208953

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 32876..33404 Replicon plasmid pAJ_068-2
Accession NZ_CP078043
Organism Acinetobacter junii strain AJ_068

Toxin (Protein)


Gene name relE Uniprot ID N8SCV7
Locus tag EGT68_RS15365 Protein ID WP_004733298.1
Coordinates 33111..33404 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1E8DZ10
Locus tag EGT68_RS15360 Protein ID WP_026438268.1
Coordinates 32876..33121 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGT68_RS15340 (EGT68_015340) 28006..29664 - 1659 WP_005006360.1 ThiF family adenylyltransferase -
EGT68_RS15345 (EGT68_015345) 29674..30687 - 1014 WP_005006358.1 nucleotidyltransferase -
EGT68_RS15350 (EGT68_015350) 31418..31984 + 567 WP_125272790.1 recombinase family protein -
EGT68_RS16740 32193..32327 - 135 Protein_29 cysteine hydrolase -
EGT68_RS15355 (EGT68_015355) 32446..32781 + 336 WP_055414483.1 hypothetical protein -
EGT68_RS15360 (EGT68_015360) 32876..33121 + 246 WP_026438268.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EGT68_RS15365 (EGT68_015365) 33111..33404 + 294 WP_004733298.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EGT68_RS15370 (EGT68_015370) 33470..33784 - 315 WP_005108843.1 hypothetical protein -
EGT68_RS15375 (EGT68_015375) 33891..34322 + 432 WP_018680121.1 hypothetical protein -
EGT68_RS15380 (EGT68_015380) 34312..34638 + 327 WP_005108845.1 hypothetical protein -
EGT68_RS15385 (EGT68_015385) 34847..35215 - 369 Protein_36 IS1-like element ISAba3 family transposase -
EGT68_RS15390 (EGT68_015390) 35296..36138 + 843 WP_002002480.1 carbapenem-hydrolyzing class D beta-lactamase OXA-58 -
EGT68_RS15395 (EGT68_015395) 36229..36935 + 707 Protein_38 IS1 family transposase -
EGT68_RS15400 (EGT68_015400) 37068..38393 - 1326 WP_020846983.1 ISNCY family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn blaOXA-58 / msr(E) / mph(E) / aph(6)-Id / aac(3)-IId - 34769..57366 22597
- inside Non-Mobilizable plasmid blaOXA-58 / msr(E) / mph(E) / aph(6)-Id / aac(3)-IId / aph(3')-VIa / sul1 / qacE / ARR-3 / aph(3')-VI / blaNDM-1 / sul2 / aph(3'')-Ib / floR - 1..264416 264416


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-74)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11252.46 Da        Isoelectric Point: 10.4456

>T208953 WP_004733298.1 NZ_CP078043:33111-33404 [Acinetobacter junii]
MTYKLLRHKDFTAEWEKLPSAIRDQFKKKLAKVIEQPHIPKNMLKGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD

Download         Length: 294 bp

>T208953 NZ_CP103762:2435623-2435910 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9248.61 Da        Isoelectric Point: 4.2821

>AT208953 WP_026438268.1 NZ_CP078043:32876-33121 [Acinetobacter junii]
MATVNFRVDEALKEKSYSILKEQGIAPTEFFTNILEYIATTGKLPVQKALLSEEDTELLAIVRKRVNDPKEMFEEVTLDD
L

Download         Length: 246 bp

>AT208953 NZ_CP103762:2435384-2435623 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB N8SCV7

Antitoxin

Source ID Structure
AlphaFold DB A0A1E8DZ10

References