Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3273682..3274345 Replicon chromosome
Accession NZ_CP078110
Organism Cronobacter sakazakii strain MOD1-H322

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag BTK77_RS15510 Protein ID WP_080321076.1
Coordinates 3273682..3274098 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A3Q9CFW7
Locus tag BTK77_RS15515 Protein ID WP_007870701.1
Coordinates 3274079..3274345 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTK77_RS15490 (BTK77_015490) 3269670..3271403 - 1734 WP_080321074.1 single-stranded-DNA-specific exonuclease RecJ -
BTK77_RS15495 (BTK77_015495) 3271407..3272126 - 720 WP_004385678.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
BTK77_RS15500 (BTK77_015500) 3272149..3273045 - 897 WP_105609345.1 site-specific tyrosine recombinase XerD -
BTK77_RS15505 (BTK77_015505) 3273147..3273668 + 522 WP_004385676.1 flavodoxin FldB -
BTK77_RS15510 (BTK77_015510) 3273682..3274098 - 417 WP_080321076.1 protein YgfX Toxin
BTK77_RS15515 (BTK77_015515) 3274079..3274345 - 267 WP_007870701.1 FAD assembly factor SdhE Antitoxin
BTK77_RS15520 (BTK77_015520) 3274623..3275612 + 990 WP_007892600.1 tRNA-modifying protein YgfZ -
BTK77_RS15525 (BTK77_015525) 3275717..3276370 - 654 WP_007777939.1 hemolysin III family protein -
BTK77_RS15530 (BTK77_015530) 3276513..3276827 - 315 WP_080321077.1 N(4)-acetylcytidine aminohydrolase -
BTK77_RS15535 (BTK77_015535) 3277004..3277732 + 729 WP_207559558.1 MurR/RpiR family transcriptional regulator -
BTK77_RS15540 (BTK77_015540) 3277884..3279317 + 1434 WP_080321079.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 16455.47 Da        Isoelectric Point: 11.4887

>T209004 WP_080321076.1 NZ_CP078110:c3274098-3273682 [Cronobacter sakazakii]
VVLWHSDLRVSWRSQWLSLLLHGAVAVIILLLPWPLRYLPVWMLLLSLVVFDCVRSQRRINAFQGEVSLTADYHLRWQGV
DWQICATPWMLRSGMMLRLRHPKTTRRHHVWLAADSMTEAEWRDLRRLLLQQPIGDKR

Download         Length: 417 bp

>T209004 NZ_CP103783:2273053-2273169 [Bacillus subtilis subsp. subtilis str. 168]
ATGACTGTTTACGAATCATTAATGATAATGATCAATTTTGGCGGATTGATATTAAATACCGTCTTGTTGATCTTCAATAT
AATGATGATTGTAACGTCAAGCCAAAAGAAAAAATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10411.89 Da        Isoelectric Point: 4.8310

>AT209004 WP_007870701.1 NZ_CP078110:c3274345-3274079 [Cronobacter sakazakii]
MDINNKARIHWACRRGMRELDISIMPFFEYDYDSLSDEDKRVFVRLLECDDPDLFNWLMNHGKPADAELARMVELIQQRN
QARGPVAL

Download         Length: 267 bp

>AT209004 NZ_CP103783:c2273343-2273164 [Bacillus subtilis subsp. subtilis str. 168]
AATGATACAATTATATAATTATTTTTTGCATTTTGTTTAATTAAATGCATAAAATAAAAAGACCAGGGTGTTGGTAGCAC
CCTGGCTCTGTACAAAAGCTGCCCATCAAAGGGCTTGCTCGTTGTCAAATCTGCGTAGGCCTAACCCTTCAGGTGTCCAA
ACTCAAGGGAAGGTCTATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3Q9CFW7

References