Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 1860985..1861519 Replicon chromosome
Accession NZ_CP078070
Organism Burkholderia sp. EMB26

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag KU887_RS08740 Protein ID WP_021033200.1
Coordinates 1861220..1861519 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag KU887_RS08735 Protein ID WP_021033199.1
Coordinates 1860985..1861230 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU887_RS08720 (KU887_08705) 1857694..1858533 + 840 WP_058902265.1 N(5)-hydroxyornithine transformylase PvdF -
KU887_RS08725 (KU887_08710) 1858533..1859549 + 1017 WP_034201946.1 GNAT family N-acetyltransferase -
KU887_RS08730 (KU887_08715) 1859707..1860870 + 1164 WP_006486051.1 M20 aminoacylase family protein -
KU887_RS08735 (KU887_08720) 1860985..1861230 + 246 WP_021033199.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
KU887_RS08740 (KU887_08725) 1861220..1861519 + 300 WP_021033200.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KU887_RS08745 (KU887_08730) 1861610..1862914 - 1305 WP_058901452.1 cobyrinate a,c-diamide synthase -
KU887_RS08750 (KU887_08735) 1862917..1863519 - 603 WP_006476035.1 cob(I)yrinic acid a,c-diamide adenosyltransferase -
KU887_RS08755 (KU887_08740) 1863555..1863932 - 378 WP_006496449.1 cobalamin biosynthesis protein -
KU887_RS08760 (KU887_08745) 1863929..1864678 - 750 WP_034201945.1 uroporphyrinogen-III C-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-94)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11720.37 Da        Isoelectric Point: 6.9677

>T208968 WP_021033200.1 NZ_CP078070:1861220-1861519 [Burkholderia sp. EMB26]
MAVKGRQLRLTPLAECDLEDIWRYTAEHWSPEQAEHYYRDLIGTMEALARGKKAGRICVVRDGYFRYPAGSHVVFYRETD
ETIDVIRVLHQRMDIERHL

Download         Length: 300 bp

>T208968 NZ_CP103763:c38490-38356 [Escherichia coli]
ATGACGAAATATACCCTTATCGGGTTGCTTGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACAGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8708.68 Da        Isoelectric Point: 7.3196

>AT208968 WP_021033199.1 NZ_CP078070:1860985-1861230 [Burkholderia sp. EMB26]
MSRNTSVSLGDHFAEFVDAQVRSGRYGSASDVVRAGLRLLESHETQMRALQEALKAGEGSGTPKPFDSEAFLARMRATHG
G

Download         Length: 246 bp

>AT208968 NZ_CP103763:38535-38595 [Escherichia coli]
TAAAGTGCATCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References