Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 1289057..1290283 Replicon chromosome
Accession NZ_CP078071
Organism Burkholderia sp. EMB26

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KU887_RS22610 Protein ID WP_112751221.1
Coordinates 1289702..1290283 (+) Length 194 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KU887_RS22605 Protein ID WP_058903402.1
Coordinates 1289057..1289623 (+) Length 189 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU887_RS22580 (KU887_22470) 1284450..1285085 + 636 WP_059721935.1 isochorismatase family cysteine hydrolase -
KU887_RS22585 (KU887_22475) 1285111..1285842 - 732 WP_006498851.1 ribonuclease T2 -
KU887_RS22590 (KU887_22480) 1285878..1286462 + 585 WP_258258204.1 OsmC family protein -
KU887_RS22595 (KU887_22485) 1286541..1287113 - 573 WP_205671874.1 hypothetical protein -
KU887_RS22600 (KU887_22490) 1287207..1288610 - 1404 WP_058903401.1 hypothetical protein -
KU887_RS22605 (KU887_22495) 1289057..1289623 + 567 WP_058903402.1 helix-turn-helix transcriptional regulator Antitoxin
KU887_RS22610 (KU887_22500) 1289702..1290283 + 582 WP_112751221.1 HD domain-containing protein Toxin
KU887_RS22615 (KU887_22505) 1290339..1291067 + 729 WP_109342739.1 class I SAM-dependent methyltransferase -
KU887_RS22620 (KU887_22510) 1291339..1292532 + 1194 WP_059722066.1 efflux RND transporter periplasmic adaptor subunit -
KU887_RS22625 (KU887_22515) 1292535..1294568 + 2034 WP_048986896.1 MacB family efflux pump subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-173)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 194 a.a.        Molecular weight: 21310.91 Da        Isoelectric Point: 4.9572

>T208971 WP_112751221.1 NZ_CP078071:1289702-1290283 [Burkholderia sp. EMB26]
MNPDTIRARLDFLRDAERLKDVLRSGHTSAGRAESTAEHSWRLCLMALVFADALPGVDTLKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSAHERDDLLTLTASLDRAVRDEIVALWDEYEAAASPEARAAKALDKLETILQHNQGSNPPDFDYAFNLGY
GRRYTDAAPLFSAIREIVDVDTQRRIDAGGQRA

Download         Length: 582 bp

>T208971 NZ_CP103763:126690-127070 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGCAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTAGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin


Download         Length: 189 a.a.        Molecular weight: 20617.58 Da        Isoelectric Point: 10.7753

>AT208971 WP_058903402.1 NZ_CP078071:1289057-1289623 [Burkholderia sp. EMB26]
MPHPPLHPSSLGPQLKRWRALHRVKQSHAAELFRVAQSTISRWEAGLQQMSPAERATAERLLAARLDSAGDHALARLIAG
STGRMHLVCDFTHRLLASSPARAAEFSRPLSTLLGASLWRYATPEIARMEAALDPLGWYDRAGPPSVEFDTGANASRVVP
IRGSLCRWTRMTLSDGSAVRLVETLDAH

Download         Length: 567 bp

>AT208971 NZ_CP103763:126469-126690 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAGGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References