCCGGTTACCCGTTGTCGTTCCCGTCACCAGCGGCGGAGACTTTGCCCGCA
CAGCCGGTTTTACCGTCTCCCTGGACGGCGCGGGAACAAAAACAACGGGTGTTATTCGCTGCGACCAGCCCAGAACGATT
GATATGGGTGCCCGGAATGGTAAGCGTCTGGAACGTATACCCGAAGCTGTCGTAAATGAAGTGCTGGCCCGACTGGAAGC
CATTCTGAGCTGA
ATGGACAGAGGGGAAATCTGGCTCGTCTCACTGGATCCTACAGCCGGACATGAACAAAGCGGAAAACGTCCGGTACTTAT
CGTTTCTCCGGCATCATTTAATAAGTTCACCCGGTTACCCGTTGTCGTTCCCGTCACCAGCGGCGGAGACTTTGCCCGCA
CAGCCGGTTTTACCGTCTCCCTGGACGGCGCGGGAACAAAAACAACGGGTGTTATTCGCTGCGACCAGCCCAGAACGATT
GATATGGGTGCCCGGAATGGTAAGCGTCTGGAACGTATACCCGAAGCTGTCGTAAATGAAGTGCTGGCCCGACTGGAAGC
CATTCTGAGCTGA
Antitoxin
Download Length: 134 a.a. Molecular weight: 14634.43 Da Isoelectric Point: 4.5457
>AT209019 WP_003691454.1 NZ_CP078117:1778862-1779263 [Neisseria gonorrhoeae]
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA
Download Length: 402 bp
>AT209019 NZ_CP103792:198361-198618 [Salmonella enterica subsp. enterica serovar Infantis]
ATGTATACCACTCGTCTGAAAAAGGTTGGCGGATCCGTCATGCTGGCGGTTCCTCCCGCCGTGTTGAAAACGCTGGCTCT
GTCGACAGACAGCGAAGTGGGAATGACCATTGATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCCCGTTATTCGC
TTGAGGAACTGCTGGCACAGTGCGATCCGCACGCCGAAATGAGCGATGAGGATAGGGAATGGATGGATGCGCCTGCAGTG
GGTAAGGAGATCCTGTAA
ATGTATACCACTCGTCTGAAAAAGGTTGGCGGATCCGTCATGCTGGCGGTTCCTCCCGCCGTGTTGAAAACGCTGGCTCT
GTCGACAGACAGCGAAGTGGGAATGACCATTGATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCCCGTTATTCGC
TTGAGGAACTGCTGGCACAGTGCGATCCGCACGCCGAAATGAGCGATGAGGATAGGGAATGGATGGATGCGCCTGCAGTG
GGTAAGGAGATCCTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|