Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1021572..1022065 Replicon chromosome
Accession NZ_CP078094
Organism Enterococcus lactis strain JDM1

Toxin (Protein)


Gene name relE Uniprot ID A0A829A9S0
Locus tag KVG00_RS04865 Protein ID WP_002342567.1
Coordinates 1021799..1022065 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A829AAJ0
Locus tag KVG00_RS04860 Protein ID WP_002329324.1
Coordinates 1021572..1021802 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KVG00_RS04835 (KVG00_04835) 1017043..1017375 + 333 WP_002342563.1 hypothetical protein -
KVG00_RS04840 (KVG00_04840) 1017444..1018606 + 1163 WP_086956687.1 IS3 family transposase -
KVG00_RS04845 (KVG00_04845) 1019027..1019655 - 629 Protein_962 glutamine amidotransferase -
KVG00_RS04850 (KVG00_04850) 1020443..1020748 + 306 WP_002342565.1 hypothetical protein -
KVG00_RS04855 (KVG00_04855) 1020761..1021096 + 336 WP_002329326.1 hypothetical protein -
KVG00_RS04860 (KVG00_04860) 1021572..1021802 + 231 WP_002329324.1 DUF6290 family protein Antitoxin
KVG00_RS04865 (KVG00_04865) 1021799..1022065 + 267 WP_002342567.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KVG00_RS04870 (KVG00_04870) 1022317..1022544 + 228 WP_002329322.1 hypothetical protein -
KVG00_RS04875 (KVG00_04875) 1022560..1023726 + 1167 WP_002329321.1 radical SAM family heme chaperone HemW -
KVG00_RS04880 (KVG00_04880) 1023959..1025002 + 1044 WP_002294449.1 heat-inducible transcriptional repressor HrcA -
KVG00_RS04885 (KVG00_04885) 1025096..1025659 + 564 WP_002292135.1 nucleotide exchange factor GrpE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10651.28 Da        Isoelectric Point: 10.1925

>T208982 WP_002342567.1 NZ_CP078094:1021799-1022065 [Enterococcus lactis]
MTYRLEFTPEIQKQLRKMDKHQATLIVRWLYQHIDGIDDPRKFGKGFTANRSGQWRYRIGKYRVLVEIEDDQMVVIAIQV
GHRRNIYD

Download         Length: 267 bp

>T208982 NZ_CP103771:506274-506582 [Salmonella enterica]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8863.97 Da        Isoelectric Point: 4.1938

>AT208982 WP_002329324.1 NZ_CP078094:1021572-1021802 [Enterococcus lactis]
MAMITVRVSDAEKEWLSYMAEFYGITLSELLKTYSMEQLEDEYDRQTAEIAHKHWVESGKTTVSMEEILHEFGGLE

Download         Length: 231 bp

>AT208982 NZ_CP103771:506032-506271 [Salmonella enterica]
ATGCCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCAGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829A9S0

Antitoxin

Source ID Structure
AlphaFold DB A0A829AAJ0

References