Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higB-toxA/Tad-HTH_37
Location 871060..871688 Replicon chromosome
Accession NZ_CP078097
Organism Lacticaseibacillus paracasei subsp. paracasei strain GR0548

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag J5Y16_RS04215 Protein ID WP_003583266.1
Coordinates 871060..871428 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag J5Y16_RS04220 Protein ID WP_003583264.1
Coordinates 871428..871688 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5Y16_RS04195 (J5Y16_04195) 866385..867392 - 1008 WP_003563383.1 LacI family DNA-binding transcriptional regulator -
J5Y16_RS04200 (J5Y16_04200) 867633..867902 + 270 WP_218210092.1 type II toxin-antitoxin system YafQ family toxin -
J5Y16_RS04205 (J5Y16_04205) 868218..869036 + 819 WP_011674103.1 Cof-type HAD-IIB family hydrolase -
J5Y16_RS04210 (J5Y16_04210) 869399..870769 + 1371 WP_003573580.1 FAD-dependent oxidoreductase -
J5Y16_RS04215 (J5Y16_04215) 871060..871428 + 369 WP_003583266.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J5Y16_RS04220 (J5Y16_04220) 871428..871688 + 261 WP_003583264.1 helix-turn-helix transcriptional regulator Antitoxin
J5Y16_RS04225 (J5Y16_04225) 871801..872490 - 690 WP_218210093.1 ABC transporter ATP-binding protein -
J5Y16_RS04230 (J5Y16_04230) 872495..873556 - 1062 WP_218210094.1 ABC transporter permease -
J5Y16_RS04235 (J5Y16_04235) 873561..874064 - 504 WP_003573574.1 TetR/AcrR family transcriptional regulator -
J5Y16_RS04240 (J5Y16_04240) 874260..875045 + 786 WP_126313643.1 hypothetical protein -
J5Y16_RS04245 (J5Y16_04245) 875137..875901 - 765 WP_202665024.1 GH25 family lysozyme -
J5Y16_RS04250 (J5Y16_04250) 875911..876063 - 153 WP_003583252.1 YvrJ family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(34-112)

Antitoxin

Cro/C1-type helix-turn-helix domain

(28-79)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 14939.01 Da        Isoelectric Point: 8.3986

>T208987 WP_003583266.1 NZ_CP078097:871060-871428 [Lacticaseibacillus paracasei subsp. paracasei]
MYKIDFYEDRDGYSEIEDFLDQLRHSHQKNNVSLLNKITKELYMLQNLGPRLREPHAKFLKGYAYPIMELRPMPERIFYA
AWQKDHFVLLHHYTKKTNKTDHREILRAQSNLEDWLSRKEEN

Download         Length: 369 bp

>T208987 NZ_CP103771:c2597658-2597555 [Salmonella enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9828.45 Da        Isoelectric Point: 10.2439

>AT208987 WP_003583264.1 NZ_CP078097:871428-871688 [Lacticaseibacillus paracasei subsp. paracasei]
MTTWEDFSQKLKKDNPEKLAIIKTLADLESERIKQGISQKDFAEKIGMKQPQLAKIERLDSLPTLATLNRYARGLGKEIR
LSIVTQ

Download         Length: 261 bp

>AT208987 NZ_CP103771:2597553-2597696 [Salmonella enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References