Detailed information of TA system TA208980

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 1662648..1663275
• Replicon: chromosome
• Accession: NZ_CP078093
• Organism: Crassaminicella indica strain 143-21

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: KVH43_RS07880
• Protein ID: WP_218282014.1
• Coordinates: 1662925..1663275 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: KVH43_RS07875
• Protein ID: WP_218282013.1
• Coordinates: 1662648..1662923 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KVH43_RS07850 (KVH43_07850)	1657900..1658505	+	606	WP_218282008.1	hypothetical protein	-
KVH43_RS07855 (KVH43_07855)	1658605..1658970	+	366	WP_255547709.1	holo-ACP synthase	-
KVH43_RS07860 (KVH43_07860)	1659001..1660554	+	1554	WP_218282010.1	NAD(P)H-hydrate dehydratase	-
KVH43_RS07865 (KVH43_07865)	1660622..1661251	+	630	WP_218282011.1	outer-membrane lipoprotein carrier protein LolA	-
KVH43_RS07870 (KVH43_07870)	1661326..1662501	+	1176	WP_218282012.1	alanine racemase	-
KVH43_RS07875 (KVH43_07875)	1662648..1662923	+	276	WP_218282013.1	ribbon-helix-helix protein, CopG family	Antitoxin
KVH43_RS07880 (KVH43_07880)	1662925..1663275	+	351	WP_218282014.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
KVH43_RS07885 (KVH43_07885)	1663746..1666550	+	2805	WP_218282015.1	phosphodiester glycosidase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (2-113)

Antitoxin

• Ribbon-helix-helix protein, CopG (6-43)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12811.80 Da
• Isoelectric Point: 6.4704

>T208980 WP_218282014.1 NZ_CP078093:1662925-1663275 [Crassaminicella indica]
VIVKRGDIFYADLSPVVGSEQGGVRPVLVVQNNIGNKYSPTIIVAAITSQINKAKMPTHVEISASEYGLTKDSVVLLEQV
RTIDKRRLREKIGHSDDEMMDKVNEALLISFGLIDF

Nucleotide

• Length: 351 bp

>T208980 NZ_CP078093:1662925-1663275 [Crassaminicella indica]
GTGATTGTAAAAAGAGGAGATATTTTTTATGCAGATCTTAGTCCTGTTGTTGGTTCCGAACAAGGAGGGGTAAGACCAGT
TCTTGTAGTTCAGAACAACATCGGGAATAAATATAGTCCAACTATCATTGTGGCAGCAATCACCTCACAAATTAACAAAG
CAAAAATGCCTACCCATGTTGAAATTAGTGCTTCGGAATATGGATTAACAAAGGACTCAGTAGTTTTGTTAGAACAAGTT
CGAACTATTGATAAAAGAAGGTTGAGAGAAAAAATAGGGCACTCCGATGATGAGATGATGGATAAGGTGAATGAGGCGTT
ATTAATTAGCTTTGGATTAATAGATTTTTGA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10669.44 Da
• Isoelectric Point: 5.2706

>AT208980 WP_218282013.1 NZ_CP078093:1662648-1662923 [Crassaminicella indica]
MAESKRIMISLPNTLLEEVDNIVAIEKRNRSEFIREAMKLYIRERRKIQIRESMKKGYREMGAMNLTLSEVGLDIDMDVL
SNYEAKLAECE

Nucleotide

• Length: 276 bp

>AT208980 NZ_CP078093:1662648-1662923 [Crassaminicella indica]
ATGGCTGAGTCTAAACGAATTATGATCAGTTTACCAAATACTCTTTTGGAGGAAGTAGATAATATTGTAGCAATAGAGAA
AAGAAATAGAAGTGAATTTATTAGAGAAGCAATGAAATTATATATTCGAGAAAGACGCAAAATTCAAATAAGAGAAAGCA
TGAAAAAGGGTTATAGGGAAATGGGGGCTATGAATTTAACATTATCAGAAGTAGGTTTAGATATAGATATGGATGTATTG
TCAAATTATGAAGCTAAGTTAGCGGAGTGTGAGTAA