Detailed information of TA system TA208978

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 2676462..2676987
• Replicon: chromosome
• Accession: NZ_CP078092
• Organism: Geobacter sulfurreducens strain PCA_v2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q74AD7
• Locus tag: KVP06_RS12265
• Protein ID: WP_010943076.1
• Coordinates: 2676697..2676987 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q74AD8
• Locus tag: KVP06_RS12260
• Protein ID: WP_010943075.1
• Coordinates: 2676462..2676707 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KVP06_RS12240 (KVP06_12235)	2672563..2673270	-	708	WP_010943071.1	lipoyl(octanoyl) transferase LipB	-
KVP06_RS12245 (KVP06_12240)	2673300..2674556	-	1257	WP_010943072.1	dihydrolipoamide acetyltransferase family protein	-
KVP06_RS12250 (KVP06_12245)	2674572..2675558	-	987	WP_010943073.1	alpha-ketoacid dehydrogenase subunit beta	-
KVP06_RS12255 (KVP06_12250)	2675599..2676084	-	486	WP_010943074.1	VOC family protein	-
KVP06_RS12260 (KVP06_12255)	2676462..2676707	+	246	WP_010943075.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
KVP06_RS12265 (KVP06_12260)	2676697..2676987	+	291	WP_010943076.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KVP06_RS12270 (KVP06_12265)	2677036..2677452	-	417	WP_010943077.1	hypothetical protein	-
KVP06_RS12275 (KVP06_12270)	2677580..2678326	-	747	WP_010943078.1	class I SAM-dependent methyltransferase	-
KVP06_RS12280 (KVP06_12275)	2678551..2679573	-	1023	WP_010943079.1	RelA/SpoT domain-containing protein	-
KVP06_RS12285 (KVP06_12280)	2680330..2681307	-	978	WP_010943082.1	pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-67)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11331.30 Da
• Isoelectric Point: 10.4995

>T208978 WP_010943076.1 NZ_CP078092:2676697-2676987 [Geobacter sulfurreducens]
MSYSLEFKESALKEWKKLDGRIREQFKKKLTERLELPRVEPARLSGMPDCYKIKLKNAGYRLVYQVDDNRIIVTVVAVGK
RENLTVYRAAEKRVKQ

Nucleotide

• Length: 291 bp

>T208978 NZ_CP103770:490235-490585 [Bacillus velezensis]
TTGATTGTAAAGCGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGCGTACGCCCGGT
TTTAGTGATCCAAAATGATATCGGAAATCGCTTTAGCCCGACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGATTAACGGATAAAATAACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
GCAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9193.46 Da
• Isoelectric Point: 4.6631

>AT208978 WP_010943075.1 NZ_CP078092:2676462-2676707 [Geobacter sulfurreducens]
MERLFARASVSISDLKKNPTRIINQSEGEPVAILNHNKPSAYLIPADAFEALMEKLEDYELSQIVKEREHEPSVKVSLDE
L

Nucleotide

• Length: 246 bp

>AT208978 NZ_CP103770:489948-490229 [Bacillus velezensis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCTGAAAACTTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGGACAACTCGCCATAACC
GTGATTTGATGAGACGCGGGTATATGGAAATGGCGAAAATCAACTTGAATATCTCTTCTGAGGCTCACTATGCTGAGTGC
GAAGCAGAAACGACCGTTGAGCGCTTAGTCAGCGGAGGATAA

Structures

Toxin

• AlphaFold DB: Q74AD7

Antitoxin

• AlphaFold DB: Q74AD8