Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 959455..960074 Replicon chromosome
Accession NZ_CP078110
Organism Cronobacter sakazakii strain MOD1-H322

Toxin (Protein)


Gene name Hha Uniprot ID A0A2S9UIC9
Locus tag BTK77_RS04595 Protein ID WP_004386909.1
Coordinates 959455..959673 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A3Q9CL77
Locus tag BTK77_RS04600 Protein ID WP_004386908.1
Coordinates 959700..960074 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTK77_RS04570 (BTK77_004570) 955595..957496 + 1902 WP_080321273.1 methyl-accepting chemotaxis protein -
BTK77_RS04575 (BTK77_004575) 957635..957895 + 261 WP_004386912.1 type B 50S ribosomal protein L31 -
BTK77_RS04580 (BTK77_004580) 957899..958039 + 141 WP_004386911.1 type B 50S ribosomal protein L36 -
BTK77_RS04585 (BTK77_004585) 958068..958577 - 510 WP_080321272.1 YlaC family protein -
BTK77_RS04590 (BTK77_004590) 958697..959248 - 552 WP_080321271.1 maltose O-acetyltransferase -
BTK77_RS04595 (BTK77_004595) 959455..959673 - 219 WP_004386909.1 HHA domain-containing protein Toxin
BTK77_RS04600 (BTK77_004600) 959700..960074 - 375 WP_004386908.1 Hha toxicity modulator TomB Antitoxin
BTK77_RS04605 (BTK77_004605) 960537..963686 - 3150 WP_007848020.1 multidrug efflux RND transporter permease subunit AcrB -
BTK77_RS04610 (BTK77_004610) 963708..964913 - 1206 WP_007848022.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8598.02 Da        Isoelectric Point: 9.4828

>T208990 WP_004386909.1 NZ_CP078110:c959673-959455 [Cronobacter sakazakii]
MTTKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTAVWKFVR

Download         Length: 219 bp

>T208990 NZ_CP103771:c4321760-4321392 [Salmonella enterica]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGTCTGATCCTGGGCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATAGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGTGCCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14343.05 Da        Isoelectric Point: 4.7168

>AT208990 WP_004386908.1 NZ_CP078110:c960074-959700 [Cronobacter sakazakii]
MDEYSPKRHDIAQLKFLCESLYHDCLATLGENQHGWVNDPTSAVNLQLNDLIEHIASFGLNYKIKHEDDAALIEQLDEYL
DDTFMLFSNYGINAQDLQKWRKSGNRLFRCFVNASKENPVSLSF

Download         Length: 375 bp

>AT208990 NZ_CP103771:c4321978-4321757 [Salmonella enterica]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGTGCGGTGACGGGGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S9UIC9

Antitoxin

Source ID Structure
AlphaFold DB A0A3Q9CL77

References