Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
| Location | 963861..965653 | Replicon | chromosome |
| Accession | NZ_CP078071 | ||
| Organism | Burkholderia sp. EMB26 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | A0A364H4T8 |
| Locus tag | KU887_RS21150 | Protein ID | WP_006496927.1 |
| Coordinates | 964757..965653 (-) | Length | 299 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | A0A364H4C6 |
| Locus tag | KU887_RS21145 | Protein ID | WP_006496928.1 |
| Coordinates | 963861..964718 (-) | Length | 286 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KU887_RS21125 (KU887_21035) | 959024..960514 | - | 1491 | WP_006487205.1 | aldehyde dehydrogenase | - |
| KU887_RS21130 (KU887_21040) | 960587..961414 | - | 828 | WP_034202181.1 | aspartate dehydrogenase | - |
| KU887_RS21135 (KU887_21045) | 961407..963074 | - | 1668 | WP_006496930.1 | thiamine pyrophosphate-binding protein | - |
| KU887_RS21140 (KU887_21050) | 963067..963864 | - | 798 | WP_006496929.1 | SDR family oxidoreductase | - |
| KU887_RS21145 (KU887_21055) | 963861..964718 | - | 858 | WP_006496928.1 | IclR family transcriptional regulator | Antitoxin |
| KU887_RS21150 (KU887_21060) | 964757..965653 | - | 897 | WP_006496927.1 | alpha/beta fold hydrolase | Toxin |
| KU887_RS21155 (KU887_21065) | 965672..966199 | - | 528 | WP_006489904.1 | cupin domain-containing protein | - |
| KU887_RS21160 (KU887_21070) | 966234..967004 | - | 771 | WP_212157692.1 | SDR family oxidoreductase | - |
| KU887_RS21165 (KU887_21075) | 966997..968067 | - | 1071 | WP_006489909.1 | aromatic ring-hydroxylating dioxygenase subunit alpha | - |
| KU887_RS21170 (KU887_21080) | 968120..968431 | - | 312 | WP_006489911.1 | hypothetical protein | - |
| KU887_RS21175 (KU887_21085) | 968433..968750 | - | 318 | WP_006489883.1 | non-heme iron oxygenase ferredoxin subunit | - |
| KU887_RS21180 (KU887_21090) | 969195..970274 | + | 1080 | WP_006489902.1 | porin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 299 a.a. Molecular weight: 30543.75 Da Isoelectric Point: 7.7324
>T208970 WP_006496927.1 NZ_CP078071:c965653-964757 [Burkholderia sp. EMB26]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAQHAGRALPVVLLHGIGSGAASWVRQLDTLGASRRVLAW
DAPGYGVSTPVHGASPAAADYAAALNAWLEALGIERCVLVGHSLGAIIAGGLARVTPARIAGLLLVSPAGGYGSAPAETR
EARRDARLAMLAELGPAGLAEQRSGNMLSGFANEEAKAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAAYSALIDSFCRQCDTQWGLA
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAQHAGRALPVVLLHGIGSGAASWVRQLDTLGASRRVLAW
DAPGYGVSTPVHGASPAAADYAAALNAWLEALGIERCVLVGHSLGAIIAGGLARVTPARIAGLLLVSPAGGYGSAPAETR
EARRDARLAMLAELGPAGLAEQRSGNMLSGFANEEAKAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAAYSALIDSFCRQCDTQWGLA
Download Length: 897 bp
>T208970 NZ_CP103763:114064-114480 [Escherichia coli]
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAGCCGTCCTGAAGCGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTAACGAATAATACAAGAGAATTTGAGCGAGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAGCCGTCCTGAAGCGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTAACGAATAATACAAGAGAATTTGAGCGAGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA
Antitoxin
Download Length: 286 a.a. Molecular weight: 31371.86 Da Isoelectric Point: 6.5061
>AT208970 WP_006496928.1 NZ_CP078071:c964718-963861 [Burkholderia sp. EMB26]
MSEPLQQNESENAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGVLNRMTSATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQKIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR
MSEPLQQNESENAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGVLNRMTSATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQKIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR
Download Length: 858 bp
>AT208970 NZ_CP103763:113837-114067 [Escherichia coli]
ATGAGAACCGTATCGATATTTAAAAATGGCAACAACCGCGCCATCCGTCTGCCTCGTGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCAACCTGGGGATCATTCCTAGAGTACG
AAAAAGCCGATCCAGATTTTATGGCGGAGCGCGAGGATGTTGTCAGCGACGAAGGGCGATTTAACCTGTGA
ATGAGAACCGTATCGATATTTAAAAATGGCAACAACCGCGCCATCCGTCTGCCTCGTGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCAACCTGGGGATCATTCCTAGAGTACG
AAAAAGCCGATCCAGATTTTATGGCGGAGCGCGAGGATGTTGTCAGCGACGAAGGGCGATTTAACCTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A364H4T8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A364H4C6 |