Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-StbC |
Location | 245486..246141 | Replicon | chromosome |
Accession | NZ_CP078115 | ||
Organism | Neisseria gonorrhoeae strain O1G1370 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | Q5F882 |
Locus tag | KWZ00_RS01375 | Protein ID | WP_003691083.1 |
Coordinates | 245722..246141 (+) | Length | 140 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | Q5F881 |
Locus tag | KWZ00_RS01370 | Protein ID | WP_003688410.1 |
Coordinates | 245486..245722 (+) | Length | 79 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KWZ00_RS01335 (KWZ00_01335) | 240620..240907 | + | 288 | WP_025455945.1 | hypothetical protein | - |
KWZ00_RS01340 (KWZ00_01340) | 240979..242145 | + | 1167 | WP_003701280.1 | ADP-forming succinate--CoA ligase subunit beta | - |
KWZ00_RS01345 (KWZ00_01345) | 242156..243046 | + | 891 | WP_003693285.1 | succinate--CoA ligase subunit alpha | - |
KWZ00_RS01350 (KWZ00_01350) | 243429..243815 | - | 387 | Protein_264 | transposase | - |
KWZ00_RS01355 (KWZ00_01355) | 244054..244455 | + | 402 | WP_020996834.1 | helix-turn-helix domain-containing protein | - |
KWZ00_RS01360 (KWZ00_01360) | 244460..245038 | + | 579 | WP_003697246.1 | IS3 family transposase | - |
KWZ00_RS01370 (KWZ00_01370) | 245486..245722 | + | 237 | WP_003688410.1 | type II toxin-antitoxin system antitoxin FitA | Antitoxin |
KWZ00_RS01375 (KWZ00_01375) | 245722..246141 | + | 420 | WP_003691083.1 | type II toxin-antitoxin system toxin FitB | Toxin |
KWZ00_RS01380 (KWZ00_01380) | 246290..247744 | - | 1455 | WP_003688412.1 | LutB/LldF family L-lactate oxidation iron-sulfur protein | - |
KWZ00_RS01385 (KWZ00_01385) | 247741..248442 | - | 702 | WP_003688414.1 | lactate utilization protein C | - |
KWZ00_RS01390 (KWZ00_01390) | 248439..249218 | - | 780 | WP_003688416.1 | (Fe-S)-binding protein | - |
KWZ00_RS01395 (KWZ00_01395) | 249366..250907 | + | 1542 | WP_003701286.1 | MDR family MFS transporter | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 140 a.a. Molecular weight: 15306.65 Da Isoelectric Point: 6.0798
>T209015 WP_003691083.1 NZ_CP078115:245722-246141 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD
Download Length: 420 bp
>T209015 NZ_CP103791:c2784042-2783939 [Salmonella enterica subsp. enterica serovar Infantis]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT
Antitoxin
Download Length: 79 a.a. Molecular weight: 8433.57 Da Isoelectric Point: 7.0129
>AT209015 WP_003688410.1 NZ_CP078115:245486-245722 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL
Download Length: 237 bp
>AT209015 NZ_CP103791:2783937-2784080 [Salmonella enterica subsp. enterica serovar Infantis]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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