Detailed information of TA system TA208979

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2713613..2714241
• Replicon: chromosome
• Accession: NZ_CP078092
• Organism: Geobacter sulfurreducens strain PCA_v2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q74AB8
• Locus tag: KVP06_RS12430
• Protein ID: WP_010943110.1
• Coordinates: 2713613..2714014 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: Q74AB7
• Locus tag: KVP06_RS12435
• Protein ID: WP_010943111.1
• Coordinates: 2714014..2714241 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KVP06_RS12405 (KVP06_12400)	2709411..2709761	+	351	WP_010943106.1	hypothetical protein	-
KVP06_RS12410 (KVP06_12405)	2709914..2710441	+	528	WP_010943107.1	hypothetical protein	-
KVP06_RS12415 (KVP06_12410)	2710465..2711220	+	756	WP_010943108.1	hypothetical protein	-
KVP06_RS12420 (KVP06_12415)	2711258..2711647	+	390	WP_010943109.1	hypothetical protein	-
KVP06_RS12425 (KVP06_12420)	2711725..2713065	-	1341	WP_164930422.1	group II intron reverse transcriptase/maturase	-
KVP06_RS12430 (KVP06_12425)	2713613..2714014	-	402	WP_010943110.1	type II toxin-antitoxin system VapC family toxin	Toxin
KVP06_RS12435 (KVP06_12430)	2714014..2714241	-	228	WP_010943111.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
KVP06_RS12440 (KVP06_12435)	2714825..2717635	+	2811	WP_010943112.1	GPMC system transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-123)

Antitoxin

• SpoVT-AbrB domain (7-53)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14702.12 Da
• Isoelectric Point: 4.8615

>T208979 WP_010943110.1 NZ_CP078092:c2714014-2713613 [Geobacter sulfurreducens]
MKLLLDTNICIYIIKQQPVAVLERFLEYQVGDIGISSITLSELRYGVAKSTHMEKNAKALDEFIIPLELVSYDESAAHVY
GDIRAALEKAGTPIGSMDMLIAAHAVSLGIPLVTNNTREFLRVPSLNIIDWTV

Nucleotide

• Length: 402 bp

>T208979 NZ_CP103770:c1242126-1241380 [Bacillus velezensis]
ATGCTTTTGTTTTTTCAGATCATGGTGTGGACGATGGCGGCCGCACTCATTTTATATGTGTACGCATCCTGGCGGTATGA
GGCAAAGGTGAAAGAAAAAATGTTTGCCATCCGTAAAACGTGGTATTTACTATTTGTACTGGGCTCCATGGTCTATTGGA
CATATGATCCTGAATCGCTCTTTGCCGCATGGAGACAATATTTGATTGTTGCCGTCTGCTTTGCCCTTATTGATGCGTTT
ATCTTTTTGAGCGCGTATATCAAAAAGCTCGCCGGCAATGAATTAGAGACGGATACGCGGGAAATTTTAGAAGAAAATAA
CGAAATGCTTCACTCCTATCTTGAAAAACTGAAAACCTATCAATATCTGTTGAAAAATGAACCGATCCATGTATATTATG
GAAGTACAGAAGCTTATGCGGAAGGCATCAGCAGACTGCTGGCCGCTTATGCCGAAAAAATGAATGTCACGGCTTCCTTG
TGCGACTATTCCGCACAATCGGATAAGGACCGCTTGACGGAGCATATGCCTGATGCGGCAGACGTTCAGTCCCGTCTTAA
CCGTAAAGACGTCTACTATGATCAAAAAGGCAGGCTTGTGCTTATTCCGTTTACAGTCCAGAACCGCCATTACGTGATCA
AACTCACGTCGGAAAACCTGTTGACGGAATTCGATTATTTGCTTTTCACATCGCTAACGAGCATTTATGATTTAATGCTG
CCAATAGAAGAGGAAGGTGACGGTTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8772.02 Da
• Isoelectric Point: 10.5623

>AT208979 WP_010943111.1 NZ_CP078092:c2714241-2714014 [Geobacter sulfurreducens]
MKTAKIFQNGQSQAVRLPKEFRFEDSEVFIKKSGNVVQLIPRSDSWNSLFGSLKKFSRDFMSERIQPELDKRDGF

Nucleotide

• Length: 228 bp

>AT208979 NZ_CP103770:c1241379-1241209 [Bacillus velezensis]
ATGGAGCAGGCATTTCAAAACGGGCAGCCGGAACAAAGAGCGAAACCGTTCAAAATGTTTAAAAAACGTTCAATGACAAG
TATCGCAAGTTACCAGGTCAGCCCTCATACCGCCAGAATTTTCAAAGAAAACGAGCGGCTGATTGACAAGTATAAACAAA
AAAAAGCTTGA

Structures

Toxin

• AlphaFold DB: Q74AB8

Antitoxin

• AlphaFold DB: Q74AB7