Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 255000..255608 Replicon chromosome
Accession NZ_CP078069
Organism Comamonas sp. NLF-1-9

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag KUD94_RS01170 Protein ID WP_218238095.1
Coordinates 255000..255290 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag KUD94_RS01175 Protein ID WP_218238096.1
Coordinates 255306..255608 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KUD94_RS01145 (KUD94_01145) 250702..251421 + 720 WP_218238090.1 YebC/PmpR family DNA-binding transcriptional regulator -
KUD94_RS01150 (KUD94_01150) 251449..252723 + 1275 WP_218238091.1 phosphoribosylamine--glycine ligase -
KUD94_RS01155 (KUD94_01155) 252720..253658 + 939 WP_218238092.1 oxygen-dependent coproporphyrinogen oxidase -
KUD94_RS01160 (KUD94_01160) 253759..254436 + 678 WP_218238093.1 ribosome silencing factor -
KUD94_RS01165 (KUD94_01165) 254449..254916 + 468 WP_218238094.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
KUD94_RS01170 (KUD94_01170) 255000..255290 + 291 WP_218238095.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KUD94_RS01175 (KUD94_01175) 255306..255608 + 303 WP_218238096.1 putative addiction module antidote protein Antitoxin
KUD94_RS01180 (KUD94_01180) 255753..256694 - 942 WP_218238097.1 hypothetical protein -
KUD94_RS01185 (KUD94_01185) 256691..257299 - 609 WP_218238098.1 hypothetical protein -
KUD94_RS01190 (KUD94_01190) 257464..258291 - 828 WP_218239150.1 ABC transporter permease -
KUD94_RS01195 (KUD94_01195) 258297..259109 - 813 WP_218238099.1 ABC transporter ATP-binding protein -
KUD94_RS01200 (KUD94_01200) 259116..260141 - 1026 WP_218238100.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(48-92)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10857.37 Da        Isoelectric Point: 8.0668

>T208959 WP_218238095.1 NZ_CP078069:255000-255290 [Comamonas sp. NLF-1-9]
MLVIHTTETFDRWFESLRDRRAAQRIQARIDRAEDGNFGDCEPIGEGVSEMRIHHGPGYRVYFVGRGMEVVILLAGGNKA
SQGKDIKTALELARRL

Download         Length: 291 bp

>T208959 NZ_CP103762:3733841-3734059 [Escherichia coli]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10817.45 Da        Isoelectric Point: 5.7121

>AT208959 WP_218238096.1 NZ_CP078069:255306-255608 [Comamonas sp. NLF-1-9]
MEPLKLRRWDSAEHLKTEEDMVLYLQACMEEAGDDAAFIAKALGNVARARGMTQLAKETGLGRESLYKALSGEGNPSFGT
ILKVMHALGIKLQAQAADPA

Download         Length: 303 bp

>AT208959 NZ_CP103762:3733441-3733815 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References