Detailed information of TA system TA208923

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 817322..817979
• Replicon: chromosome
• Accession: NZ_CP078033
• Organism: Klebsiella pneumoniae strain KP_160

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: EGK18_RS04010
• Protein ID: WP_004181233.1
• Coordinates: 817569..817979 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: W8UQ37
• Locus tag: EGK18_RS04005
• Protein ID: WP_002916312.1
• Coordinates: 817322..817588 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGK18_RS03980 (812478)	812478..813911	-	1434	WP_004181234.1	6-phospho-beta-glucosidase	-
EGK18_RS03985 (814030)	814030..814758	-	729	WP_002916321.1	MurR/RpiR family transcriptional regulator	-
EGK18_RS03990 (814808)	814808..815119	+	312	WP_004144734.1	N(4)-acetylcytidine aminohydrolase	-
EGK18_RS03995 (815283)	815283..815942	+	660	WP_002916317.1	hemolysin III family protein	-
EGK18_RS04000 (816093)	816093..817076	-	984	WP_002916313.1	tRNA-modifying protein YgfZ	-
EGK18_RS04005 (817322)	817322..817588	+	267	WP_002916312.1	FAD assembly factor SdhE	Antitoxin
EGK18_RS04010 (817569)	817569..817979	+	411	WP_004181233.1	protein YgfX	Toxin
EGK18_RS04015 (817986)	817986..818507	-	522	WP_004144730.1	flavodoxin FldB	-
EGK18_RS04020 (818608)	818608..819504	+	897	WP_004144729.1	site-specific tyrosine recombinase XerD	-
EGK18_RS04025 (819527)	819527..820240	+	714	WP_002916301.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
EGK18_RS04030 (820246)	820246..821979	+	1734	WP_004149758.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16121.92 Da
• Isoelectric Point: 11.1565

>T208923 WP_004181233.1 NZ_CP078033:817569-817979 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAEEWRDLRRLVLQKPAQE

Nucleotide

• Length: 411 bp

>T208923 NZ_CP103758:623058-623372 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10480.98 Da
• Isoelectric Point: 5.1116

>AT208923 WP_002916312.1 NZ_CP078033:817322-817588 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT208923 NZ_CP103758:623369-623785 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GY41