Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | PumA-relB/upstrm_HI1419-dnstrm_HI1420 |
Location | 12970..13554 | Replicon | plasmid pAV_175-4 |
Accession | NZ_CP078030 | ||
Organism | Acinetobacter variabilis strain AV_175 |
Toxin (Protein)
Gene name | PumA | Uniprot ID | N8Q7V3 |
Locus tag | EGK58_RS16680 | Protein ID | WP_000286964.1 |
Coordinates | 13252..13554 (-) | Length | 101 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | - |
Locus tag | EGK58_RS16675 | Protein ID | WP_000985609.1 |
Coordinates | 12970..13251 (-) | Length | 94 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
EGK58_RS16640 (EGK58_016640) | 9228..9500 | - | 273 | WP_000369781.1 | NadS family protein | - |
EGK58_RS16645 (EGK58_016645) | 9493..9813 | - | 321 | WP_000897307.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
EGK58_RS16650 (EGK58_016650) | 9953..10177 | + | 225 | WP_125279881.1 | SMI1/KNR4 family protein | - |
EGK58_RS16655 (EGK58_016655) | 10199..10582 | + | 384 | WP_001055589.1 | transposase | - |
EGK58_RS16660 (EGK58_016660) | 10579..10914 | + | 336 | WP_219014810.1 | IS66 family insertion sequence element accessory protein TnpB | - |
EGK58_RS16665 (EGK58_016665) | 10989..12593 | + | 1605 | WP_219014809.1 | IS66 family transposase | - |
EGK58_RS16670 (EGK58_016670) | 12651..12890 | + | 240 | WP_267460446.1 | SMI1/KNR4 family protein | - |
EGK58_RS16675 (EGK58_016675) | 12970..13251 | - | 282 | WP_000985609.1 | putative addiction module antidote protein | Antitoxin |
EGK58_RS16680 (EGK58_016680) | 13252..13554 | - | 303 | WP_000286964.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
EGK58_RS16685 (EGK58_016685) | 13703..14233 | + | 531 | WP_000172759.1 | hypothetical protein | - |
EGK58_RS16690 (EGK58_016690) | 14322..14636 | - | 315 | WP_004728120.1 | BrnA antitoxin family protein | - |
EGK58_RS16695 (EGK58_016695) | 14623..14910 | - | 288 | WP_000438825.1 | BrnT family toxin | - |
EGK58_RS16700 (EGK58_016700) | 15164..16117 | - | 954 | WP_125279689.1 | hypothetical protein | - |
EGK58_RS16705 (EGK58_016705) | 16370..17551 | + | 1182 | WP_077448184.1 | cation diffusion facilitator family transporter | - |
EGK58_RS16710 (EGK58_016710) | 17833..18399 | - | 567 | WP_125279690.1 | plasmid replication DNA-binding protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | tet(39) / mph(E) / msr(E) | - | 1..19843 | 19843 | |
- | inside | IScluster/Tn | tet(39) / mph(E) / msr(E) | - | 4172..12593 | 8421 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11573.07 Da Isoelectric Point: 4.6838
>T208920 WP_000286964.1 NZ_CP078030:c13554-13252 [Acinetobacter variabilis]
MYSIYTTEVFDDWFTKLKDQQAKRRIQVRIDRVEDGNFGDTEPVGEGVSELRFFFGPGYRIYYCKQGQRVVILLAGGDKS
TQSKDIKLALQLAQDLEEEL
MYSIYTTEVFDDWFTKLKDQQAKRRIQVRIDRVEDGNFGDTEPVGEGVSELRFFFGPGYRIYYCKQGQRVVILLAGGDKS
TQSKDIKLALQLAQDLEEEL
Download Length: 303 bp
>T208920 NZ_CP103758:184582-184689 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAG
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAG
Antitoxin
Download Length: 94 a.a. Molecular weight: 10109.67 Da Isoelectric Point: 8.0018
>AT208920 WP_000985609.1 NZ_CP078030:c13251-12970 [Acinetobacter variabilis]
MAIKLRKWDSAEHLKTEDDMQAYLQACIEESNGDAAFIAKALGNIAKAKGMAQLSRDTGLGRESLYKALSGDVNPSFDTV
IKVVKALNLRLAI
MAIKLRKWDSAEHLKTEDDMQAYLQACIEESNGDAAFIAKALGNIAKAKGMAQLSRDTGLGRESLYKALSGDVNPSFDTV
IKVVKALNLRLAI
Download Length: 282 bp
>AT208920 NZ_CP103758:c184534-184468 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|