Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2807923..2808662 Replicon chromosome
Accession NZ_CP078110
Organism Cronobacter sakazakii strain MOD1-H322

Toxin (Protein)


Gene name tacT Uniprot ID A0A9E6WPH7
Locus tag BTK77_RS13350 Protein ID WP_013087269.1
Coordinates 2807923..2808408 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A9E6WPN8
Locus tag BTK77_RS13355 Protein ID WP_007869691.1
Coordinates 2808396..2808662 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTK77_RS13330 (BTK77_013330) 2804294..2804491 + 198 WP_004152115.1 hypothetical protein -
BTK77_RS21915 2804729..2804875 + 147 Protein_2604 diguanylate cyclase -
BTK77_RS13335 (BTK77_013335) 2804990..2805478 + 489 WP_004152114.1 phosphate-starvation-inducible PsiE family protein -
BTK77_RS13340 (BTK77_013340) 2805465..2806427 + 963 WP_004152113.1 zinc metalloprotease HtpX -
BTK77_RS13345 (BTK77_013345) 2806604..2807769 + 1166 Protein_2607 IS3 family transposase -
BTK77_RS13350 (BTK77_013350) 2807923..2808408 - 486 WP_013087269.1 GNAT family N-acetyltransferase Toxin
BTK77_RS13355 (BTK77_013355) 2808396..2808662 - 267 WP_007869691.1 DUF1778 domain-containing protein Antitoxin
BTK77_RS13365 (BTK77_013365) 2809588..2809821 + 234 Protein_2611 IS5/IS1182 family transposase -
BTK77_RS13370 (BTK77_013370) 2809863..2810183 - 321 WP_224955247.1 hypothetical protein -
BTK77_RS13375 (BTK77_013375) 2810271..2811512 - 1242 WP_047343499.1 VWA domain-containing protein -
BTK77_RS13380 (BTK77_013380) 2811940..2812515 - 576 WP_020996162.1 TerD family protein -
BTK77_RS13385 (BTK77_013385) 2812584..2813162 - 579 WP_000116680.1 tellurium resistance membrane protein TerD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2791910..2830983 39073
- inside IScluster/Tn - - 2806742..2809821 3079


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-146)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17736.45 Da        Isoelectric Point: 9.5181

>T209003 WP_013087269.1 NZ_CP078110:c2808408-2807923 [Cronobacter sakazakii]
VGRVTAPEPLSSSHQLAEFVSGEAVLDDWLKQRGLKNQALGAARTFVVCKRDTKQVVGFYSLATGSVNHVEAMGSLRRNM
PDPIPVIILARLAVDVSYRGQGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYLHHGFKASQTQERTLFLKLP
Q

Download         Length: 486 bp

>T209003 NZ_CP103783:c2219419-2219243 [Bacillus subtilis subsp. subtilis str. 168]
GTGCTTGAGAAAATGGGTATCGTAGTTGCTTTCCTCATATCTTTAACGGTTCTTACAATCAACAGTCTAACAATAGTTGA
GAAGGTAAGAAACCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTATACGCAAGCGGCTCCGACCAAAGAGACAACGCC
AACGTATACGCCGATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10080.46 Da        Isoelectric Point: 4.3837

>AT209003 WP_007869691.1 NZ_CP078110:c2808662-2808396 [Cronobacter sakazakii]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVSDEAAIDKLL
ARKPQWDV

Download         Length: 267 bp

>AT209003 NZ_CP103783:2219360-2219460 [Bacillus subtilis subsp. subtilis str. 168]
GATTGTAAGAACCGTTAAAGATATGAGGAAAGCAACTACGATACCCATTTTCTCAAGCACTATGTACACCTCCTTTCCTA
TGACTCTATTATAACATAATT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References