Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 1631510..1632563 Replicon chromosome
Accession NZ_CP078069
Organism Comamonas sp. NLF-1-9

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag KUD94_RS07905 Protein ID WP_255568657.1
Coordinates 1631976..1632563 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag KUD94_RS07900 Protein ID WP_218236433.1
Coordinates 1631510..1631971 (+) Length 154 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KUD94_RS07885 (KUD94_07885) 1626640..1628718 + 2079 WP_218236427.1 RecQ family ATP-dependent DNA helicase -
KUD94_RS07890 (KUD94_07890) 1628715..1630103 + 1389 WP_218236429.1 DNA-processing protein DprA -
KUD94_RS07895 (KUD94_07895) 1630188..1631237 + 1050 WP_218236431.1 IS30 family transposase -
KUD94_RS07900 (KUD94_07900) 1631510..1631971 + 462 WP_218236433.1 helix-turn-helix domain-containing protein Antitoxin
KUD94_RS07905 (KUD94_07905) 1631976..1632563 + 588 WP_255568657.1 PIN domain-containing protein Toxin
KUD94_RS07910 (KUD94_07910) 1632461..1633342 + 882 WP_255568659.1 recombinase family protein -
KUD94_RS07915 (KUD94_07915) 1633342..1633713 + 372 WP_218236435.1 site-specific recombinase resolvase -
KUD94_RS07920 (KUD94_07920) 1633710..1634174 + 465 WP_218236436.1 hypothetical protein -
KUD94_RS07925 (KUD94_07925) 1634229..1634903 + 675 WP_218236438.1 SOS response-associated peptidase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-114)

Antitoxin

SinI-like, DNA-binding domain

(83-129)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21821.88 Da        Isoelectric Point: 7.7234

>T208964 WP_255568657.1 NZ_CP078069:1631976-1632563 [Comamonas sp. NLF-1-9]
MSSHFTVVYDACVLYPAPLRDLLMHLALSDLYRARWSDMLHDEWTRNVLASRPDLTQEQLNRTRQLMNAHVRDSLVTGFE
YLIPSIKLPDPDDRHVVAAAIHSGASLIVTFNLKDFPFDALKPCNLAAQHPDDFIVDLLDLHPAPASASATRSPPANAKG
CGWAAYHPWATTSRTACWSSTKPRLRWCGASSRRC

Download         Length: 588 bp

>T208964 NZ_CP103762:c4459357-4459007 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 154 a.a.        Molecular weight: 17044.56 Da        Isoelectric Point: 6.7336

>AT208964 WP_218236433.1 NZ_CP078069:1631510-1631971 [Comamonas sp. NLF-1-9]
MNAPAIPKTLPSEEDIALARESGRALSTVLQTRAETQQIDFHDEKGTVRAVRIPTSALRLLLEVLTEIGQGNAVSIIPIH
AELTTQEAADVLNVSRPFLVQLLEKGDIPFYKIGTHRRVRYQDVIAYKKRIDAERRKALDELAVQGQELGMGY

Download         Length: 462 bp

>AT208964 NZ_CP103762:c4459602-4459351 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References