Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 245486..246141 Replicon chromosome
Accession NZ_CP078115
Organism Neisseria gonorrhoeae strain O1G1370

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag KWZ00_RS01375 Protein ID WP_003691083.1
Coordinates 245722..246141 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag KWZ00_RS01370 Protein ID WP_003688410.1
Coordinates 245486..245722 (+) Length 79 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KWZ00_RS01335 (KWZ00_01335) 240620..240907 + 288 WP_025455945.1 hypothetical protein -
KWZ00_RS01340 (KWZ00_01340) 240979..242145 + 1167 WP_003701280.1 ADP-forming succinate--CoA ligase subunit beta -
KWZ00_RS01345 (KWZ00_01345) 242156..243046 + 891 WP_003693285.1 succinate--CoA ligase subunit alpha -
KWZ00_RS01350 (KWZ00_01350) 243429..243815 - 387 Protein_264 transposase -
KWZ00_RS01355 (KWZ00_01355) 244054..244455 + 402 WP_020996834.1 helix-turn-helix domain-containing protein -
KWZ00_RS01360 (KWZ00_01360) 244460..245038 + 579 WP_003697246.1 IS3 family transposase -
KWZ00_RS01370 (KWZ00_01370) 245486..245722 + 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
KWZ00_RS01375 (KWZ00_01375) 245722..246141 + 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
KWZ00_RS01380 (KWZ00_01380) 246290..247744 - 1455 WP_003688412.1 LutB/LldF family L-lactate oxidation iron-sulfur protein -
KWZ00_RS01385 (KWZ00_01385) 247741..248442 - 702 WP_003688414.1 lactate utilization protein C -
KWZ00_RS01390 (KWZ00_01390) 248439..249218 - 780 WP_003688416.1 (Fe-S)-binding protein -
KWZ00_RS01395 (KWZ00_01395) 249366..250907 + 1542 WP_003701286.1 MDR family MFS transporter -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-124)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T209015 WP_003691083.1 NZ_CP078115:245722-246141 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

>T209015 NZ_CP103791:c2784042-2783939 [Salmonella enterica subsp. enterica serovar Infantis]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT209015 WP_003688410.1 NZ_CP078115:245486-245722 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp

>AT209015 NZ_CP103791:2783937-2784080 [Salmonella enterica subsp. enterica serovar Infantis]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O


Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References