Detailed information of TA system TA209010

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 102663..104266
• Replicon: plasmid pH322_2
• Accession: NZ_CP078112
• Organism: Cronobacter sakazakii strain MOD1-H322

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: BTK77_RS21735
• Protein ID: WP_080322108.1
• Coordinates: 102663..103982 (-)
• Length: 440 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: BTK77_RS21740
• Protein ID: WP_080322107.1
• Coordinates: 103985..104266 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BTK77_RS21725 (BTK77_021720)	98045..100576	-	2532	WP_080322110.1	malto-oligosyltrehalose synthase	-
BTK77_RS21730 (BTK77_021725)	100573..102357	-	1785	WP_080322109.1	malto-oligosyltrehalose trehalohydrolase	-
BTK77_RS21735 (BTK77_021730)	102663..103982	-	1320	WP_080322108.1	type II toxin-antitoxin system HipA family toxin	Toxin
BTK77_RS21740 (BTK77_021735)	103985..104266	-	282	WP_080322107.1	helix-turn-helix domain-containing protein	Antitoxin
BTK77_RS21745 (BTK77_021740)	104397..105281	-	885	WP_080322106.1	siderophore-interacting protein	-
BTK77_RS21750 (BTK77_021745)	105278..106489	-	1212	WP_080322105.1	MFS transporter	-
BTK77_RS21755 (BTK77_021750)	106625..108373	+	1749	WP_080322104.1	IucA/IucC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	pla / vipA/tssB / vipB/tssC / mgtB / iucA / iucB / iucC / iutA	1..118185	118185

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (153-404)

Antitoxin

• Cro/C1-type helix-turn-helix domain (21-69)

Sequences

Toxin

Protein

• Length: 440 a.a.
• Molecular weight: 49083.07 Da
• Isoelectric Point: 6.8211

>T209010 WP_080322108.1 NZ_CP078112:c103982-102663 [Cronobacter sakazakii]
MRRTSRLALWMNGIPVGYWDKHNGEDRLTYLPEWIADPQGRPLSLSLPFTPGNQSYRGAQVRDYFDNLLPDSENIRRRLA
MRYRAQSLEPFDLLAELGRDCVGAIQLLPADEAPEGLFTIRARPLSTVDIAAMLRHTAEAFPGQHGGEEELRLSIAGAQE
KTALLWHEGQWCLPEGNTPTTHIFKLPLGLVGNMQADMRTSIENEWLCAQLLAAWDIPVARTQMAQFDEQKVLIVERFDR
RLSADGQWWLRLPQEDMCQVLGVSPLRKYQADGGPGIGDIMTVLSRSENAQADRANFFRAQIIFWILAATDGHAKNFSIA
HLPGNRYHLTPLYDVLSAWPVIGPGNNQIAWQKCKLAMAVRGSSNYYHLSQIRRRHWLRQGELAGLSAAQVNDMIDALTA
SAPAVIARVADALPVDFPASLADVIFNGMRQQCARLAAA

Nucleotide

• Length: 1320 bp

>T209010 NZ_CP103791:840748-841161 [Salmonella enterica subsp. enterica serovar Infantis]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTTCTGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10517.99 Da
• Isoelectric Point: 9.0637

>AT209010 WP_080322107.1 NZ_CP078112:c104266-103985 [Cronobacter sakazakii]
MNTRYPLKTLSQLRPLLVGFRKKQGLTQKEVSARLGVTQQTYARLEANPETASIERLFRVFNVLGIEMTLCETQAAESDA
PARDDSPAHREAW

Nucleotide

• Length: 282 bp

>AT209010 NZ_CP103791:840501-840767 [Salmonella enterica subsp. enterica serovar Infantis]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA