Detailed information of TA system TA208967

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-vagC/VapC-VagC
• Location: 166002..166639
• Replicon: chromosome
• Accession: NZ_CP078070
• Organism: Burkholderia sp. EMB26

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: KU887_RS00755
• Protein ID: WP_058902008.1
• Coordinates: 166238..166639 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: A0A364GPY9
• Locus tag: KU887_RS00750
• Protein ID: WP_034201144.1
• Coordinates: 166002..166238 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU887_RS00730 (KU887_00725)	161363..162379	+	1017	WP_258251956.1	helix-turn-helix domain-containing protein	-
KU887_RS00735 (KU887_00730)	162489..163586	-	1098	WP_258251958.1	ADP-heptose--LPS heptosyltransferase	-
KU887_RS00740 (KU887_00735)	163583..165286	-	1704	WP_059721116.1	thiamine pyrophosphate-binding protein	-
KU887_RS00745 (KU887_00740)	165655..165884	+	230	Protein_144	type II toxin-antitoxin system RelE/ParE family toxin	-
KU887_RS00750 (KU887_00745)	166002..166238	+	237	WP_034201144.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
KU887_RS00755 (KU887_00750)	166238..166639	+	402	WP_058902008.1	type II toxin-antitoxin system VapC family toxin	Toxin
KU887_RS00760 (KU887_00755)	166706..168094	-	1389	WP_006485681.1	L-serine ammonia-lyase	-
KU887_RS00765 (KU887_00760)	168125..169255	-	1131	WP_230391081.1	alginate lyase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-120)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 15043.22 Da
• Isoelectric Point: 5.6634

>T208967 WP_058902008.1 NZ_CP078070:166238-166639 [Burkholderia sp. EMB26]
MPRFMLDTNMCIYLMKNQPEQVARRFAQCYTGDVVMSAITYAELEYGLTACANPARERRHLAALIEDIPVAPFDAAAAQA
YGPVREATRERKKDHLDKLIAAHAVSLDVVLVTNNERDFVSYPGLRLENWLND

Nucleotide

• Length: 402 bp

>T208967 NZ_CP103762:c4912806-4912495 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8982.15 Da
• Isoelectric Point: 6.4701

>AT208967 WP_034201144.1 NZ_CP078070:166002-166238 [Burkholderia sp. EMB26]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERVGDEIRIRPMRRPLTQVLAKFAKFGPDFMADGRGDHEQAEREGL

Nucleotide

• Length: 237 bp

>AT208967 NZ_CP103762:c4912494-4912204 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACACCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGAAC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACTGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAGGCACTTAACCGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A364GPY9