Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 2702479..2703062 Replicon chromosome
Accession NZ_CP078096
Organism Geomonas subterranea strain RG3

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag KP002_RS11710 Protein ID WP_217286857.1
Coordinates 2702718..2703062 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag KP002_RS11705 Protein ID WP_217286858.1
Coordinates 2702479..2702721 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KP002_RS11680 (KP002_11680) 2698561..2699385 - 825 WP_217286863.1 A/G-specific adenine glycosylase -
KP002_RS11685 (KP002_11685) 2699633..2699989 + 357 WP_217286862.1 TRL domain-containing protein -
KP002_RS11690 (KP002_11690) 2700123..2700983 + 861 WP_217286861.1 DMT family transporter -
KP002_RS11695 (KP002_11695) 2701124..2701342 + 219 WP_217286860.1 hypothetical protein -
KP002_RS11700 (KP002_11700) 2701470..2702399 + 930 WP_217286859.1 cation diffusion facilitator family transporter -
KP002_RS11705 (KP002_11705) 2702479..2702721 + 243 WP_217286858.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
KP002_RS11710 (KP002_11710) 2702718..2703062 + 345 WP_217286857.1 endoribonuclease MazF Toxin
KP002_RS11715 (KP002_11715) 2703075..2703668 - 594 WP_217286856.1 TetR/AcrR family transcriptional regulator -
KP002_RS11720 (KP002_11720) 2703874..2705436 + 1563 WP_217286855.1 acetyl-CoA hydrolase/transferase C-terminal domain-containing protein -
KP002_RS11725 (KP002_11725) 2705786..2705968 + 183 WP_217286854.1 hypothetical protein -
KP002_RS11730 (KP002_11730) 2706043..2706756 + 714 WP_217286853.1 DUF3108 domain-containing protein -
KP002_RS11735 (KP002_11735) 2706871..2707485 + 615 WP_217286852.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-113)

Antitoxin

SpoVT-AbrB domain

(6-46)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12695.73 Da        Isoelectric Point: 8.5041

>T208984 WP_217286857.1 NZ_CP078096:2702718-2703062 [Geomonas subterranea]
MTVMGYVPDRGEVVWLDFDPQAGHEHAGRRPAFVLSPRSYNKKTSLMLCCPITSQVKGYPFEVAVAGVTTVWGVILADQV
KSLDWQVRRPEKGGRASREVLEEVILKVRAILEG

Download         Length: 345 bp

>T208984 NZ_CP103771:c1213751-1213533 [Salmonella enterica]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8657.99 Da        Isoelectric Point: 5.0506

>AT208984 WP_217286858.1 NZ_CP078096:2702479-2702721 [Geomonas subterranea]
MVAKAQKWGNSLAVRLPKSIAAECGIEADSPVEITRQEGYIIIKPIVNKVFSLDALLDGINEENLHSEVSSGKPVGRELL

Download         Length: 243 bp

>AT208984 NZ_CP103771:c1214153-1213779 [Salmonella enterica]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References