Detailed information of TA system TA208969

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 160835..161481
• Replicon: chromosome
• Accession: NZ_CP078071
• Organism: Burkholderia sp. EMB26

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: KU887_RS17475
• Protein ID: WP_258256906.1
• Coordinates: 161074..161481 (+)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: B4EGU8
• Locus tag: KU887_RS17470
• Protein ID: WP_006491146.1
• Coordinates: 160835..161077 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU887_RS17455 (KU887_17400)	156829..158235	+	1407	WP_034202505.1	aspartate ammonia-lyase	-
KU887_RS17460 (KU887_17405)	158314..159819	+	1506	WP_258256899.1	amino acid permease	-
KU887_RS17465 (KU887_17410)	159893..160576	-	684	WP_253566834.1	phospholipase	-
KU887_RS17470 (KU887_17415)	160835..161077	+	243	WP_006491146.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
KU887_RS17475 (KU887_17420)	161074..161481	+	408	WP_258256906.1	type II toxin-antitoxin system VapC family toxin	Toxin
KU887_RS17480 (KU887_17425)	161882..164257	+	2376	WP_258256907.1	MCP four helix bundle domain-containing protein	-
KU887_RS17485	164661..165008	+	348	WP_226273020.1	methyl-accepting chemotaxis protein	-
KU887_RS17490 (KU887_17435)	165005..165586	+	582	WP_058902967.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-122)

Antitoxin

• SpoVT-AbrB domain (7-49)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 14831.94 Da
• Isoelectric Point: 6.3755

>T208969 WP_258256906.1 NZ_CP078071:161074-161481 [Burkholderia sp. EMB26]
MKFLLDTNAVIAILKGEPAILARLHAWHPADFGIPAIVAHALYYGAYKSQRAAANVARVEALQFEVVSFDTEDAQHAGEI
RAHLIAAGTPIGPYDALIAGQARARHLVLVTHNVREFERVPRLQFEDWLAEPSAD

Nucleotide

• Length: 408 bp

>T208969 NZ_CP103763:c107663-107358 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8849.02 Da
• Isoelectric Point: 5.0197

>AT208969 WP_006491146.1 NZ_CP078071:160835-161077 [Burkholderia sp. EMB26]
MDTAKLFKHGGSQAVRLPKDFRFDTAEVRIRRHGAAVILEPMPQDWAWLAPLIGPVDADFEAAATTQPSAQERSGLDVFE

Nucleotide

• Length: 243 bp

>AT208969 NZ_CP103763:c107883-107665 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATACAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA

Structures

Antitoxin

• AlphaFold DB: B4EGU8