Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4868808..4869324 Replicon chromosome
Accession NZ_CP078033
Organism Klebsiella pneumoniae strain KP_160

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag EGK18_RS23575 Protein ID WP_004178374.1
Coordinates 4868808..4869092 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag EGK18_RS23580 Protein ID WP_002886901.1
Coordinates 4869082..4869324 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGK18_RS23550 (4864292) 4864292..4864555 - 264 WP_228985702.1 PTS sugar transporter subunit IIB -
EGK18_RS23555 (4864685) 4864685..4864858 + 174 WP_032408826.1 hypothetical protein -
EGK18_RS23560 (4864861) 4864861..4865604 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
EGK18_RS23565 (4865961) 4865961..4868099 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
EGK18_RS23570 (4868340) 4868340..4868804 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
EGK18_RS23575 (4868808) 4868808..4869092 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EGK18_RS23580 (4869082) 4869082..4869324 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EGK18_RS23585 (4869402) 4869402..4871312 - 1911 WP_004178373.1 PRD domain-containing protein -
EGK18_RS23590 (4871335) 4871335..4872489 - 1155 WP_004178372.1 lactonase family protein -
EGK18_RS23595 (4872556) 4872556..4873296 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T208936 WP_004178374.1 NZ_CP078033:c4869092-4868808 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T208936 NZ_CP103758:3681544-3681822 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT208936 WP_002886901.1 NZ_CP078033:c4869324-4869082 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT208936 NZ_CP103758:3681281-3681541 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References