Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 436944..437629 | Replicon | chromosome |
| Accession | NZ_CP078116 | ||
| Organism | Neisseria gonorrhoeae strain 88G285 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | Q5F6D1 |
| Locus tag | KWY96_RS02260 | Protein ID | WP_003689143.1 |
| Coordinates | 437447..437629 (-) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | Q5F6D2 |
| Locus tag | KWY96_RS02255 | Protein ID | WP_003691454.1 |
| Coordinates | 436944..437345 (-) | Length | 134 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KWY96_RS02200 (KWY96_02200) | 431978..432193 | - | 216 | WP_003691538.1 | hypothetical protein | - |
| KWY96_RS02205 (KWY96_02205) | 432245..432736 | - | 492 | WP_218422935.1 | siphovirus Gp157 family protein | - |
| KWY96_RS02210 (KWY96_02210) | 432733..432915 | - | 183 | WP_003691535.1 | hypothetical protein | - |
| KWY96_RS02215 (KWY96_02215) | 433056..433742 | - | 687 | WP_010357532.1 | hypothetical protein | - |
| KWY96_RS02220 (KWY96_02220) | 433811..433972 | - | 162 | WP_003691530.1 | hypothetical protein | - |
| KWY96_RS02225 (KWY96_02225) | 433969..434244 | - | 276 | WP_048654501.1 | hypothetical protein | - |
| KWY96_RS02230 (KWY96_02230) | 434397..434729 | - | 333 | WP_033910331.1 | phage associated protein | - |
| KWY96_RS02235 (KWY96_02235) | 434870..435157 | - | 288 | WP_218422916.1 | hypothetical protein | - |
| KWY96_RS02240 (KWY96_02240) | 435154..435630 | - | 477 | WP_002255718.1 | hypothetical protein | - |
| KWY96_RS02245 (KWY96_02245) | 435663..435863 | - | 201 | WP_048654497.1 | hypothetical protein | - |
| KWY96_RS02250 (KWY96_02250) | 436084..436845 | + | 762 | WP_012503753.1 | hypothetical protein | - |
| KWY96_RS02255 (KWY96_02255) | 436944..437345 | - | 402 | WP_003691454.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| KWY96_RS02260 (KWY96_02260) | 437447..437629 | - | 183 | WP_003689143.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| KWY96_RS02265 (KWY96_02265) | 437799..438617 | - | 819 | WP_218422936.1 | DUF3037 domain-containing protein | - |
| KWY96_RS02270 (KWY96_02270) | 438614..439312 | - | 699 | WP_218422937.1 | hypothetical protein | - |
| KWY96_RS02275 (KWY96_02275) | 439549..440247 | - | 699 | WP_082283245.1 | S24 family peptidase | - |
| KWY96_RS02280 (KWY96_02280) | 440287..440940 | - | 654 | WP_157149898.1 | helix-turn-helix transcriptional regulator | - |
| KWY96_RS02285 (KWY96_02285) | 441189..441323 | + | 135 | WP_229684436.1 | YdaS family helix-turn-helix protein | - |
| KWY96_RS02290 (KWY96_02290) | 441325..441525 | + | 201 | WP_012503750.1 | hypothetical protein | - |
| KWY96_RS02295 (KWY96_02295) | 441722..442612 | + | 891 | WP_218422938.1 | replication protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 419393..476845 | 57452 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6687.77 Da Isoelectric Point: 10.7235
>T209016 WP_003689143.1 NZ_CP078116:c437629-437447 [Neisseria gonorrhoeae]
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK
Download Length: 183 bp
>T209016 NZ_CP103791:c3965418-3965134 [Salmonella enterica subsp. enterica serovar Infantis]
ATGAATTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGATCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTTGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG
ATGAATTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGATCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTTGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG
Antitoxin
Download Length: 134 a.a. Molecular weight: 14634.43 Da Isoelectric Point: 4.5457
>AT209016 WP_003691454.1 NZ_CP078116:c437345-436944 [Neisseria gonorrhoeae]
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA
Download Length: 402 bp
>AT209016 NZ_CP103791:c3965650-3965408 [Salmonella enterica subsp. enterica serovar Infantis]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCCTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGAATTA
TGA
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCCTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGAATTA
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|