Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2788862..2790450 Replicon chromosome
Accession NZ_CP078033
Organism Klebsiella pneumoniae strain KP_160

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag EGK18_RS13690 Protein ID WP_004179815.1
Coordinates 2788862..2790184 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag EGK18_RS13695 Protein ID WP_004176198.1
Coordinates 2790184..2790450 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGK18_RS13675 (2783918) 2783918..2786419 + 2502 WP_004179823.1 fimbria/pilus outer membrane usher protein -
EGK18_RS13680 (2786407) 2786407..2787411 + 1005 WP_004179822.1 fimbrial protein -
EGK18_RS13685 (2787553) 2787553..2788845 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
EGK18_RS13690 (2788862) 2788862..2790184 - 1323 WP_004179815.1 type II toxin-antitoxin system HipA family toxin Toxin
EGK18_RS13695 (2790184) 2790184..2790450 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
EGK18_RS13700 (2790716) 2790716..2791042 - 327 WP_002904788.1 hydroxyisourate hydrolase -
EGK18_RS13705 (2791039) 2791039..2791539 - 501 WP_004179811.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
EGK18_RS13710 (2791517) 2791517..2792896 - 1380 WP_004179808.1 nucleobase:cation symporter-2 family protein -
EGK18_RS13715 (2793242) 2793242..2794396 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
EGK18_RS13720 (2794377) 2794377..2795300 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49152.42 Da        Isoelectric Point: 7.2850

>T208932 WP_004179815.1 NZ_CP078033:c2790184-2788862 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T208932 NZ_CP103758:2615411-2615518 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT208932 WP_004176198.1 NZ_CP078033:c2790450-2790184 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT208932 NZ_CP103758:c2615364-2615298 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References