Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type VII Classification (family/domain) HepT-MntA/HepT(toxin)
Location 3234222..3235038 Replicon chromosome
Accession NZ_CP078038
Organism Shewanella putrefaciens strain SA70

Toxin (Protein)


Gene name hepT Uniprot ID A0A252EQR5
Locus tag B7D78_RS14150 Protein ID WP_069455295.1
Coordinates 3234637..3235038 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name mntA Uniprot ID A0A501X4H4
Locus tag B7D78_RS14145 Protein ID WP_069455294.1
Coordinates 3234222..3234644 (+) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7D78_RS14125 (KVP08_014125) 3229636..3230526 - 891 WP_086904476.1 glucose-1-phosphate thymidylyltransferase RfbA -
B7D78_RS14130 (KVP08_014130) 3230850..3232211 - 1362 WP_086904477.1 GAF domain-containing sensor histidine kinase -
B7D78_RS14135 (KVP08_014135) 3232629..3233072 + 444 WP_086904478.1 copper resistance protein NlpE -
B7D78_RS14140 (KVP08_014140) 3233348..3234115 + 768 WP_086904479.1 HutD family protein -
B7D78_RS14145 (KVP08_014145) 3234222..3234644 + 423 WP_069455294.1 type II toxin-antitoxin system antitoxin Antitoxin
B7D78_RS14150 (KVP08_014150) 3234637..3235038 + 402 WP_069455295.1 type II toxin-antitoxin system toxin Toxin
B7D78_RS14155 (KVP08_014155) 3235232..3236263 - 1032 WP_218558454.1 dTDP-glucose 4,6-dehydratase -
B7D78_RS14160 (KVP08_014160) 3236821..3238382 + 1562 Protein_2745 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease HepT-like

(12-129)

Antitoxin

Polymerase beta, nucleotidyltransferase

(7-97)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15296.57 Da        Isoelectric Point: 6.3185

>T208948 WP_069455295.1 NZ_CP078038:3234637-3235038 [Shewanella putrefaciens]
MNDIIINKIATIKRCIKRIQQVYGDGSQFKQDFTLQDSVILNLQRCCEACIDIANHINRQQQLGIPQSSRDSFTLLAQNN
LITQPLADNLKKMVGLRNIAVHDYQELNLDIVVHVVQHHLEDFEQFIDVIKAE

Download         Length: 402 bp

>T208948 NZ_CP103762:1026661-1026996 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAGCTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 15795.88 Da        Isoelectric Point: 5.1520

>AT208948 WP_069455294.1 NZ_CP078038:3234222-3234644 [Shewanella putrefaciens]
MQQLNEKKIIKLLRDNIPKLQLIYLFGSYSQGTQHRNSDIDIAVLAADTLDNIARWELAQKLASALDSDVDLVDLRSAST
VLCQQVVTQGKQLWGTQQDDELFAVKTISMYQHLQAERQAIIDDVMANTAAKDHRGSHFE

Download         Length: 423 bp

>AT208948 NZ_CP103762:1026413-1026661 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A252EQR5

Antitoxin

Source ID Structure
AlphaFold DB A0A501X4H4

References