Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 2063896..2064581 | Replicon | chromosome |
| Accession | NZ_CP078113 | ||
| Organism | Neisseria gonorrhoeae strain O2D156 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | Q5F6D1 |
| Locus tag | KWY94_RS10735 | Protein ID | WP_003689143.1 |
| Coordinates | 2064399..2064581 (-) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | Q5F6D2 |
| Locus tag | KWY94_RS10730 | Protein ID | WP_003691454.1 |
| Coordinates | 2063896..2064297 (-) | Length | 134 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KWY94_RS10675 (KWY94_10675) | 2058939..2059154 | - | 216 | WP_003691538.1 | hypothetical protein | - |
| KWY94_RS10680 (KWY94_10680) | 2059206..2059697 | - | 492 | WP_003696912.1 | siphovirus Gp157 family protein | - |
| KWY94_RS10685 (KWY94_10685) | 2059694..2059876 | - | 183 | WP_003691535.1 | hypothetical protein | - |
| KWY94_RS10690 (KWY94_10690) | 2060016..2060702 | - | 687 | WP_218461093.1 | hypothetical protein | - |
| KWY94_RS10695 (KWY94_10695) | 2060771..2060932 | - | 162 | WP_003693867.1 | hypothetical protein | - |
| KWY94_RS10700 (KWY94_10700) | 2060929..2061207 | - | 279 | WP_144894338.1 | hypothetical protein | - |
| KWY94_RS10705 (KWY94_10705) | 2061360..2061692 | - | 333 | WP_010357536.1 | hypothetical protein | - |
| KWY94_RS10710 (KWY94_10710) | 2061834..2062109 | - | 276 | WP_047925817.1 | hypothetical protein | - |
| KWY94_RS10715 (KWY94_10715) | 2062106..2062582 | - | 477 | WP_002255718.1 | hypothetical protein | - |
| KWY94_RS10720 (KWY94_10720) | 2062615..2062815 | - | 201 | WP_003704298.1 | hypothetical protein | - |
| KWY94_RS10725 (KWY94_10725) | 2063036..2063797 | + | 762 | WP_012503753.1 | hypothetical protein | - |
| KWY94_RS10730 (KWY94_10730) | 2063896..2064297 | - | 402 | WP_003691454.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| KWY94_RS10735 (KWY94_10735) | 2064399..2064581 | - | 183 | WP_003689143.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| KWY94_RS10740 (KWY94_10740) | 2064751..2065581 | - | 831 | WP_003701455.1 | DUF3037 domain-containing protein | - |
| KWY94_RS10745 (KWY94_10745) | 2065566..2066264 | - | 699 | WP_003689139.1 | hypothetical protein | - |
| KWY94_RS10750 (KWY94_10750) | 2066503..2067201 | - | 699 | WP_002212401.1 | S24 family peptidase | - |
| KWY94_RS10755 (KWY94_10755) | 2067241..2067894 | - | 654 | WP_157149898.1 | helix-turn-helix transcriptional regulator | - |
| KWY94_RS10760 (KWY94_10760) | 2068143..2068277 | + | 135 | WP_229684436.1 | YdaS family helix-turn-helix protein | - |
| KWY94_RS10765 (KWY94_10765) | 2068279..2068479 | + | 201 | WP_012503750.1 | hypothetical protein | - |
| KWY94_RS10770 (KWY94_10770) | 2068676..2069575 | + | 900 | WP_218461094.1 | replication protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 2050417..2084102 | 33685 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6687.77 Da Isoelectric Point: 10.7235
>T209012 WP_003689143.1 NZ_CP078113:c2064581-2064399 [Neisseria gonorrhoeae]
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK
Download Length: 183 bp
>T209012 NZ_CP103791:c1245881-1245624 [Salmonella enterica subsp. enterica serovar Infantis]
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCGAAACCTGCATGACCACCAGTTACTCACATATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCGCAGCGTGACCGTGAAGATTTCACAGGGGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAGCAGAAGCTGCGCGAACAGCTTTACAAGGCTGAACAGGTGGTTAAGGGGATG
CGGGACGTGATTGTTTAG
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCGAAACCTGCATGACCACCAGTTACTCACATATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCGCAGCGTGACCGTGAAGATTTCACAGGGGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAGCAGAAGCTGCGCGAACAGCTTTACAAGGCTGAACAGGTGGTTAAGGGGATG
CGGGACGTGATTGTTTAG
Antitoxin
Download Length: 134 a.a. Molecular weight: 14634.43 Da Isoelectric Point: 4.5457
>AT209012 WP_003691454.1 NZ_CP078113:c2064297-2063896 [Neisseria gonorrhoeae]
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA
Download Length: 402 bp
>AT209012 NZ_CP103791:1245706-1246038 [Salmonella enterica subsp. enterica serovar Infantis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCTCGGCCAGCACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCTCGGCCAGCACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|