Detailed information of TA system TA208966

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 2984597..2985195
• Replicon: chromosome
• Accession: NZ_CP078069
• Organism: Comamonas sp. NLF-1-9

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: KUD94_RS14415
• Protein ID: WP_218237853.1
• Coordinates: 2984597..2984854 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: KUD94_RS14420
• Protein ID: WP_255568869.1
• Coordinates: 2984851..2985195 (+)
• Length: 115 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KUD94_RS14405 (KUD94_14405)	2979913..2981520	+	1608	WP_218237851.1	hypothetical protein	-
KUD94_RS14410 (KUD94_14410)	2981635..2984538	+	2904	WP_218237852.1	class I SAM-dependent DNA methyltransferase	-
KUD94_RS14415 (KUD94_14415)	2984597..2984854	+	258	WP_218237853.1	type II toxin-antitoxin system HicA family toxin	Toxin
KUD94_RS14420 (KUD94_14420)	2984851..2985195	+	345	WP_255568869.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
KUD94_RS14425 (KUD94_14425)	2985399..2985632	+	234	WP_218237854.1	addiction module protein	-
KUD94_RS14430 (KUD94_14430)	2985598..2985912	+	315	WP_255568872.1	type II toxin-antitoxin system RelE/ParE family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (25-74)

Antitoxin

• Uncharacterised protein family HicB (57-107)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9402.92 Da
• Isoelectric Point: 10.5974

>T208966 WP_218237853.1 NZ_CP078069:2984597-2984854 [Comamonas sp. NLF-1-9]
MKRKHAKTLELLFHRPVSANVAHADVMALLQELGAQIETSREGSRVAVVLFGQVRVLHKPHPSPHMDKGAVAALRDWLEH
NGVTP

Nucleotide

• Length: 258 bp

>T208966 NZ_CP103762:c4631625-4631452 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 115 a.a.
• Molecular weight: 12496.13 Da
• Isoelectric Point: 6.8704

>AT208966 WP_255568869.1 NZ_CP078069:2984851-2985195 [Comamonas sp. NLF-1-9]
MSTMNTMELDGYTAVIQYNPETDAFRGEVQGINGGADFYGKTPEELRREFRASLDFFLQTCAKHGIAPRKAASGKFMVRL
PQALHEQAATVAAAHGISLNALVERALRHEVQSA

Nucleotide

• Length: 345 bp

>AT208966 NZ_CP103762:c4631949-4631653 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCATTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG