Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1610652..1612288 Replicon chromosome
Accession NZ_CP078042
Organism Acinetobacter junii strain AJ_068

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag EGT68_RS07810 Protein ID WP_087540912.1
Coordinates 1610652..1611983 (+) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag EGT68_RS07815 Protein ID WP_087540911.1
Coordinates 1611980..1612288 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGT68_RS07785 (EGT68_007785) 1606049..1607044 + 996 WP_004911105.1 DUF1852 domain-containing protein -
EGT68_RS07790 (EGT68_007790) 1607068..1608096 + 1029 WP_004911103.1 methionine synthase -
EGT68_RS07795 (EGT68_007795) 1608283..1608777 + 495 WP_004911101.1 flavin reductase -
EGT68_RS07800 (EGT68_007800) 1608819..1609616 + 798 WP_004911097.1 sulfite exporter TauE/SafE family protein -
EGT68_RS07805 (EGT68_007805) 1609676..1610374 - 699 WP_125272797.1 DUF1826 domain-containing protein -
EGT68_RS07810 (EGT68_007810) 1610652..1611983 + 1332 WP_087540912.1 HipA domain-containing protein Toxin
EGT68_RS07815 (EGT68_007815) 1611980..1612288 + 309 WP_087540911.1 helix-turn-helix domain-containing protein Antitoxin
EGT68_RS07820 (EGT68_007820) 1612366..1612500 - 135 Protein_1526 VF530 family DNA-binding protein -
EGT68_RS07825 (EGT68_007825) 1612902..1613867 + 966 WP_228272826.1 AAA family ATPase -
EGT68_RS07830 (EGT68_007830) 1613879..1615017 + 1139 WP_100223103.1 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(167-363)

Antitoxin

Cro/C1-type helix-turn-helix domain

(29-82)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 50699.39 Da        Isoelectric Point: 4.8438

>T208952 WP_087540912.1 NZ_CP078042:1610652-1611983 [Acinetobacter junii]
MKKLTIQALLDQSWFDIAELTLLEPKLGSASASELAYELEYAIHNLDKRDEHACGLSLPVQLLIKHESSSWFGFLDDIVP
SGAARRYWVNFLGLQRLTYAEQDSILLEKGGIAPVGNLRIKEALPPINPESTLHLRYFSQSDVADRNVDFLEYAQQMGAI
SGGATGAGGEAPKLLIRATKDQNIWIDTYQQNFDQPDQHYLVKFPRNNRSEIDCNILRAEYYYYQELKELGFNTIETTEM
KLIEGEKYPSLWLPRFDVEWHNQKWHRYGLESVYSVLNKASGSHLNHFEVIENLCNLLISIDSEFDSEQFVCEWLQRDLL
NIIFGNSDNHGRNTSFLKQSGKISLAPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYQWEQITQKLAHLCDPNLSLTTLK
SLASHLVGLKQRLIDKGVPKQIMEIPALSFDYVEAKLERWELL

Download         Length: 1332 bp

>T208952 NZ_CP103762:2148576-2148679 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11722.67 Da        Isoelectric Point: 9.9970

>AT208952 WP_087540911.1 NZ_CP078042:1611980-1612288 [Acinetobacter junii]
MNTKNQTQDRQQVLIDLYMQYLLNEITLGQLLAYLRKNILSMSQEQYANLVGVSRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVRKIIKPSE

Download         Length: 309 bp

>AT208952 NZ_CP103762:c2148717-2148446 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGCCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References